Posted by admin on Aug 31, 2019 in |
The Increase in industrialization has raised the levels of heavy metal pollution in the country. Heavy metals are entering through the water supply, which is ultimately reaching into streams, lakes, rivers, and groundwater. So, ultimately, these heavy metals are causing environmental pollution, which is becoming a threat to humans as well as animals as the heavy metal pollution is linked with various life-threatening diseases as discussed below. It is very difficult to remove these potent and hazardous metals from the environment as they cannot be degraded chemically and biologically. Bioremediation offers an economical approach to remove these contaminants. Bioremediation uses both live microorganisms as well as plants (Phytoremediation) for the removal of heavy metals. Among toxic heavy metals, cadmium is one such metal which is harmful to flora and fauna. The study shows the present concrete scenario as well as the previous findings in this field of remediation of potent heavy metals, especially cadmium, which is very...
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Posted by admin on Aug 31, 2019 in |
The aim of the present work was to develop and evaluate the potential of nanostructured lipid carriers (NLCs) loaded with Clobetasol-17-propionate (CP) as a new approach for the topical treatment of psoriasis. CP-loaded NLCs were prepared by melt emulsification and ultra-sonication method and optimized using 33 full factorial designs (Design-Expert software 11.0), by using solid lipid (compritol ATO 888) and liquid lipid (oleic acid) and Tween 80 as a surfactant. Drug loaded NLCs were evaluated for various parameters like particle size, surface charge, polydispersity index, entrapment efficiency, surface morphology, thermal analysis, in-vitro drug release through the skin (Franz diffusion cell), drug deposition study and stability. The optimized formulation has a particle size of 91.2 ± 2.37 nm, the zeta potential of -34.7 ± 1.49 mV, polydispersity index of 0.173 ± 0.035 and entrapment efficiency of 85.4 ± 2.89%. Release study demonstrated prolonged CP release from NLCs following Higuchi release kinetics with r2 = 0.9838, while pure CP suspension showed quicker drug release obeying zero-order kinetics with r2 value of...
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Posted by admin on Aug 31, 2019 in |
Osteoarthritis is accepted as the most growing, frequent, debilitating and heterogeneous condition that worsens the quality of life globally in the elderly, affecting an estimated 10% of men and 18% of women over 60 years of age with a rise in both prevalence and incidence. At present, there is no definite cure for osteoarthritis and no effective treatments which arrest or slow its progression; however multiple numbers of treatments ranging from newly approved oral medications, topical agents, intra-articular injections to surgery exist, but these treatments are sometimes disappointing and may have a detrimental effect on health. Hence, traditional plants appear to be efficacious and safe with the anti-osteoarthritic effect that aid for greater relief of symptoms and/or disability along with highlighting various phytochemical with scientifically proven, and validated. In this present review study, an effort is made to treat OA by focusing on the clinical, scientific and mechanistic rationale for targeting inflammatory signaling pathways in OA by use of traditional...
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Posted by admin on Aug 31, 2019 in |
Simple, sensitive, cost-effective and selective methods are designed and developed for the oxidative indirect spectrophotometric determination of drugs and pharmaceuticals, viz., Argatrobane Monohydrate (ARG), Bortezomib (BOR), Chloroquine Phospate (CHP), Granisetron HCl (GRA), Ibandronate Sodium (IBA) based on their reactivity towards n-bromo succinamide (NBS in excess). The method is based on the oxidation of drugs by n-bromo succinamide (excess) and estimating the amount of un-reacted NBS by Methyl Orange dye at λmax 508 nm. The calibration curves obeyed Beer’s law over the concentration range of 10-70 µg mL-1 (ARG), 8-56 µg mL-1 (BOR), 6-42 µg mL-1 (CHP), 4-28 µg mL-1 (GRA) & 5-35 µg mL-1 (IBA). This method has been applied for the determination of drugs in their pure form as well as in tablet formulations. Statistical analysis of the results using Student’s t-test for accuracy and F-test for precision revealed no significant difference between the proposed methods and the literature method at the 95% confidence level with respect to accuracy and precision. The method has been validated in terms...
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Posted by admin on Aug 31, 2019 in |
Diabetes, a chronic endocrine metabolic disorder, is managed using several anti-diabetic medications. Being a chronic disease requiring lifelong medications, the long-term safety profile and patient acceptance are crucial to achieving therapeutic success. The available medications are known to have common side effects such as hypoglycemia, weight gain, and gastrointestinal adverse effects. Uncommon adverse effects, although rare can be troublesome in some patients and may lead to decreased medication adherence/concordance and hence treatment failure. There are reports of metformin being associated with lactic acidosis and sulfonylureas with cholestatic jaundice. Piogliatazone can have a rare adverse effect of pulmonary edema with or without congestive heart failure. Acarbose can be the reason for ileus and sub ileus in patients. Glucagon-like peptide-1 receptor agonists like liraglutide can cause pancreatitis. Careful consideration of anti-diabetics while prescribing, adequate clinical and laboratory monitoring and proper counseling of patients might help in prevention and early detection of these rare but severe adverse effects of anti-diabetics....
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