Posted by admin on Jun 30, 2025 in |
Chromatography is a separation process that is achieved by distributing the substances to be separated between a moving phase and a stationary phase. HPLC is high resolution, high pressure and high-speed liquid chromatography. It has several resolving powers than open column liquid chromatography hence it is used for speedy resolution of complex mixture, separation and determination of species in a variety of organic, inorganic and biological materials. The developed HPLC method was validated for various parameters like accuracy, precision, specificity, LOD, LOQ, linearity, range and robustness as per ICH guidelines. The results obtained were well within the acceptance criteria for all the parameters. The proposed method was applied for simultaneous estimation of Tamsulosin and Dutasteride formulation. The HPLC system used was WATERS Alliance series System with Rheodyne injector 20 μL and the column Inertsil ODS 250 x 4.6 mm, 5 μm. The mobile phase comprised of Sodium phosphate buffer and Acetonitrile in the ratio of 30:70 v/v and flow rate of 1.0 ml/min with UV detection at 233 nm...
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Posted by admin on Jun 30, 2025 in |
Smart drug delivery systems are a key innovation in pharmaceutical technology that aims to enhance the efficacy and safety of therapeutic interventions. These systems integrate advanced materials, microelectronics, and responsive mechanisms to deliver drugs in a controlled, targeted, and adaptive manner. The development of smart drug delivery systems is driven by the need to improve patient compliance, minimize side effects, and optimize therapeutic outcomes. These cutting-edge delivery systems utilize various medication carriers, including nanoparticle systems such as inorganic nanoparticles (e.g., magnetic nanoparticles and quantum dots), monoclonal antibodies, microspheres, dendrimers, liposomes, and lipoproteins. The potential of smart drug delivery systems to revolutionize personalized medicine and improve treatment paradigms is critically analyzed. This paper reviews recent innovations in smart drug delivery, highlighting key technologies such as nanoparticle-based carriers, polymeric systems, and stimuli-responsive delivery platform. Emphasis is placed on the mechanisms of drug release, such as pH-sensitive, temperature-sensitive, and biologically triggered systems. Additionally, the integration of real-time monitoring and feedback mechanisms is explored, illustrating how these systems can adjust drug release rates...
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Posted by admin on May 31, 2025 in |
In recent days some groups are seeking infertility treatment, on the other hand there are groups seeking contraception methods. Nowadays there are several ways are available for contraception such are Oral contraceptive pills, implants, injectable, patches, rings, intra uterine devices, Male and Female sterilization and so on. WHO stated that the number of women desiring to use family planning has increased markedly over the past two decades from 900 million in year 2000 and 1.1 billion in the year 2021. Between 2000 to 2020 the contraceptive prevalence rate increased from 47.7 to 49%. WHO assists countries to adapt and implement contraception tools to strengthen contraceptive policies and programs. Siddhars, who were the founders of Siddha Medicine. From their insights they told lot of medicines for all health ailments. Even for disease prevention, diagnosis and to cure the disease. Siddha literature evidenced that the natural contraception method by using herbal drugs which would be effective. Poovarasan (Thespesia populnea) tree bark, Induppu (Rock or pink salt) and Kaaichukatti (Acacia catechu) taken...
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Posted by admin on May 31, 2025 in |
Medicinal plants are of great importance to researchers in the field of pharmacology as most pharmaceutical industries depend on medicinal plant for their raw materials. Meyna laxiflora belongs to the family Rubaceae and is well known for its medicinal properties. The present study was carried out in continuation of our previous findings to determine the possible bioactive components present in the aqueous and methanolic extracts of Meyna laxiflora fruit pulp. The gas chromatography – Mass spectrometry was used for identification of the bioactive compounds in the extracts and the spectrums of unknown compounds were compared with the compounds stored in the National Institute of Standards and Technology Mass Spectral database (NIST). The GC-MS analysis revealed the presence of 37 peaks in aqueous extract among these 19 were found to be major compounds while that of methanolic extract showed 24 peaks of which 15 were found to be major compounds. Hence, the present study has generated baseline data for further characterization of fruit pulp extract of this...
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Posted by admin on May 31, 2025 in |
Momordica cymbalaria, an underexplored vegetable crop native to India, holds significant therapeutic potential due to its traditional antidiabetic use. This study explores its phylogenetic characterization, protein structure modelling, and phytochemical profiling, emphasizing its role in diabetes management. The 5.8S rRNA internal transcribed spacer sequence was retrieved from NCBI and analysed using BLAST, identifying 17 related species and insights into its evolutionary positioning. Phylogenetic analysis revealed close relationships with Momordi cafoetida and distant similarity to Momordica balsamina. Protein structure prediction using SWISS-MODEL and PyMOL identified key structural features and active sites. Three open reading frames (ORFs) were identified, potentially encoding proteins involved in diabetes-related pathways. Phytochemical analysis using Dr. Duke’s and IMPPAT databases highlighted bioactive compounds such as beta-sitosterol, ergosterol, and alpha-eleostearic acid (ESA), a potent antidiabetic compound. ESA modulates the adipose deposition pathway and improves glucose regulation by interacting with proteins like peroxisome proliferator-activated receptor gamma (PPARG) and ribosomal protein L19. In-silico analysis demonstrated ESA’s ability to enhance GLUT-4 and beta-glucokinase activity, facilitating glucose uptake and improving metabolic efficiency....
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