Posted by admin on Aug 31, 2024 in |
Cigarette smoking and excessive chronic alcohol consumption are accepted risk factors for the causation of various diseases and disorders. Globally 2.5 billion alcoholics and 2.0 billion smokers exist (WHO, 2018). The comorbidity of alcohol and cigarette smoking is highly prevalent. This study is designed to investigate the influence of green tea an effective therapeutic agent to treat the damage caused by the co-use of cigarette smoking and alcohol in humans. Green tea, a water infusion prepared from the dried leaves of Camellia sinensis, is one of the most popular beverages in the world. The major tea catechins are Epigallocatechin-3-gallate (EGCG), Epicatechin (EC), Epicatechin gallate (ECG), Epigallocatechin (EGC). This study had a participation of 150 healthy adult male volunteers between 35 to 65 years of age and weighing between 70 to 85 kg. In this study, EGCG catechin metabolites were detected in the plasma and urine of human volunteers after supplementation of green tea. The served green tea showed the concentrations of various catechins especially EGCG (81.24%), ECG (1.13%), EGC...
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Posted by admin on Aug 31, 2024 in |
Hyperlipidemia is a systemic disease, which is characterized by elevated lipid levels in blood including total cholesterol (TC), total glyceride (TG), low density lipoprotein cholesterol (LDL-c) and so on. It is one of the major risk factors leading to fatty liver, cardiovascular diseases and atherosclerosis and become the first killer of human health. The present study involves synthesis of some novel heterocycles of benzoxazole derivatives containing Oxadiazole and amino triazole and its evaluation of in-vivo and in-silico molecular docking for determining antihyperlipidemic activity. The chemical structures of newly synthesized compounds were evaluated by spectrum of IR, 1HNMR, and LC-MS. The molecular docking studies for the synthesized compounds with PCSK9 showed energy levels ranging from -8 to -10kcal/mol. The compound VD1which shows least binding energy taken for in-vivo antihyperlipidemic activity study. The antihyperlipidemic activity was evaluated by high fat diet induced hyperlipidaemia model and the compound VD1 showed significant reduction in serum lipid parameters as that of standard drug...
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Posted by admin on Aug 31, 2024 in |
Dineśavallīor Vēṁpātais a very popular Ᾱyurvēda herb used in South India for skin related ailments. In Kerala it is used in different formulations either as single drug or in combinations. There are no direct references to dineśavallī or Vēṁpāta in any bŗhatrayī or laghutrayī. From the previous studies it is confirmed that dineśavalli of south India is equated with ‘Ratanjot’– a herbal dye of North India and from the literature review, roots of Arnebia and Alkanna which is sold as ‘Ratanjot’. Dineshavalli (Vēṁpāta) is assumed to be sourced from Ventilago madraspatana Gaertn. belonging to Rhamnaceae family. But some allied species such as Ventilago bombaiensis Dalzell. and Ventilago denticulata Willd. are also termed as Vēṁpāta locally. Present study reviews the major classical texts of Ayurveda and peer reviewed articles to reveal the botanical identity, chemical constituents, pharmacological properties and its therapeutic efficacy of Dineśavallī or Vēṁpāta for the better...
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Posted by admin on Aug 31, 2024 in |
Metabolic syndrome is the most widely and prevailing health concern globally. It is a cluster of biochemical and physiological abnormalities that involve obesity, insulin resistance, dyslipidemia, and hypertension. Several studies have reported that the prevalence of the overall metabolic syndrome rate in adults is about 25% (approx. 31% in women and 18.5% in men) in India. Whereas the global prevalence is about 20-25% in 2020. The direct relationship between diet and health leads to various scientific studies to find the significant relation and their specific beneficial functions. Certain foods are thought to have physiological effects in the management of metabolic syndrome by assisting the body’s hemostasis mechanism. The present paper reviews different features of nutraceuticals and functional foods and their influence on the management of metabolic syndrome. Also, it overviews numerous functional ingredients in different food sources and their possible health...
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Posted by admin on Aug 31, 2024 in |
Osteoarthritis in the hip creates a major cause of pain and functional limitation. Acupuncture is an effective treatment for reducing inflammation and protecting muscles and produce pain control associated with disorder. Acupuncture is a proven, comprehensive method that helps to restore normal body function. The aim of this study is to find out the effect of acupuncture for relieving chronic hip pain. Here we report a 45-year-old female presenting with swelling, redness and pain on the right hip and with left hip congenital dislocation and eventually diagnosed as right hip osteoarthritis. X-ray showed superior congenital dislocation of left hip. The patient was treated with the selected acupoints ST44, ST36, UB 32, UB 35, UB 40, GB 32, LI4, LI11, DU20, P6, UB60, UB11, and GB34 for half an hour in alternate day for one week and then 15 days once followed for 6 months. VAS was used to measure pain. After treatment, the patient showed improvement in pain and functional ability. The patient is under regular check...
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