Posted by admin on Aug 31, 2024 in |
The primary cause of death for women with gynaecological cancer diagnoses is ovarian cancer. It is also, generally speaking, the sixth most common cause of death for women. The majority of cases had advanced diagnoses, which worsens the disease’s prognosis. The limited predictive value of the current screening tests adds even more suffering to the situation. The most important early detection techniques, which have not had a discernible positive impact on the morbidity or death of this malignancy, are comprehensive gynaecological evaluation, transvaginal ultrasonography, and laboratory markers such as the cancer antigen-125 (CA-125) assay. However, anti-angiogenic bevacizumab and Poly (ADP-ribose) polymerase (PARP) inhibitors have gained pace in the management of this condition. Traditionally, the treatment regimen involves surgery and platinum-based chemotherapy. Although the exact etiology of ovarian cancer is unknown, there are several factors that have been found to raise the risk of the illness. Experts understand that DNA alterations, or mutations, occur in ovarian cancer-causing cells when they originate within or close to the ovaries. The instructions that...
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Posted by admin on Aug 31, 2024 in |
Cytochrome P450 2D6 (CYP2D6) is an essential enzyme that affects the safety and effectiveness of a broad range of medications through its metabolism. We provide here an extensive in-silico investigation of new drug candidates that target CYP2D6. To find putative CYP2D6 inhibitors, we used virtual screening, structure-based drug design, molecular docking, and simulation approaches in the Biovia Discovery Studio 2022 framework. By maintaining ADMET and TOPKAT filters, a broad variety of small molecules were subjected to virtual screening. After that, the two chosen compounds, cmp1 and cmp13, were used in molecular docking studies against the 4WNU and 4XRZ proteins to evaluate binding affinities and interactions. For 2815 compounds, ADMET and TOPKAT profiling were done to get non-toxic molecules. The non-toxic molecules after filtrations were taken for the docking studies followed by molecular dynamic simulation of the best complex. The best two molecules after ADMET and TOPKAT profiling were taken for docking studies, where these results demonstrated several intriguing therapeutic options with high binding affinities and favorable interactions of compound cmp1...
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Posted by admin on Aug 31, 2024 in |
Oyster mushrooms are considered functional foods due to their structure. Our work focused on assessing the antioxidant power and determining the secondary metabolite content of mushroom teas formulated from the best-known, cultivated and eaten species. We carried out an ethnonutritional survey, and the species selected were used for the rest. We implemented a mixing plan after which 13 formulations were selected to prepare the various herbal teas. Pleurotus pulmonarius, Pleurotus ostreatus and Pleurotus floridanus were the most cultivated, known, and consumed species. DPPH test revealed that T5, T6 and T2 exhibited the best CI50: 17.39 ± 0.35b, 17.65 ± 1.20b, and 18.93 ± 0.31bc respectively compared to the standard which had a CI50 of: 3.09 ± 1.56a. In the FRAP test, T3, T9 and T11 displayed the best IC50 values: 7.72 ± 2.51b, 10.16 ± 0.14c, 11.00 ± 0.17cd, respectively, while the standard had an IC50 of 1.80 ± 1.06a. In the hydrogen peroxide test, T1, T3 and T4 had the best CI50 values: 23.44 ± 2.94b, 24.98 ±...
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Posted by admin on Aug 31, 2024 in |
Methotrexate (Mtx) is used to treat a number of conditions, including certain types of malignancy. Therefore, the purpose of this study was to investigate the potential protective impact of flavonoid quercetin on toxicity caused by methotrexate using hematological, biochemical, histopathological and oxidative stress approaches. There were four different groups, each group consisting of ten rats. The group 1 was a control, and animals were treated with 0.5 ml of carboxymethyl cellulose. Group 2 and 3 were treated with methotrexate (0.250 mg/kg); quercetin (50 mg/kg) and group 4 were treated with methotrexate (0.250 mg/kg) + quercetin (50 mg/kg). All drugs were given orally via oral gavage once daily for 28 days. At end of the trial, blood samples were collected from all of the animals for hematological, biochemical and oxidative stress parameters estimation. Following the animal’s sacrifice, organs were collected for histopathological examination. The levels of TP, ALB, renal indicators like BUN and creatinine and liver enzymes like AST, ALT, and ALP were markedly elevated by methotrexate at dose rate...
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Posted by admin on Aug 31, 2024 in |
Artificial Intelligence (AI) focuses on producing intelligent modelling, which helps in imagining knowledge, cracking problems and decision-making. Recently, AI played an important role in various fields of pharmacy like drug discovery, drug delivery formulation development, poly-pharmacology, hospital pharmacy, etc. In drug discovery and drug delivery formulation development, various Artificial Neural Networks (ANNs) like Deep Neural Networks (DNNs) or Recurrent Neural Networks (RNNs) are being employed. Several implementations of drug discovery have currently been analysed and supported the power of the technology in quantitative structure-property relationship (QSPR) or quantitative structure-activity relationship (QSAR). In addition, de novo design promotes the invention of significantly newer drug molecules with regard to desired/optimal qualities. In the current review article, the uses of AI in pharmacy, especially in drug discovery, drug delivery formulation development, poly-pharmacology and hospital pharmacy are...
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