Posted by admin on Aug 31, 2019 in |
Conventional oral dosage forms posses low bioavailability problems due to their rapid gastric transition from the stomach. Especially some drug which is less soluble in alkaline pH and producing local action in the stomach gets rapidly emptied and do not get enough residence time in the stomach. As a result, there is a requirement of increased frequency of dose. To overcome such type of problems various efforts have been made by developing the gastro-retentive drug delivery system. The gastro-retentive drug delivery system comprised mainly of floating, mucoadhesive, swellable and high-density systems have emerged as a current approach of enhancing the bioavailability and controlled delivery of drugs that exhibit an absorption window. So, oral controlled release and site-specific drug delivery system has been of great interest in the pharmaceutical field to achieve an improved therapeutic advantage. In this review, we have discussed the various approaches to produce gastro retention of drug delivery system, with special discussion on floating in-situ gel system for stomach specific drug delivery. As it offers several...
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Posted by admin on Aug 31, 2019 in |
Multifunctional excipients are class of excipients that includes pre-processed and co-processed excipients that provide added functionalities to the formulation. Functionality is a desirable property of the material that aids manufacturing and improves the quality and performance of the material. This review article reveals with the functionality evaluation of excipients that include surrogate functionality and explicit functionality of excipient. The surrogate functionality gives information that predicts whether or not a particular excipient is likely to have the requisite functionality to produce a product that will meet finished product specifications in all respects. The explicit functionality means the ability of excipient to develop an appropriate formulation of a drug and a useful manufacturing process to create a tablet. Compactibility of excipient is a capability of the material to form coherent agglomerates after compression, has been analyzed by compact density, tensile strength, solid fraction, bonding index, etc. The compatibility mainly depends upon the material property like plastic and...
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Posted by admin on Aug 31, 2019 in |
Planterosomal gel exhibit better pharmacokinetic and pharmacodynamic profile than the conventional herbal extracts. The objective of the present research work was to develop, characterize and evaluate the in-vitro antifungal activity of planterosomal gel in comparison to pure plant extract. Planterosomal gel of Ganoderma lucidum was prepared by incorporating gelling agent in planterosomal suspension. Planterosomal gel of G. lucidum was subjected to different evaluation parameters like pH, spreadability, in-vitro release study, ex-vivo permeation study, and in-vitro antifungal activity. Results of in-vitro release studies and ex-vivo skin permeation studies showed that the planterosomal gel releases the active ingredients in a controlled manner and showed higher skin permeability in comparison to G. lucidum gel. The optimized planterosomal gel showed moderate antifungal activity when compared with a standard antifungal agent. So, it was concluded that the planterosomal gel is an advanced form of herbal formulation which enhances the retention time and skin permeability when applied...
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Posted by admin on Aug 31, 2019 in |
Sumatriptan succinate is the 5H1 receptor agonist and used in the treatment of migraine, cluster headache. The main objective is to develop ideal anti-migraine nasal mucoadhesive microparticles as local and systemic drug delivery system. An attempt was made to formulate the nasal mucoadhesive microparticle of Sumatriptan succinate with excipients like mucoadhesive polymers i.e., HPMC, ethyl cellulose, etc., by using modified solvent evaporation method. And evaluated them for production yield, drug loading efficiency, surface morphology by SEM, drug content, particle size, in-vitro drug release studies. The release rates were studied using GraphPad Prism software. The prepared micro-particles of Sumatriptan succinate formulations were found to be satisfactory particle size i.e., in the range of 33.3 to 59.94 µm, mucoadhesion time of F5 found to be 321 min drug content was found to be 81.79 % to 89.16%, and drug release of the drug follows zero order kinetic model. Optimized formulation F5 shows that the developed formulations have shown improved dissolution profile in comparison to other formulation. The developed nasal mucoadhesive microparticles...
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Posted by admin on Aug 31, 2019 in |
Most of the simulation methods for soft tissue modeling involve tetrahedral meshes which is quite complex and takes much computation time. Instead, this work attempts to make use of delaunay triangulated mesh that consists of unique mathematical properties suited for simulating soft tissues. Although, triangulated mesh is not so complex yet effective in producing elements of good quality. It even reduces computation time compared to the tetrahedral mesh by providing more geometric flexibility. In virtual surgery, it is essential to model the layers of soft tissues of human skin to perform a simulation of deformation and removal of cells. Based on this the multilayered model of skin prototype is developed in a pre-process and used for interactive modeling. This work presents a simple method for performing real-time collision detection in a virtual surgery environment. Also shows the efficient computation of collisions between the scalpel and delaunay triangulated mesh using a local collision detection function. The framework incorporates qualitative results obtained towards the simulation of surgical deformation and removal of...
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