Posted by admin on Aug 31, 2019 in |
Albizia procera is a genus of albizia, the member of legume family (fabaceae) and subfamily Mimosoideae. Albizia procera is tree with open canopy, occurs naturally in a wide distribution from India and Myanmar through South-East Asia to Papua New Guinea and Northern Australia. On basis of our study, Albizia procera has the high economic potential to be applied in pharmaceuticals, pharmacognosy, traditional medicines, agricultures, tanning, dyeing, construction, ornamental markets, and so many researchers identified more pharmacological activities in Albizia procera were used in humans. This review presents phytochemical constituents, pharmacognostic characters, traditional uses, pharmacological and biological activities reported for the plant and it will be helpful to explore the knowledge about Albizia procera for the...
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Posted by admin on Aug 31, 2019 in |
Alcohol use disorders (AUDs) recognized as substantial public health problem. It is grown-up many risk factors influence on alcoholism including social, behavior, an environment, and heredity conditions on the global. Alcuremon preparation was based on medicinal herbs and used for the treatment of alcohol-related disease and alcoholic liver disease in traditional Mongolian medicine. Male Wistar rats were used to induce alcoholic liver disease and chronic ethanol (EtOH) intoxication with neurotransmitter imbalance by oral administration of ethanol (subchronic 30% EtOH 10 ml/kg/day for 14 days and chronic 40% EtOH 7 ml/kg/day for 60 days). Alcuremon 50, 100 and 150 mg/kg were given orally for the same day as ethanol administration days. Some biochemical parameters and liver HE stains were examined in subchronic intoxication with alcoholic liver disease. Chronic ethanol-induced neurotransmitters changes were measured by enzyme-linked immunosorbent assay (ELISA) in brain homogenate of nucleus accumbens (NAc) and ventral tegmental area (VTA). Hippocampus was stained with cresyl violet. Data were expressed as mean ± SD. The difference between the groups was compared...
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Posted by admin on Aug 31, 2019 in |
Background: The association between metabolic syndrome and cognitive impairment is not well established. The aim of the present study was to estimate the prevalence of cognitive impairment in adults with metabolic syndrome (MetS). Methods: Cross-sectional observational study conducted in patients with metabolic syndrome (n=185). All patients were subjected to written informed consent, anthropometric measurements, neuropsychological assessments using Mini-Mental State Examination (MMSE). MetS was diagnosed using the definition by the National Cholesterol Education Program- Third Adult Treatment Plan. The main outcome measure was cognitive impairment (<24 on the MMSE scale). Mean, standard deviation and students t-test were used to carry out the analyses. Results: The prevalence of cognitive impairment in MetS patients was 24%. Patients age ranged between 20-75 years and 45% (n= 83) of them were female. MMSE scores were lower in female patients compared to male, however, the difference was not significant (p=0.06). College graduates had significantly higher MMSE scores than patients with just a high school education (p<0.05). Patients with high levels of triglycerides had significantly lower...
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Posted by admin on Aug 31, 2019 in |
The Increase in industrialization has raised the levels of heavy metal pollution in the country. Heavy metals are entering through the water supply, which is ultimately reaching into streams, lakes, rivers, and groundwater. So, ultimately, these heavy metals are causing environmental pollution, which is becoming a threat to humans as well as animals as the heavy metal pollution is linked with various life-threatening diseases as discussed below. It is very difficult to remove these potent and hazardous metals from the environment as they cannot be degraded chemically and biologically. Bioremediation offers an economical approach to remove these contaminants. Bioremediation uses both live microorganisms as well as plants (Phytoremediation) for the removal of heavy metals. Among toxic heavy metals, cadmium is one such metal which is harmful to flora and fauna. The study shows the present concrete scenario as well as the previous findings in this field of remediation of potent heavy metals, especially cadmium, which is very...
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Posted by admin on Aug 31, 2019 in |
The aim of the present work was to develop and evaluate the potential of nanostructured lipid carriers (NLCs) loaded with Clobetasol-17-propionate (CP) as a new approach for the topical treatment of psoriasis. CP-loaded NLCs were prepared by melt emulsification and ultra-sonication method and optimized using 33 full factorial designs (Design-Expert software 11.0), by using solid lipid (compritol ATO 888) and liquid lipid (oleic acid) and Tween 80 as a surfactant. Drug loaded NLCs were evaluated for various parameters like particle size, surface charge, polydispersity index, entrapment efficiency, surface morphology, thermal analysis, in-vitro drug release through the skin (Franz diffusion cell), drug deposition study and stability. The optimized formulation has a particle size of 91.2 ± 2.37 nm, the zeta potential of -34.7 ± 1.49 mV, polydispersity index of 0.173 ± 0.035 and entrapment efficiency of 85.4 ± 2.89%. Release study demonstrated prolonged CP release from NLCs following Higuchi release kinetics with r2 = 0.9838, while pure CP suspension showed quicker drug release obeying zero-order kinetics with r2 value of...
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