Posted by admin on Aug 31, 2019 in |
Surface disinfectant is the multi-billion-dollar global industry with continuous growth opportunities linked to advancements in technology and innovations. However, innovations and new advancements do not always reach consumers due to the lack of clarity related to the approval process of such innovations and stringent regulations by national health authorities. These regulations can pose challenges for innovators, manufacturers, importers & exporters to obtain market authorizations. This article provides an overview of the disinfectant regulations globally and understands the need for...
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Posted by admin on Aug 31, 2019 in |
Ethno-medicinal plants have a significant role in the field of natural product research and drug discovery since ancient times. Drymaria cordata (L.) Willd. Ex Schult. belongs to the family Caryophyllaceae is an ethnomedicinal plant used as a home remedy in jaundice by the tea tribes of erstwhile Nagaon district of Assam. The present study deals with the evaluation of the phytoconstituents of Drymaria cordata using methanol extract. All the standard phytochemical procedures were followed for the detection of the phytoconstituents. The preliminary phytochemical screening revealed the occurrence of alkaloids, flavonoids, phenols, tannins and saponins. The presence of O-H stretch, C-O stretch, C-H stretch, C-H bend, N-H stretch and N-H bend were confirmed through FT-IR analysis. Several bioactive compounds like Cyclohexan-1,4,5-triol-3-one-1-carboxylic acid, Beta-D-glucopyranose-1,6-anhydro, L-gala-L-ido-octose, 3, 7, 11, 15-Tetra-methyl-2-hexadecen-1-ol, n-Hexadecanoic acid, 9, 12 Octadecadienoic acids (Z,Z)-, 9,12-Octadecadienoic acid, methyl ester, Oleyl alcohol and 17-Octadecynoic acid were identified through GC-MS analysis. From this study, it can be concluded that Drymaria cordata possesses several medicinally important secondary metabolites. Further phytochemical and pharmacological investigations...
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Posted by admin on Aug 31, 2019 in |
Amantadine hydrochloride (1), a well-known antiviral drug, has been used to treat certain type-A influenza infections and been also medicated as an anti-dyskinetic agent for Parkinson’s disease. In this paper, we report a simple and economical procedure for synthesis of amantadine hydrochloride (1) from 1-bromoadamantane (3) and urea in a one-step procedure with high yield (81%) and advantage. The structure of the obtained amantadine hydrochloride was confirmed by MS, 1H-NMR and 13C-NMR spectra and its quality was validated following the United State Pharmacopeia (USP 38). In addition, the synthesis condition was optimized following parameters including reaction reagent as source of nitrogen, reaction temperature, reaction time, reagent molar-ratio, solvent and HCl concentration, successively, to archive the highest yield of amantadine hydrochloride (1) at the following certified condition: reaction temperature = 175°C; reaction time = 1.0 h; molar ratio of (urea: 1-bromo-adamantane) = (3 : 1), in diphenyl ether with ratio of (Ad-Br : Ph2O) = 1.1 g :1 mL),...
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Posted by admin on Aug 31, 2018 in |
Intravenous administration of 5-Fluorouracil (5FU) produces severe systemic, dose-related side effects due to its cytotoxic nature, additionally, 5FU is rapidly absorbed from the stomach after oral administration. Therefore a combined floating-bioadhesive tablet (FBT) of 5FU has been developed in order to reduce the dose and associated side effects in other sites of the body. The tablets were prepared by direct compression technique. Hydroxy propyl methyl cellulose (HPMC) K15M was used as a release retardant polymer while carbopol-971P, guar gum and sodium alginate were used as bioadhesive polymer. The pre-compression characteristics shown fair flow behaviour and core tablet properties were within the Pharmacopoeia limit. All formulation batches reported satisfactory floating lag time in a range of 125 – 500 sec and remained buoyant for more than 6 h. Kinetics of dissolution data demonstrated that formulation batch FB4, FB9 and FB10 follow Korsmeyer-Peppas model, FB11 follows first-order kinetics; and FB1, FB2, FB3, FB5, FB6, FB7, FB8, FB12 and FB13 follows Higuchi Matrix model. Analysis of the data revealed that formulation batch...
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Posted by admin on Aug 31, 2018 in |
Free radicals are molecules with an unpaired electron that very unstable and react quickly with other compound to gain stability. Once the process is started, it can be a cascade reaction resulting disruption of a living cell. The free radicals formed in our body are combated by antioxidants then interact with free radicals and terminate the chain reaction before vital molecules are damaged. Moringa oleifera leaf extract well known can be as a source of antioxidant since it contains flavanoids for reducing free radical. This study was design to produce a crude extract of dark green and bright green of M. oleifera leaves using different solvent to determine its antiaging effect in male mice Mus musculus Swiss Webster. The antioxidant capacity of the extract were carried out using TMAMQ (Tetramethoxy Azobizmethylene Quinon) and ABTS (2, 2-Azino-bis (3-ethyl-benzothiazoline-6-sulfonic acid) method, while the antiaging activity were assessed by histological approach. The results showed that the highest antioxidant capacity was achieved by dark green M. oleifera leaves ethanolic extract followed by double-destilated...
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