Posted by admin on Aug 31, 2019 in |
Osteoarthritis is accepted as the most growing, frequent, debilitating and heterogeneous condition that worsens the quality of life globally in the elderly, affecting an estimated 10% of men and 18% of women over 60 years of age with a rise in both prevalence and incidence. At present, there is no definite cure for osteoarthritis and no effective treatments which arrest or slow its progression; however multiple numbers of treatments ranging from newly approved oral medications, topical agents, intra-articular injections to surgery exist, but these treatments are sometimes disappointing and may have a detrimental effect on health. Hence, traditional plants appear to be efficacious and safe with the anti-osteoarthritic effect that aid for greater relief of symptoms and/or disability along with highlighting various phytochemical with scientifically proven, and validated. In this present review study, an effort is made to treat OA by focusing on the clinical, scientific and mechanistic rationale for targeting inflammatory signaling pathways in OA by use of traditional...
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Posted by admin on Aug 31, 2019 in |
Simple, sensitive, cost-effective and selective methods are designed and developed for the oxidative indirect spectrophotometric determination of drugs and pharmaceuticals, viz., Argatrobane Monohydrate (ARG), Bortezomib (BOR), Chloroquine Phospate (CHP), Granisetron HCl (GRA), Ibandronate Sodium (IBA) based on their reactivity towards n-bromo succinamide (NBS in excess). The method is based on the oxidation of drugs by n-bromo succinamide (excess) and estimating the amount of un-reacted NBS by Methyl Orange dye at λmax 508 nm. The calibration curves obeyed Beer’s law over the concentration range of 10-70 µg mL-1 (ARG), 8-56 µg mL-1 (BOR), 6-42 µg mL-1 (CHP), 4-28 µg mL-1 (GRA) & 5-35 µg mL-1 (IBA). This method has been applied for the determination of drugs in their pure form as well as in tablet formulations. Statistical analysis of the results using Student’s t-test for accuracy and F-test for precision revealed no significant difference between the proposed methods and the literature method at the 95% confidence level with respect to accuracy and precision. The method has been validated in terms...
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Posted by admin on Aug 31, 2019 in |
Diabetes, a chronic endocrine metabolic disorder, is managed using several anti-diabetic medications. Being a chronic disease requiring lifelong medications, the long-term safety profile and patient acceptance are crucial to achieving therapeutic success. The available medications are known to have common side effects such as hypoglycemia, weight gain, and gastrointestinal adverse effects. Uncommon adverse effects, although rare can be troublesome in some patients and may lead to decreased medication adherence/concordance and hence treatment failure. There are reports of metformin being associated with lactic acidosis and sulfonylureas with cholestatic jaundice. Piogliatazone can have a rare adverse effect of pulmonary edema with or without congestive heart failure. Acarbose can be the reason for ileus and sub ileus in patients. Glucagon-like peptide-1 receptor agonists like liraglutide can cause pancreatitis. Careful consideration of anti-diabetics while prescribing, adequate clinical and laboratory monitoring and proper counseling of patients might help in prevention and early detection of these rare but severe adverse effects of anti-diabetics....
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Posted by admin on Aug 31, 2019 in |
Benzofuranone is a bicyclic ring where a benzene ring fused with a furanone. Synthetic chemistry plays a major in developing a series of potent anti-cancer agents. Bromophenyl acetonitrile was prepared from phenyl acetonitrile by bromination at an alpha position which yielded bromophenyl acetonitrile which was a lachrymator compound. Benzofuranone was synthesized by reacting benzene diols and triols with bromo phenyl acetonitrile yielded an imine derivative are converted to a ketone with treatment with hydrochloric acid then cyclized with sodium acetate. The compounds identity and purity are confirmed by spectral and analytical methods. Benzofuranone derivatives are screened anti-neoplastic activity was performed against human skin cancer cell line G361 at micro molecular concentrations. The compounds IA, IB, ID, IE, IF, IIB, IIC, IIIA, IVB, IVF, VA, VC, VD, VE was found to be with potent activity. These compounds exhibited an excellent activity while compared to reference standard doxorubicin at different micromolar concentrations as such of the synthesized...
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Posted by admin on Aug 31, 2019 in |
The concept of quality by design (QbD) justifies the saying that, quality is not an act, it is a habit. This innovative and systematic approach to pharmaceutical development based on scientific principles has been a breakthrough in developing quality products with a high level of reproducibility. The process of QbD is based on risk management which leads to a better understanding of the product and its manufacturing process, resulting in products with required quality, safety, and efficacy. As the quality and reliability requirements of today’s world are constantly increasing, QbD serves as an important tool in outperforming the global competition. This paper comprehensively discusses the concept of pharmaceutical quality by design, elements of QbD; quality target product profile (QTPP), critical quality attributes (CQAs), design space, control strategy, and lifecycle management. Application of QbD across various fields of pharmaceutical development including formulation development, analytical method development, phytopharmaceutical & biopharmaceutical product development are encompassed in the...
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