Posted by admin on Aug 31, 2017 in |
In recent years more people throughout world are turning to use medicinal plant products in healthcare system. Worldwide need of alternative medicine has resulted in growth of natural product markets and interest in traditional systems of medicine. Proper integration of modern scientific techniques and traditional knowledge is important. There is a growing focus on the importance of medicinal plants in the traditional health care system (viz. Ayurveda, Unani, Homoeopathy, Yoga) in solving health care problems. Systematic approach and well-designed methodologies for the standardization of herbal raw materials and herbal formulations are developed. The stability testing of herbal products check the quality of herbal products which varies with the time under the influence of environmental factors, such as temperature, humidity, light, oxygen, moisture, other ingredient or excipient in the dosage form, particle size of drug, microbial contamination, trace metal contamination, leaching from the container, etc. and also provide statistics for the determination of shelf lives. Therefore evaluation of the parameters based upon chemical, physical, microbiological, therapeutic and toxicological studies can...
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Posted by admin on Aug 31, 2017 in |
Retinoids are the derivatives of Vitamin A and have similar action to that of Vitamin A. Sources of Vitamin A such as eggs and meat are known to contain a chemical, retin-A which is known to be useful for treating various dermatological disorders. Tretinoin, a first generation retinoid was first used orally for the treatment of acne in 1940s. Topical tretinoin was later developed as a result of potential adverse effects when given orally and it showed promising therapeutic effect for keratinizing disorders such as actinic keratosis and ichthyosis. Other systemic retinoids such as isotretinoin, acitretin and bexarotene were also studied consecutively which gained approval from US-Food and Drug Administration for a number of keratinisation disorders like acne vulgaris, psoriasis and mycosis fungoides respectively. Along with these disorders, systemic retinoid are widely used for various off label dermatological conditions but due their potentially serious adverse effects, their use has been contraindicated in a number of conditions, especially for pregnant women where it is reported to cause serious embryo-foetal abnormalities....
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Posted by admin on Aug 31, 2017 in |
Purpose: To formulate and characterize the bi-layer tablet of doxycycline immediate release and flurbiprofen sustained release. Method: Bi-layer tablets were formulated by wet granulation method. Ethyl cellulose and HPMC K 100 were used as polymer for sustained release layer. Five immediate release formulations were developed with varying excipients. Bi-layer tablets were evaluated by pre formulation and post formulation parameters as stated by USP. Dissolution was conducted in 0.1 N HCl and 6.8 phosphate buffer and resulting data were analyzed statistically by one way ANOVA and drug release kinetics was studied using various pharmacokinetic models. Results: Data from pre formulation confirmed the purity of doxycycline hyclate and flurbiprofen. FTIR confirmed the absence of incompatibility between drugs and excipients. Dissolution profile in 0.1 N HCl and 6.8 phosphate buffer was according to USP guidelines. Regression coefficient (R2) values from kinetic analysis showed that release followed Higuchi model indicating release mechanism followed diffusion transport. Results of one way ANOVA confirmed that there is no statistically significant difference (p > 0.05) between drug...
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Posted by admin on Aug 31, 2017 in |
Antibacterial proteins are evolutionarily ancient, effect or molecules of innate immune defense and are ubiquitously found in all kingdoms. The present study deals with the induction of antibacterial proteins in the haemolymph of Anthereae mylitta drury (Daba TV) by injecting non-pathogenic Pseudomonas DAS-01. Purified protein fraction obtained on ammonium sulphate precipitation followed by ion exchange chromatography had shown antibacterial activity against Pseudomonas aeruginosa AC-3 and Pseudomonas DAS – 01. Flow through obtained in ion exchange chromatography found effective in inhibiting the growth of both P. aeruginosa AC-3 and Pseudomonas DAS – 01. In induced larvae, purified antibacterial peptides obtained by ion exchange chromatography on SDS-PAGE had shown a molecular weight of 16kDa and 24kDa which have antibacterial activity and were not observed in...
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Posted by admin on Aug 31, 2017 in |
Norfloxacin is one of the 4-quinolone antibacterials and have many applications in veterinary and human medicine. It is extensively used antibiotic among fluoroquinolone antibiotics in both human and animal welfare. Therefore, the estimation and monitoring of norfloxacin in pharmaceutical preparations and effluents has become a topic of interest for researchers and industries. Existing methods require much time, expenses and sophisticated laboratory facilities. Most of the methods suggest the simultaneous determination of the drug along with the similar groups. There is a thirst among researchers for the development of simple, specific, sensitive and reliable methods suitable for routine laboratory facilities. Most of the methods are based on association of the drug either with metal complexes or reaction with pigments. The main objective of this paper is to review various existing methods for spectrophotometric determination of norfloxacin in order to explore the possibilities to overcome their drawbacks to develop new methods with enhanced simplicity, sensitivity, reproducibility,...
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