Posted by admin on Aug 31, 2020 in |
Solubility plays a vital role in achieving the therapeutic efficacy of a drug from a dosage form. Advances in molecular screening techniques for identification of potential drug molecules investigated an increased number of new pharmacologically active lipophilic compounds that are poorly water-soluble about 40% of new chemical entities have been discovered as poorly water-soluble. Numbers of technical strategies have been investigated for improving bioavailability like solid dispersions, cyclodextrins, micronization, surfactants, nanoparticles, lipids, permeation enhancers, etc. It is a great task for a pharmaceutical scientists to formulate oral dosage forms of these drug candidates with sufficient bioavailability. Among the various approaches to improve the oral bioavailability of these drug candidates, self-dispersing lipid formu-lations is one of the approaches to improve the bioavailability of lipophilic drugs. Self-dispersing lipid formulations is a very broad area that covers self-emulsifying drug delivery system (SEDDS), Self-micro emulsifying drug delivery system (SMEDDS), Self-nano emulsifying drug delivery system (SNEDDS) as carrier systems that have been...
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Posted by admin on Aug 31, 2020 in |
The present aim study is the formulation development and evaluation of extended-release matrix tablets of oxybutynin chloride by using hydrophilic and hydrophobic matrix systems. The pilot-scale batches of nine formulations were prepared using Eudragit RSPO, Eudragit RLPO, Carbopol 971NF, ethylcellulose individually, and in the combination of above polymer and Avicel PH102 by adopting direct compression method. The fabricated matrix tablets were assessed for their physicochemical properties and in-vitro drug release study. The drug-excipient interaction was evaluated by Fourier transform infrared spectroscopy, where no such interactions were observed. The F1-F3 formulation batches containing Eudragit RSPO in different proportions showed an effective drug release of nearly 99% at 24 h. The F4-F6 formulation batches contained Eudragit RLPO in the diverse amount presented an impressive drug release of >97%. In batches F7-F9, the combination of Eudragit RSPO and Eudragit RLPO produced a remarkable drug release of 100%. The optimized formulation F3 demonstrated a comparative similarity factor ƒ2 and less difference factor ƒ1 with that of the marketed tablet. The formulation F3 also...
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Posted by admin on Aug 31, 2020 in |
Background: Tuberculosis (TB) is a global health burden and can cause potential infection in any system of the body. Pulmonary tuberculosis (PTB) is most common presentation, but the diagnosis of TB remains elusive because of none of biochemical or serological test is invalid. During the development of END TB strategy, the gene expert (CBNAAT) test was first endorsed by WHO. Materials and Methods: This was a prospective observational study; conducted in the Department of Microbiology, Baba Raghav Das Medical College, Gorakhpur Uttar Pradesh, India. All patients suspect of PTB fulfilling, inclusive criteria were enrolled for PTB confirmation. All kind of clinical samples pertaining to PTB were processed in TB laboratory for Ziehl-Neelsen stain microscopy, solid culture (Lowenstein-Jensen (L. J.) and gene expert. All data were collected and analyzed using SPSS ver. 2017. Results: During the study period, a total of 542 clinical PTB cases were enrolled. Among which distribution of clinical samples was (404/74.53% sputum, 104/19.18% gastric aspirate, 34/6.27% broncho-alveolar lavage: BAL). Among 542 total samples enrolled, 102 (18.81%)...
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Posted by admin on Aug 31, 2020 in |
Clobetasol propionate (CP) has anti-inflammatory, immunomodulatory, and anti-proliferative activity. The current work aimed to prepare and evaluate the nanoemulsions of CP loaded tea tree oil (TTO) would be stable nanoemulsion. Clinical use of CP is restricted to some extent due to its poor permeability across the skin. So, to increase its permeation across the skin, microemulsion based formulations were prepared and characterized. Microemulsions were prepared by aqueous phase titration method, using TTO, tween 20 transcutol P, and distilled water as the oil phase, surfactant, co-surfactant, and aqueous phase, respectively. Selected formulations were subjected to physical stability studies. Malven Zeta seizer did particle size distribution of nanoemulsion. In surface studies of the optimized formulation were done by Transmission Electron Microscopy. The nanoemulsion (A2) was a colloidal dispersion having average droplet size ranging from 100 to 200 nm. The nanoemulsion (A2) formulation exhibited a narrow size distribution (PI = 0.131). The optimized formulation exhibited viscosity 28.30 ± 1.91 mP, refractive index 1.403, pH 6.15, and conductivity 10-4 s cm-1. The optimized...
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Posted by admin on Aug 31, 2020 in |
Diabetes mellitus (DM) is a globally spreading metabolic disorder with a high incidence rate. About 425 million cases took place in 2017 and expected to rise up to 693 million by 2045. In diabetes, the patient elevation of blood glucose level occurs due to the deformation of insulin receptor action/secretion or both. Long term increases in blood glucose level causes chronic effects such as dysfunction and damage of various organs such as eyes, nerves, kidney heart and blood vessels. There are many treatment regimens available in market, but do not able to provide complete relief and cause severe side effects. To overcome these types of problems it becomes important to find different therapeutic targets and use it in combination with conventional medicine for the treatment of diabetes. To surmount the side effect of presently available treatments, now researchers relay on herbal plants. In this review, we discussed the diabetes occurrence, epidemiology, types, different target receptors, and available treatments and describe briefly role of different plant constituents in diabetes management...
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