Posted by admin on Jun 30, 2025 in |
A new method in this field called film-forming gels may offer an alternative to the common skin dosage forms such ointments, creams, gels, or patches. When applied as a liquid, the polymeric solution evaporates to create a nearly undetectable layer on the skin. Dermal medication delivery and transdermal drug delivery systems compared to traditional pharmaceutical dosage formulations, the approach can offer certain desirable performance, for eliminating first-pass metabolism in the stomach and liver, increasing medication bioavailability, lowering dosage frequency, and stabilizing drug delivery overview. The purpose of this review was to find alternatives to traditional forms that would decrease skin irritation, boost patient acceptability from a cosmetic standpoint, improve skin adhesion qualities, and enhance drug release. The unique rheological nature of polymeric gels makes them advantageous in terms of preparation simplicity. Application simplicity, adherence to the application surface, and broad drug delivery...
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Posted by admin on Jun 30, 2025 in |
Background: Hepatic Encephalopathy (HE) is a condition that is generally seen in individuals suffering from liver cirrhosis. HE is described as a range of neuropsychiatric diseases in individuals with liver diseases. It is characterized by personality changes, intellectual impairment and a depressed consciousness. Toxic substances that are generally excluded from the body by the liver accumulate in the blood and ultimately reach the brain, causing HE. Incidence rate of HE is estimated by various authors at about 30-84% of cases with liver cirrhosis depending on the applied diagnostic methods and examined population. Ammonia is one of the major neurotoxins produced in HE. Various triggers of HE includes renal failure, GI bleeding, constipation, infection, alcohol consumption, etc. Typically, bacteria within the gastrointestinal tract generate ammonia, which is then processed and eliminated by the liver through metabolism. But in HE there is either a drop in the number of the performing hepatocytes, portosystemic shunting or both, resulting in dropped ammonia clearance and hyperammonaemia. Once ammonia crosses BBB, it has multiple neurotoxic...
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Posted by admin on Jun 30, 2025 in |
Post-traumatic stress disorder (PTSD) affects a significant portion of the global population and can lead to chronic psychiatric complications and other secondary health issues. Among these, cardiovascular disease (CVD) stands out prominently. The relationship between PTSD and CVD is complex and bidirectional, with PTSD increasing the risk of developing CVD and worsening its prognosis. This review explores the physiological, psychological, and behavioral pathways through which PTSD influences cardiovascular health, including dysregulation of the autonomic nervous system, chronic inflammation, and endothelial dysfunction. These mechanisms highlight the profound impact of PTSD on cardiovascular risk factors such as hypertension, dyslipidemia, and metabolic syndrome. Effective management strategies necessitate integrated approaches that address both PTSD symptoms and cardiovascular risk factors, emphasizing early intervention, lifestyle modifications, and psychological therapies. Understanding and managing the PTSD-CVD link is crucial for optimizing care and improving outcomes in affected...
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Posted by admin on Jun 30, 2025 in |
The objectives of the present study were to formulate facial powder cleansers using colored clays, green clay or red clay, as main ingredients and to investigate the foaming and cleansing properties of the powder cleansers. For foaming and cleansing purposes, natural foaming tea and synthetic sodium cocoyl isethionate (SCI), were employed. Eight formulations were prepared by varying types and amounts of colored clays (58.5% and 68.5% w/w) as well as surfactants (10% and 20% w/w). The formulations F1 to F4 contained red clay whereas F5 to F8 contained green clay. Then, appearances, pH values, foaming and cleansing abilities of the formulations were investigated. The stability of the cleansers was also evaluated by keeping the preparations at ambient temperature and 45 °C for 60 days. Small differences in color shades of facial cleansers were detected using a spectrophotometer and CIELAB color system. The prepared cleansers had weak acidic pH (pH 5.7 to pH 6.5). The formulations with synthetic SCI had superior foaming property to those with foaming tea (p <...
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Posted by admin on Jun 30, 2025 in |
Background: Tuberculosis is a great menace to mankind since ancient times. The genus mycobacterium was known to originate 150 million years ago. Despite the discovery of many newer methods in the diagnosis of tuberculosis, a robust point of care test is required for effective management of Paediatric tuberculosis. Methodology: We conducted this study in paediatrics department of N.M.C.H for 1 year. After obtaining written informed consent, we enrolled cases in our study. All cases were subjected for focussed history from Guardians. Gastric Aspirate, Sputum, Induced Sputum, Ascitic fluid, CSF were collected is a wide mouthed container for sputum microscopy & in Falcons tube for CBNAAT. The microscopic examination of the samples were done by LED microscope using Z-N staining Technique. Results: Out of 51 samples analysed by microscopy and CBNAAT, CBNAAT has higher positivity rate (17.6%) than microscopy technique (5.8%). Result analysed using chi square test, considering CBNAAT as gold standard. The resulting value (p=0.027) interprets that the p value is less than 0.05. It is statistically significant. Conclusion:...
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