Posted by admin on Aug 31, 2019 in |
The leaves of Coriandrum sativum commonly known as Cilantro and Petroselinum crispum commonly known as Parsley, family Apiaceae, have several health benefit effects. Most of the people, confused while buying these leaves. In the present study, comparative morphological, microscopic, fluorescence, TLC, and phytochemical parameters, comparative assessment of phenolic and flavonoid contents and in-vitro antioxidant activity of C. sativum and P. crispum leaves were carried out using standard methods. The leaves of these plants are morphologically similar, except other characteristics such as smells, number of lobes and serrate. The microscopic study showed the presence of different types of stomata, epidermis, fibers, and trichrome. Comparative fluorescence, ash content, LOD, and extractive content study were shown the distinct features. The total phenols and flavonoids of the leaves of P. crispum were higher than the leaves of C. sativum, and its antioxidant activity was also stronger than the leaves of C. sativum. The present comparative study reports the first time and can be useful for the identification or authentication of P. crispum and...
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Posted by admin on Aug 31, 2019 in |
Proteins interact in the cellular arena to carry out a majority of the vital functions of the cells. After exploring the transcriptome, the researchers are now targeting to investigate the interactome of a cell. This can help to design more efficient drug and vaccine formulations and therapeutic targets benefiting humankind in every possible way. Advancement in protein and protein networking databases gives the first insight to study such macromolecular interactions paving the way for their in-vitro and in-vivo analysis. However, none of the technique can promise 100% efficiency alone due to some limitations like time, cost, and false positive results. Combination of one or more techniques can enhance data quality and reliability. Recent advancements in the studies of the protein-protein interaction using computational methods have led the identification of different signaling pathways and protein complex involved in various specific diseases. However, the major challenge faced is to verify the results obtained from the virtual prediction software’s. In this review, we have focused on how different techniques have been accustomed...
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Posted by admin on Aug 31, 2019 in |
The plant Knema attenuata or Myristica attenuata (Myristicaceae) is an endemic tree species found in the Western Ghats. Traditionally, the stem bark of K. attenuata is used in folk medicine without any scientific information available for the same. Phytochemical screening was carried out for ethanolic stem bark extract of K. attenuata to investigate the antioxidant potential of the extract. The antioxidant activity of the extract was estimated employing in-vitro models: DPPH radical scavenging assay, total antioxidant activity, nitric oxide scavenging assay and reducing power activity. The extract was found to be rich in phenolics, alkaloids, and flavonoids. Quantitative estimation of extract demonstrated higher levels of phenolics and flavonoids. The extract exhibited significant radical scavenging activity and a total antioxidant capacity compared with that of ascorbic acid (Standard) which confirms the use of the species in folk...
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Posted by admin on Aug 31, 2019 in |
Objective: Studies have shown that sorafenib an anti-cancer agent has a neuroprotective effect. This study evaluated the neuroprotective activity of sorafenib in 6-OHDA induced rat model of Parkinson’s disease. Methods: 6-OHDA was injected into the forebrain bundle through the stereotaxic apparatus to induce fast and severe degeneration in dopaminergic neurons of substantianigra. The animals were divided into four groups. Group I- vehicle control, Group II- 6-OHDA induced, Group III- 6- OHDA + Levodopa (6 mg/kg), Group IV- 6-OHDA + sorafenib (10 mg/kg s.c). Treatment was given for 21 days after induction of 6-OHDA. The animals were subjected to behavioral parameters such as apomorphine-induced rotations, grip strength, catatonia and biochemical parameters such as total protein estimation, reduced glutathione, lipid peroxidase, calcium concentration in the brain. Results: Sorafenib significantly decreased the apomorphine-induced rotations as well as catatonia and significantly increased (p<0.001) the grip strength when compared to 6-OHDA. In biochemical estimation total protein and glutathione is increased (p<0.001). Both lipid peroxidase and calcium level have been decreased significantly (p<0.001) when compared...
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Posted by admin on Aug 31, 2019 in |
Surface disinfectant is the multi-billion-dollar global industry with continuous growth opportunities linked to advancements in technology and innovations. However, innovations and new advancements do not always reach consumers due to the lack of clarity related to the approval process of such innovations and stringent regulations by national health authorities. These regulations can pose challenges for innovators, manufacturers, importers & exporters to obtain market authorizations. This article provides an overview of the disinfectant regulations globally and understands the need for...
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