Posted by admin on Oct 31, 2025 in |
Migraine treatment efficacy is often limited by conventional oral delivery systems. The objective of this study was to formulate and optimize a thermoreversible in-situ nasal gel of Rimegepant to provide extended drug release and improve therapeutic effectiveness. Rimegepant-loaded thermoreversible in-situ nasal gels were formulated using varying concentrations of Poloxamer 407 and Gellan Gum through factorial design. Formulations were characterized for physicochemical properties, thermal behavior (DSC), drug-excipient compatibility (FTIR), gelation characteristics, mucoadhesive strength, and ex-vivo permeation using goat nasal mucosa. The optimized formulation (KF8) exhibited ideal characteristics with gelation temperature of 35.23±0.45°C, gelation time of 9.76±1.4 seconds, viscosity of 51.76±0.96 m.Pa. s, and mucoadhesive strength of 6972.2±19.39 dyne/cm². DSC analysis confirmed drug purity (melting point 175.53°C) and compatibility with excipients. Ex- vivo studies demonstrated sustained drug release with 98.31±4.92% permeation over 10 hours, flux of 12.51 µg/cm²/h, and permeability coefficient of 0.00167 cm/h. The developed thermoreversible in-situ nasal gel demonstrates promising potential for efficient Rimegepant delivery, combining optimal gelation characteristics, sustained release, and warranting further clinical investigation for migraine...
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Posted by admin on Oct 31, 2025 in |
Ceiba pentandra is a plant in the African pharmacopoeia known for its antihypertensive properties. The aim of this study was to evaluate the antihypertensive effects of an aqueous extract of leaves of Ceiba pentandra (AECp) in Wistar rats. To do this, rats made hypertensive, by subcutaneous injection of Deoxycorticosterone acetate (DOCA) dosed at 25 mg/kg of body weight (BW) associated with a 1% sodium chloride (NaCl) drink for three weeks, were used to determine systolic blood pressure (SBP), diastolic blood pressure (DBP) and respiratory rate (RR) using a Contec 08A-VET type sphygmomanometer. Treatment of hypertensive rats for three weeks with AECp at 1000 mg/kg B.P. and Nifedipine, Captopril and Propranolol, all at 20 mg/kg B.P., promoted a highly significant (P ≤ 0.001) reduction in PAS, DBP and RF of hypertensive rats. Analysis of biochemical markers revealed that AECp improved highly significantly (P ≤ 0.001) the levels of creatine kinase (CK-MB), aspartate amino transferase (AST), alamine amino transferase (ALT), triglycerides (TG) and total cholesterol in hypertensive rats. AECp also reduced...
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Posted by admin on Oct 31, 2025 in |
Quality by Design (QbD) is a systematic approach in pharmaceutical development that focuses on predefined objectives, scientific understanding and quality risk management. It involves defining a Quality Target Product Profile (QTPP), identifying Critical Quality Attributes (CQAs), Critical Material Attributes (CMAs) and Critical Process Parameters (CPPs). It is implemented for control strategies to ensure product quality, safety and efficacy by using tools such as risk assessment, Design of Experiments (DoE), Process Analytical Technology (PAT) and Ishikawa diagrams support QbD throughout the product lifecycle. Simultaneously, Nanotechnology has revolutionized drug delivery by improving solubility, bioavailability and targeted delivery. Nano-pharmaceuticals like liposomes, polymeric nanoparticles and nanosuspensions benefit greatly from QbD principles. Integrating QbD into nano-drug development enables better control of particle size, zeta potential, drug loading, and release kinetics, which are critical for performance and safety. Computational tools and design optimization techniques further streamline this development. The integration of QbD and nanotechnology enhances the reliability, effectiveness, and regulatory compliance of advanced drug products. This synergy not only accelerates innovation and improves therapeutic outcomes...
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Posted by admin on Oct 31, 2025 in |
Dermatological disorders are among the most common ailments seen in outpatient departments in India. Rational prescribing plays a critical role in ensuring safe and cost-effective therapy for such patients. This prospective observational study was conducted to analyse the prescribing patterns in the dermatology outpatient department of a tertiary care hospital over a six-month period. A total of 210 prescriptions were evaluated based on demographic profile, common dermatological conditions, categories of drugs prescribed, route of administration, and adverse drug reactions. The majority of patients were aged between 30–39 years, with a male predominance. Tinea corporis was the most prevalent condition. Antihistamines and antifungals were the most commonly prescribed drug categories, while oral tablets were the most frequently used dosage form. Corticosteroids were prescribed in 49% of the cases. Adverse drug reactions were reported in 27% of patients, primarily presenting as itching and burning. This study highlights the importance of regular prescribing audits to ensure evidence-based and rational use of dermatological...
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Posted by admin on Sep 30, 2025 in |
Cardiac electrophysiology has undergone significant advancements in recent decades, revolutionizing the diagnosis and treatment of heart rhythm disorders. This narrative review explores the integration of diagnostic and therapeutic approaches in modern arrhythmia management. We discuss the evolution of electrophysiology studies, highlighting their crucial role in guiding ablation procedures and treatment planning. The review examines radiofrequency ablation techniques, their mechanisms of action, and outcomes across various arrhythmia types. We also explore the progress in pacemaker technology, from traditional devices to leadless and physiological pacing systems. The synergistic use of these technologies in clinical practice is emphasized, demonstrating how their integration enhances patient care. We analyze patient outcomes, comparing the effectiveness of medical and interventional approaches, and discuss long-term safety and efficacy data. The review addresses special considerations for pediatric and elderly populations, as well as patients with comorbidities. Cost-effectiveness and resource utilization in electrophysiology procedures are also examined. Looking to the future, we highlight emerging technologies and approaches, including advanced mapping systems, novel energy sources for ablation, and the potential...
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