Posted by admin on Aug 31, 2020 in |
Asthma is a chronic disease; there is a need for a drug delivery system that maintains adequate therapeutic concentrations for a longer duration of action to improve better clinical efficacy. Salbutamol sulphate (SS) is a widely prescribed drug to treat asthma though it has short plasma half-life and undergoes extensive first-pass metabolism. Thus, it necessitates frequent administration by oral route to maintain adequate plasma concentrations. Hence an attempt was made to formulate and evaluate transdermal ethosomal gel formulations of SS to improve therapeutic efficiency and to reduce the dosage regimen. Ethosomal suspensions of drugs were prepared using phosphatidylcholine, alcohol, propylene glycol, and cholesterol. Then, suspensions were used to develop gels by incorporating them into carbopol. Formulations were evaluated for vesicular size, size distribution, scanning electron microscopy, drug content estimation, drug entrapment efficiency, in-vitro diffusion studies, Z-Average, polydispersity index (PDI), and zeta potential measurement. Analytical studies confirmed the absence of drug and polymer interaction. Drug content of ethosomal suspensions and gel formulations was found uniform, and microscopic images displayed that...
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Posted by admin on Aug 31, 2020 in |
The current studies details QbD enable the development of a simple, rapid, and cost-effective reverse phase high performance liquid chromatographic method for estimation of Acotiamide hydrochloride hydrate. The simple analytical RP-HPLC method was developed using Box-Behnken Design (BBD). In the present work, three independent factors were used, such as org phase (A), aqueous phase (B), and flow rate (C). Totally 17 experimental runs were suggested by the software for analyzing the interaction, and the tailing factor (R1), retention time (R2), and area (R3) were considered as response factors (dependent factors). The developed experimental design was statistically analyzed using ANOVA, counterplots, and surface response curves. The optimal chromatographic separation was achieved using Hyperchrom ODS C18 (4.6×250 mm, 5µ) analytical column with a mobile phase containing potassium dihydrogen phosphate buffer (pH 6.8): Acetonitrile (60:40 v/v) with the flow rate of 1 ml/min using PDA detector. The retention time of the drug was found to be 5.2646 min at a detection wavelength of 282 nm. The method was found to be linear in...
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Posted by admin on Aug 31, 2020 in |
Mangrove plants are used in medicines, and extracts from mangrove species have proven inhibitory activity against human, animal, and plant pathogens. Endophytic fungi are an important component, are universal, and occur within all know plants, including a broad range of hosts in various ecosystems, and therefore play an important role in the natural environment. Numerous species of mangrove produce bioactive compounds that can control microbial growth. Mangrove extracts can also be the likely sources of mosquito larvicides, antifungal, antiviral, anti-cancer, and anti-diabetic complexes. Mangrove endophytic fungi with promising antioxidant activities that may be useful to humans as novel physiological agents. The present review deals with the endophytic fungi from mangrove...
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Posted by admin on Aug 31, 2020 in |
The serotonin syndrome is a life-threatening adverse drug reaction caused by a significant increase in the concentration of 5-hydroxytryptamine (serotonin) in the central nervous system. The aim of this study was to establish the effects of olanzapine, an antipsychotic drug, on the hyperthermic response in rat experimental serotonin syndrome. In this study, we used an animal model of the serotonin syndrome induced by co-administration of fluoxetine and tranylcypromine. The body temperature of the animals was measured with thermistor probes (TX-8) inserted rectally and monitored on multichannel recorder. Pre-treatment with olanzapine inhibits hyper-thermic reaction in an experimental model of the serotonin syndrome and converts a hyperthermic response to serotonergic combination (fluoxetine and tranylcypromine) into a hypothermic response. Our results suggest prevention of the hyperthermia in a serotonin syndrome model with the use of olanzapine and support the hypothesis that the hyperthermic reaction in serotonin syndrome is mediated by activation of central 5-HT2...
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Posted by admin on Aug 31, 2020 in |
A series of pyrazole derivatives designing for potential EGFR kinase inhibitors have been discovered. Some of them exhibited significant EGFR inhibitory activity. Compound 3-(4-Amino-phenyl)-5-(3-nitro-phenyl)-4, 5-dihydro-pyrazole-1-carbothioic acid amide (AP-2) displayed the most potent EGFR inhibitory activity. The QSAR analysis of a set of these compounds tested for growth inhibitory activity against EGFR were performed by using the computer-assisted multiple regression procedure. The activity contributions for substituent effects of these compounds were determined from the correlation equation for predictions of the lead optimization. QSAR analysis of these compounds was performed by multiple regression analysis in order to predict the lead optimization for anticancer activity against...
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