Posted by admin on Aug 31, 2024 in |
Lepromatous leprosy is a chronic infectious disease caused by Mycobacterium leprae, characterized by the extensive involvement of skin and peripheral nerves. While it commonly affects the cooler regions of the body, such as the extremities, ears, and face, involvement of the muzzle area is exceedingly rare. We present a unique case of lepromatous leprosy in a 42-year-old male, where the initial manifestation of the disease primarily occurred in the muzzle area. This case report highlights the atypical clinical presentation of lepromatous leprosy, which typically spares the central face and mucous membranes. The patient exhibited disfiguring nodules, erythema, and sensory loss in the muzzle area, leading to a delayed diagnosis due to the unusual site of involvement. A comprehensive clinical evaluation, histopathological examination, and microbiological confirmation were pivotal in establishing the diagnosis. The rarity of muzzle area involvement in lepromatous leprosy underscores the importance of maintaining a high index of suspicion for atypical presentations, especially in regions where leprosy is endemic. Early detection and multidrug therapy remain crucial in preventing...
Read More
Posted by admin on Aug 31, 2024 in |
Background: A vaccine supply chain is the complex system of steps, processes, equipment, vehicles and locations involved in getting vaccines from their origin to their destination. Failure to understand and properly address this system can greatly reduce the impact of any vaccine. It is also necessary that the condition of cold chain equipment i.e., deep freezer and ice- lined refrigerator (ILR) is maintained appropriately and emergency plan in case of cold chain failure is followed adequately. Material and Methods: An observational cross-sectional study was carried out to assess the functioning of cold chain points after implementation of eVIN (electronic vaccine intelligence network) from January 2022 to August 2022. 34 out of 40 cold chain points in district Nainital who responded were visited and assessed. Collected data were compiled in MS Excel and analyzed using percentages. Result: The findings of this assessment suggest positive changes in the areas of vaccine utilization, stock management and distribution and documentation. The findings revealed that the exposure to sub‑zero temperature and >8°C occurred at...
Read More
Posted by admin on Aug 31, 2024 in |
The present study was aimed to analyze the prescription pattern of the diabetic patients with clinical profile with specific objective to determine the current trend of anti-diabetic drugs. According to the report obtained from the study, the male patients are more prone to diabetes mellitus than females. Type 2 diabetes mellitus is widely observed where study was carried out. There is the need for change in the lifestyle of diabetic patients as per observed social habits. The diabetes patients were in the age group of 51-60 years. Hypertension affected more than 29.73% of diabetic patients according to the present study. The prescription pattern of antihypertensive drugs and cardiovascular drugs are based upon the guideline’s combination drugs by majority of the diabetic patients. The drugs pattern of oral hypoglycemic is also based upon the National list of essential medicines (NLEM 2015) and Dual therapy with metformin + Glimepiride is widely prescribed among these subjects. Proper dose calculations of insulin have been carried out based upon the BMI levels and various...
Read More
Posted by admin on Aug 31, 2024 in |
Health care associated infections (HAIs) are frequently caused by Klebsiella pneumoniae (K. pneumoniae) which has a high level of antibiotic resistance pattern and the ability to form biofilms. In this research work, 105 K. pneumoniae was isolated from both inpatients and outpatients between January 2021 and January 2022 at the tertiary care hospital viz, Mahatma Gandhi Medical College and Research Institute (MGMCRI), India. The K. pneumoniae isolates were further analysed using morphological analysis of the colonies, microscopic examination, and biochemical testing. The Kirby Bauer disk diffusion method and adhesion quantitative assays were utilized for testing antibiotic susceptibility and biofilm- producing capacity. K. pneumoniae isolates were mostly derived from the urine specimens (42.9%) and pus (19.0%). Most of the K. pneumoniae were resistant to a wide range of antibiotics and is also well known to the ability to produce biofilm. This study shows that the biofilm producing K. pneumoniae has been a good resistant to Ceftriaxone/Cefotaxime (80.9%), Amikacin (78.7%), Piperacillin+ Tazobactam (79.8%), and Meropenem (79.8%). On the contrary among non-...
Read More
Posted by admin on Aug 31, 2024 in |
Nowadays increase in UV induced skin ailments and adverse effects of synthetic UV filters, prompted researchers to focus on natural compounds capable of absorbing UV rays. Garcinia indica is a rich source of benzophenones, which are present in all plant parts. As per earlier reports, ethyl acetate root extract of it exhibits the highest SPF (7) than other plant parts. The present study aims to characterise anti-UV benzophenones and screening of in-vitro roots for it. Natural root extract subjected to silica gel column chromatography. The column fractions were analysed using a spectrophotometer and thin-layer chromatography. Initial fractions eluted in hexane to hexane: ethyl acetate 90:10 or 80:20 displayed a fluorescent blue band on the TLC plate and showed absorbance in the UV B region. As the concentration of ethyl acetate increased (Hexane: Ethyl acetate 70: 30) the eluted fractions exhibited an additional fluorescent green band. These fractions had a broad-spectrum UV absorption activity contributing to SPF and Boot star ratings. HPTLC-MS analysis of these two bands characterized garcinol (m/z...
Read More
