Posted by admin on Aug 31, 2019 in |
Selecting the best possible design is an uphill task considering a lot of criteria which must be scrutinized while choosing any design out of many alternative design options available. The experimental design is often compared and selected based on alphabetical design optimality criteria, like A, D, G or V. Each of them attempts to summarize any one important characteristic of the selected design. G-optimality criteria favor those experimental designs which are having the smallest maximum prediction variance over the entire region of interest. It does not consider the distribution of the magnitude of the prediction variance throughout the region. Graphical methods like variance dispersion graph and the fraction of design space plots can be used to overcome this drawback. These graphical methods are explored extensively for comparing the quality of prediction throughout the design space. It serves as a useful tool to assess the prediction performance of the design and making a comparison between experimental designs. The fraction of the design space plot provides a comprehensive picture of the...
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Posted by admin on Aug 31, 2019 in |
In this present investigation author reporting the anti-bacterial activity of five new azo methines, namely 2-((1-hydroxy-2- methyl propan-2-ylimino) methyl)-6-methoxyphenol (AZM1), 4-((1-hydroxy-2- methyl propan-2-ylimino) methyl)-6-methoxyphenol(AZM2), 4-((1-hydroxy-2-methyl propan-2-ylimino) methyl)-2,6,dimethxy phenol (AZM3), 2- (3, 4- dimethoxybenzylideneamino)- 2- methylpropan-1-ol (AZM4) and 2-(3,4,5-trimethoxybenzylideneamino)-2-methylpropan-1-ol (AZM5) against and Bacillus thuringiensis, E. coli bacteria. All new five novel Azomethines were synthesized by the condensation of 2-Amino-2-Methyl-1-Propanol with 2- Hydroxy- 3- methoxybenzaladehyde, 4-Hydroxy- 3- Methoxy-Benzaldehyde, 4- Hydroxy- 3, 5- Dimethoxy Benzaldehyde, 3,4-Dimethoxy Benzaldehyde and 3, 4, 5-Trimethoxy Benzaladehyde respectively, in methanol-water (1:1 ratio) at 42 ºC for 8 h. All the azomethines were characterized by UV, IR and thermal elemental analyzer. Anti-bacterial studies were carried out by using Paper disc diffusion method, beef extract is used as bacterial source, chloromphenicol and ketocanazole used as reference standards, five azomethines gave the following order of antibacterial activity and order of zone of inhibition was AZM5 (12mm) > AZM4 (7mm) > AZM3 (10mm) > AZM1 (9mm) > AZM2 (8mm) against E. coli and AZM5 (11mm) > AZM4 (10mm) > AZM3 (9mm)...
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Posted by admin on Aug 31, 2019 in |
Probiotics are live microorganisms that when introduced orally positively contribute to the activity of the intestinal microflora and the health of its host. Various studies showed that probiotics are potentially able to contribute to treatments of many diseases. They may not cure any disease, but can significantly improve the patient’s condition and also can prevent many infections. Recent studies confirmed that gut microbiota has a direct connection to the behavior and development of the brain. This review is done in two parts. The first part discusses how micro-encapsulation can improve targeted delivery of probiotics where second part discusses the effects of probiotics on various diseases. On the first half of this review, we will see micro-encapsulation allows core ingredients or probiotics to be separated from the environment by a protective coating which can enhance shelf-life of probiotics. The objective of this review is to study the efficiency of different encapsulation materials and methods to understand and control the delivery of probiotic by the conventional method to improve drug uptake,...
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Posted by admin on Aug 31, 2019 in |
The fabrication of spherical gold nanoparticles (AuNPs) using the reducing agent and stabilizing agent Coccinia grandis is reported here. Irradiation of the reaction mixture under a domestic microwave oven enabled the formation of gold nanoparticles. The successful formations of AuNPs were characterized by UV-Visible spectroscopy (UV-Vis), Fourier transforms infrared spectroscopy (FTIR), X-ray powder diffraction and transmission electronic microscopy (TEM). Chemical components are inherent in the leaf extract which reduces the gold were identified using FTIR Spectra. The crystal structure of the AuNPs was established as a face-centered cube by the Powder XRD analysis. TEM results suggested that under optimized synthetic conditions monodispersed and spherical nanoparticles with an average diameter of 10 ± 2 nm could be achieved. The nanoparticles effectively showed catalytic activity for the reduction of environmental pollution causing methylene blue dye. The study concludes that the synthesized nanoparticles could be considered as environmental protectants due to its potent catalytic...
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Posted by admin on Aug 31, 2019 in |
Gliflozin drugs is the sodium-glucose co-transporter 2 inhibitor is the newly developed class of oral hypoglycaemic agents used for the treatment of the type-II diabetes mellitus. This class approved by food and drug administration in 2013 for the treatment of diabetes, with a unique mechanism of action. SLGT-2 proteins are macromolecule reabsorb the filtered glucose molecule from (PCT) in the kidney. This class of drugs block SGLT-2 protein from the site of the proximal convoluted tubule (PCT) in the kidney, resulting in prevent reabsorption of a glucose molecule and allow excretion of glucose molecule through urine. By this mechanism, the gliflozins drug lowers the blood glucose level in the body.SGLT-2 inhibitors are the newest class of anti-diabetic drugs grab more attention when it is used in combination with insulin and other anti-diabetic drugs. Gliflozins shows various adverse effect such as ketoacidosis, urinary tract infection, bone fracture, and foot and leg amputation. This article explained pathogenesis and pathophysiology of type-II diabetes mellitus with a detailed mechanism of action of a...
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