Posted by admin on Aug 31, 2021 in |
Zingerone is an active phenolic acid and the least pungent component of Zingiber officinale. It is known to exhibit different pharmacological properties which include anti-inflammatory, antioxidant, anticancer and antimicrobial activities. But, so far there has been no information available on the role of zingerone in experimental breast carcinogenesis. The objective of this experiment is to untwine the anticancer qualities of zingerone against dimethylbenz (a) anthracene (DMBA)-incited mammary carcinogenesis. To achieve this goal, female Sprague-Dawley rats were arbitrarily classified into six groups. Group 1 was notified as the control, groups 2-5 were given a single dose of DMBA (25 mg/kg b.wt, subcutaneously) in the 4th week. Along with DMBA, groups 3 (initium), 4 (post-initium) and 5 (entire period) rats received zingerone (20mg/kg b.wt. p.o) every day in different time periods during the experimental period of 16 weeks. Group 6 rats received 20 mg/kg b.wt. of zingerone alone. Cancer-bearing animal mammary tissue when evaluated by western blot showed increased immune expression patterns of ER, PR, HER2/ neu, cyclin D1 and also...
Read More
Posted by admin on Aug 31, 2021 in |
One of the major barriers in the development of oral dosage form is poor solubility. Poor water solubility obstructs drug bioavailability and decreases its pharmaceutical development. Many drugs are in the pipeline to enhance solubility to formulate dosage form to be taken by the most preferred route of administration that is the oral route. Etodolac is nonsteroidal anti-inflammatory drug having a wide spectrum of activities but belongs to BCS class II. The attempt has been made in this work to improve solubility by forming ternary inclusion complexes of Etodolac with PVP K30 and β-Cyclodextrins. The ternary inclusion complexes were prepared by the physical mixing method and kneading method. The prepared complexes were analyzed by different analytical techniques comprising differential scanning calorimetry, infrared spectroscopy and solubility study. Special emphasis was given on the solubility evaluation of drugs and complexes. Based on observations and results, one can easily conclude about the usefulness of the complexation technique for the enhancement of...
Read More
Posted by admin on Aug 31, 2021 in |
Posted by admin on Aug 31, 2021 in |
The non-invasive technique in which a variety of nanoparticles are used to deliver the chemotherapy drug to the location of metastatic cancer has fewer side effects, high bio-availability, and high bio-stability of a drug. The anti-proliferative activity of EGCG is very efficient against a variety of cancer, but the problem is that it can’t withstand the environment of an intestine. One of the nano-system is Spanlastic (type of niosome system) which can carry both lipophilic and hydrophilic drugs. Spanlastic is capable of holding a large amount of drugs; also, the penetration potential of spanlastic is very efficient due to the addition of cholesterol and ethanol in it. Non-ionic surfactant made up of Span-60 (mono-stearate), and the edge activator made of Tween-80 increases the flexibility and deformability of the system. Ethanol injection will be used to prepare the EGCG loaded spanlastic system. After preparing, the Z-average diameter, polydispersity index, and spanlastic will be determined by dynamic light scattering (DLS) and, with the help TEM imaging, will check the shape and...
Read More
Posted by admin on Aug 31, 2021 in |
Quinoline or 1-aza-naphthalene or benzo [b] pyridine is a weak tertiary base. In the study, the synthesis of compounds and their antimicrobial activity which is not done earlier and is quite significant. An attempt has been made for the synthesis of N’-(substituted benzylidene)-2-(7-bromo-2-phenylquinazolin-4-yloxy) acetohydrazide (5-15). The titled compounds were prepared by the reaction of bromoanthranilic acid with benzoyl chloride which gave oxazine-4-one derivative (1), which on reaction with formamide gave quinazolin-4(3H)-one derivative (2). The esterification product of quinazolin-4(3H)-one derivative, when reacted with hydrazine-hydrate gave (7-bromo-2-phenylquinazolin-4yloxy) acetohydrazide (4). The sub stituted benzaldehyde on reaction with 7-Bromo-2-phenylquinazoline-4yloxyacetohydrazide (4) yielded N’-(sub stituted benzylidene)-2-(7-bromo-2-phenyl quinazolin-4-yloxy) acetohydrazide (5-15). Primarily the structures of all synthesized compounds were confirmed from Melting point and TLC methods and then spectral analysis IR, 1H NMR and mass spectra. All synthesized derivative compounds were evaluated for their in vitro antimicrobial activities using the disc diffusion technique. It was found that all the synthesized compounds exhibit antimicrobial activity and that compounds 7, 11, 13 and 14 have a broad spectrum of...
Read More
