Posted by admin on Aug 31, 2018 in |
Cerebral palsy is main general motor disability in the infancy and 2 to 2.5 per 1000 live births affected by the cerebral palsy. The movement restrictions in the cerebral palsy are credited to non-progressive interruption that occurs in developing brain of the infants. It is characterized by means of spasticity, weakness of muscle, primitive reflexes loss, interfering of growth of normal motor control. The motor disorders of the cerebral palsy are frequently accompanied as a result of disturbances of the cognition, sensation, perception, communication and behaviour. The frequent threat factors are, multiple pregnancy, prematurity, small-for-gestational age and infections of the maternal genitourinary. The causal pathways, classification of cerebral palsy and prognostication can play a role in development to prevent the cerebral palsy and arrangement of health services to assemble the desires of the affected infants with disease. This paper covers the causes, clinical features, types, risk factors, pathophysiology and complications of cerebral...
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Posted by admin on Aug 31, 2018 in |
Buccal tablets are prepared by direct compression method using different polymers like carbopol, hydroxypropyl methylcellulose and sodium alginate. Nine formulations were prepared while (F1) to (F3) were prepared by taking individual concentrations whereas all the remaining formulations were prepared by taking combinations of polymers. Aim of study is to develop and optimize mucoadhesive buccal tablets of candesartan by direct compression method. All the batches were evaluated for thickness, weight variation, hardness and content uniformity. In-vitro release study is carried and release mechanisms were explored. Individual carbopol concentration (F1) has high swelling index with low water absorption ratio. Individual concentration of sodium alginate (F3) obtained high drug release, while low concentration of carbopol and high concentration of hydroxypropyl methylcellulose in combinations (F4) gave 86% drug release and with equal ratios of carbopol and hydroxypropyl methylcellulose (F7) gave 88% drug release. But low concentration of hydroxypropyl methylcellulose and high concentration of sodium alginate (F5) in combination form gave 95% drug release. While equal ratios of both hydroxypropyl methylcellulose and sodium alginate...
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Posted by admin on Aug 31, 2018 in |
Background: Metabolic syndrome has a significant impact on the severity and prognosis of various risk factors that may contribute to cardiovascular events. We examined the clinical profile and prevalence of MetS among MI patients along with the estimation of associated risk factors and determined the components of the MetS which conferred the paramount cardiovascular risk. Methods: A prospective observational study was conducted for duration of 10 months on a total of 117 MI patients who were further categorized based on IDF criteria for MetS at a tertiary care hospital in India. Statistical analysis of collected data was done using SPSS 22 for windows version. Results: Among all the parameters used for defining MetS, positive predictive value was highest for fasting blood sugar (p=0.001) followed by high blood pressure (p=0.005) and elevated triglycerides (p=0.850). MetS was significantly more prevalent in MI patients with a prevalence of 51.28% (p<0.001). Conclusion: The study depicted high prevalence of MetS among MI patients which implies greater risk of developing cardiovascular diseases. A systematic approach...
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Posted by admin on Aug 31, 2018 in |
A series of (Z)-3-((1H-benzo[d]imidazol-2-yl)methyl)-substituted thiazolidine-2,4-dione (9a-n) have been synthesized and evaluated for their mycobacterium inhibitory activity against Mycobacterium tuberculosis H37Rv strain. The structures of the newly synthesized compounds were characterized by FTIR and NMR spectral analysis. Most of the synthesized compounds showed moderate to good anti-tubercular activity. Among these compounds 9a, 9d, 9f and 9g have displayed good anti-tubercular activity (MIC 6.25 μg/ml). Further, the molecular docking studies were carried out in order to rationalze the biological...
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Posted by admin on Aug 31, 2018 in |
A simple, economical, accurate and precise high performance liquid chromatographic method was developed and validated for the determination of rifabutin. A Shimadzu LC-2010C HT version 3.01 system using a C-18 column with dimensions of 250 × 4.6 mm and silica particle size of 5 μm. Isocratic elution was employed with methanol, acetonitrile and water (75:25 v/v) were used. The flow rate was 1 ml/min, and effluents were monitored at 242 nm. The HPLC method was extensively validated for linearity, accuracy, precision (Interday precision, Intraday precision), repeatability and robustness. The exalted results receive of a drug were procured all significance values were established to be under the acceptable range in International Conference of Harmonization (ICH) guidelines requirements. The results demonstrate that the developed HPLC modus could be successfully used up for identification and quantification of Rifabutin in any form of the drug, with high resolution, accuracy, and...
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