Posted by admin on Aug 31, 2025 in |
Tuberculosis (TB) continues to rank among the world’s most serious health problems despite the remarkable biomedical achievements. The objective of the study is to describe and characterize the adverse drug reactions associated with Anti Tubercular Therapy (ATT) in a tertiary care hospital. This was a cross sectional study done in the Department of Thoracic medicine, Government Medical College Krishnagiri between May 2023 and July 2023(3 months). Around 240 patients taking anti-tubercular drugs were screened and 98 patients (40.8%) among them were found to have adverse reactions to the therapy. Incidence of ADR was highest (8.3%) among (21-30) and (51-60) age groups. Among the type of detected adverse drug reactions induced by anti-TB drugs, gastritis (8.3%) was the most common, followed by rash (5%), hepatitis (4.2%) with hard of hearing (0.8%) and vision abnormality (0.8%) being the least common. Causality assessment revealed around 64 ADRs (26.7%) had possible relation to the drug usage. severity assessment of ADRs induced by ATT revealed mild in 52 patients (21.7%), moderate in 44 patients...
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Posted by admin on Aug 31, 2025 in |
Invasomes, within the scope of transdermal medication delivery and cosmetic formulations, nowadays have emerged as impressive technology and are described in comprehensive detail in this review paper. Essentially, invasomes are built from a unique substance, techniques, and processes that can enable active compounds to penetrate easier into the skin than standard liposomes, with the help of phospholipids, ethanol, and terpenes while remaining within the skin boundaries and decreasing systemic absorption. This paper discusses the advantages of invasomes over the conventional delivery systems, including enhanced bioavailability and targeted delivery of therapeutic agents. Other aspects discussed include advancements in nanotechnology and process automation to reduce the production cost and enhance the scalability without any compromise on quality. Review of applications of invasomes in dermo-cosmetic products focuses on their role in treating skin dysfunctions. In summary, it is underscored in this paper that invasomes can revolutionize skincare formulations and hence help overcome multiple dermatological...
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Posted by admin on Aug 31, 2025 in |
The current research is to develop an easy and eco-friendly method for synthesizing Flower silver nanoparticles [FAgNPs] and Stem silver nanoparticles [SagNPs] using an aqueous extract of flower and stem Leonotis nepetifolia, (L.) R. Br. (family: Lamiaceae), and to evaluate their antibacterial properties. The obtained sample of synthesized FAgNPs and SAgNPs were characterized by UV–vis spectrophotometer, Zeta potential, X-ray Diffraction [XRD], Field Electron- scanning electron microscope [FE-SEM], and Fourier transform infrared spectroscopy [FT-IR] analysis. The formation of FAgNPs and SAgNPs was confirmed by the observation of band between 300 nm to 700 nm UV–vis spectrum. The crystalline structure of FAgNPs and SAgNPs with a face- centered cubic (FCC) was confirmed by XRD. The responsible phytochemicals for the reducing and capping agents of FAgNPs and SAgNPs were observed with FT-IR spectra analysis. The FE-SEM monograph revealed the spherical shape and size of FAgNPs and SAgNPs. Hence synthesized AgNPs were found to be in nano size and stable. Furthermore, the biosynthesized FAgNPs and SAgNPs indicated adequate antibacterial activity against clinical pathogen,...
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Posted by admin on Aug 31, 2025 in |
It is leukaemia, where immature white blood cells keep growing at a very fast pace and disrupt normal blood production. While there are many advances in treatment, genetics diversity, drug resistant and technological limits remain. Likewise, such AI combined with multi dimension approaches (genetics, transcriptomics, proteomics, metabolism, and epigenetics) has altered leukaemia research. Divining the diagnosis, risk assessment and precise plan for effective treatment from vast amounts of data allowed by AI is possible. In addition, it shortens the time of diagnosis, predicts responses to therapy, and explains how it fails. By integrating AI into mitigation of CML, tyrosine kinase inhibitor is first identified and targeted therapy is guided by other key biomarkers. Same is the case for AML which is mitigated by CK inhibitors and FLT3 inhibitors. Interruption and identification of various pathways by metabolomics and proteomics provide new therapeutic targets. More and more clinical studies show that AI assisted multi-omics strategies add value in making personalized care, reducing relapse, and increasing survival. Since challenges such as data...
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Posted by admin on Aug 31, 2025 in |
Cancer remains a major cause of mortality worldwide, with chemotherapy serving as a cornerstone of cancer treatment. While effective in targeting malignant cells, chemotherapy is associated with debilitating side effects, including cachexia a complex, multifactorial syndrome characterized by unintentional weight loss, muscle wasting, fatigue, and reduced physical function. This condition arises from cancer progression and chemotherapy-induced toxicity, compounded by systemic inflammation, oxidative stress, and mitochondrial dysfunction. Chemotherapy agents trigger the release of pro-inflammatory cytokines, promote the generation of reactive oxygen species, and activate the ubiquitin-proteasome system, all of which contribute to skeletal muscle atrophy. The resulting impairment in physical function, diminished treatment tolerance, and worsened prognosis significantly impact patient outcomes. Unlike general cancer-associated muscle wasting, chemotherapy-induced cachexia involves unique mechanisms, including the activation of nuclear factor kappa beta and mitogen-activated protein kinase pathways by agents such as Cisplatin. Cachexia is further aggravated by side effects such as reduced appetite, nausea, and fatigue, leading to myosteatosis and deterioration in muscle mass and function. Current therapeutic approaches include pharmacological agents such...
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