Posted by admin on Aug 31, 2019 in |
Planterosomal gel exhibit better pharmacokinetic and pharmacodynamic profile than the conventional herbal extracts. The objective of the present research work was to develop, characterize and evaluate the in-vitro antifungal activity of planterosomal gel in comparison to pure plant extract. Planterosomal gel of Ganoderma lucidum was prepared by incorporating gelling agent in planterosomal suspension. Planterosomal gel of G. lucidum was subjected to different evaluation parameters like pH, spreadability, in-vitro release study, ex-vivo permeation study, and in-vitro antifungal activity. Results of in-vitro release studies and ex-vivo skin permeation studies showed that the planterosomal gel releases the active ingredients in a controlled manner and showed higher skin permeability in comparison to G. lucidum gel. The optimized planterosomal gel showed moderate antifungal activity when compared with a standard antifungal agent. So, it was concluded that the planterosomal gel is an advanced form of herbal formulation which enhances the retention time and skin permeability when applied...
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Posted by admin on Aug 31, 2019 in |
Sumatriptan succinate is the 5H1 receptor agonist and used in the treatment of migraine, cluster headache. The main objective is to develop ideal anti-migraine nasal mucoadhesive microparticles as local and systemic drug delivery system. An attempt was made to formulate the nasal mucoadhesive microparticle of Sumatriptan succinate with excipients like mucoadhesive polymers i.e., HPMC, ethyl cellulose, etc., by using modified solvent evaporation method. And evaluated them for production yield, drug loading efficiency, surface morphology by SEM, drug content, particle size, in-vitro drug release studies. The release rates were studied using GraphPad Prism software. The prepared micro-particles of Sumatriptan succinate formulations were found to be satisfactory particle size i.e., in the range of 33.3 to 59.94 µm, mucoadhesion time of F5 found to be 321 min drug content was found to be 81.79 % to 89.16%, and drug release of the drug follows zero order kinetic model. Optimized formulation F5 shows that the developed formulations have shown improved dissolution profile in comparison to other formulation. The developed nasal mucoadhesive microparticles...
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Posted by admin on Aug 31, 2019 in |
Most of the simulation methods for soft tissue modeling involve tetrahedral meshes which is quite complex and takes much computation time. Instead, this work attempts to make use of delaunay triangulated mesh that consists of unique mathematical properties suited for simulating soft tissues. Although, triangulated mesh is not so complex yet effective in producing elements of good quality. It even reduces computation time compared to the tetrahedral mesh by providing more geometric flexibility. In virtual surgery, it is essential to model the layers of soft tissues of human skin to perform a simulation of deformation and removal of cells. Based on this the multilayered model of skin prototype is developed in a pre-process and used for interactive modeling. This work presents a simple method for performing real-time collision detection in a virtual surgery environment. Also shows the efficient computation of collisions between the scalpel and delaunay triangulated mesh using a local collision detection function. The framework incorporates qualitative results obtained towards the simulation of surgical deformation and removal of...
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Posted by admin on Aug 31, 2019 in |
Lung cancer is one of predominant cancer which leads to death in the developed and developing countries. 80% of lung cancer cases in India are reported as Non-Small Cell Lung Cancer (NSCLC). EGFR (Epidermal growth factor receptor) that belongs to the tyrosine kinase family (RTKs) is the key paradigm of molecular targeted therapy of lung cancer. Garlic (Allium sativum) is a common Indian spice that belongs to the Allium family, is capable of allowing cancer cell death normally, the process called apoptosis. The therapeutic effect of garlic is due to the presence of its bioactive constituents, including the organosulfur compounds and flavonoids. Molecular docking studies using AutoDock provide the comprehensive binding of bioactive compounds of garlic with EGFR that may lead to its effective inhibition. The current study paves the way for understanding the binding of garlic’s bioactive compounds against EGFR, and it can act as a potential lead molecule for the development of anti-cancer...
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Posted by admin on Aug 31, 2019 in |
Background: This study aims to correlate the ankle/brachial index (ABI) with the severity of diabetic retinopathy in type 2 diabetic patients. Material and Methods: A hospital-based prospective study of 100 types 2 diabetic patients aged 40 to 80 years were recruited from the outpatient department. Ankle/brachial index scores and the presence and stage of diabetic retinopathy were assessed and analyzed. Results: Significant associations between abnormal ABI score and severe diabetic retinopathy (p<0.05) was found. Conclusion: Patients with abnormal ankle/brachial index were more likely to have severe diabetic retinopathy and were at increased risk of losing their sight, mandating fundus evaluation in such cases for timely intervention to safeguard the vision of the...
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