Posted by admin on Jun 30, 2025 in |
Background: Seizure occurs more frequently in neonatal period than in any other time of life. Estimated incidence of neonatal seizure varies according to case definition, method of ascertainment and definition of the neonatal period and ranges from 1 to 5 per 1000 live births. Methodology: Neonates admitted in Nicu, department of Paediatrics, Nalanda Medical College and Hospital, Patna in time period of Aug 2023- July 2024. Sample size was 100. For seizure control in neonates with active convulsion either levetiracetam or phenobarbitone was allocated to the randomization. Intravenous levetiracetam is given at a loading dose of 20 mg/kg. Maintenance is given at a dose of 10mg/kg 8 hourly. Intravenous phenobarbitone is given at a dose of 20mg/kg and 5mg/kg 12hrly of maintenance dose. Results: In levetiracetam Group, 23(46.0%) patients had1number of loading dose required, 14(28.0%) patients had 2 number of loading dose required and 13(26.0%) patient had 3number of loading dose required. In phenobarbitone Group, 28(56.0%) patients had 1number of loading dose required, 9(18.0%) patients had 2 number of...
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Posted by admin on Jun 30, 2025 in |
Background: Allergic Fungal Rhinosinusitis (AFRS) is a common disease and denoted as Chronic Rhinosinusitis with polyps (CRSwNP). Presents as Eosinophilic nasal polyps, and allergic mucin in the nose and sinuses demonstrable with Functional Endoscopic sinus surgery (FESS) surgery. The biological markers predicting this disease entity are uncertain. Physicians experience difficult to predict the outcomes of various methods of treatment adopted to treat AFRS. Sometimes involvements of blood inflammatory cells were used to predict the recovery of the disease and its prognosis. Aim of the Study: To study the levels of pre-operative blood Eosinophils and Basophils in patients with AFRS and compare them postoperatively in terms of recurrence of polypi and allergic symptoms. Materials and Methods: 69 adult patients diagnosed with AFRS at the tertiary teaching Hospital in Andhra Pradesh were included. Patients were treated with FESS for AFRS. The final outcomes were assessed on the basis of blood Eosinophils and Basophils and correlating with the recurrence of symptoms and polypi. Results: Recurrence of polypi in 14 of 69 patients with overall...
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Posted by admin on Jun 30, 2025 in |
Herbal tea has emerged as a key component in the development of functional foods, offering a wide range of health benefits and applications. This comprehensive review explores the role of herbal teas in promoting health and wellness, focusing on their rich content of bioactive compounds such as polyphenols, flavonoids, and antioxidants. These compounds contribute to various health-promoting properties, including anti-inflammatory, antimicrobial, and immune-boosting effects. The incorporation of herbal teas in functional foods enhances their nutritional value and provides therapeutic potential in managing chronic conditions like cardiovascular disease, diabetes, and digestive disorders. Additionally, herbal teas are applied in diverse food products, such as beverages, baked goods, and dietary supplements, where their flavor, aroma, and health-promoting properties are utilized. This review highlights the growing interest in herbal teas as functional ingredients and their promising role in improving overall well-being through dietary innovation. The review also addresses key considerations such as safety measures, quality control, and regulatory frameworks to ensure the effective use of herbal teas in functional food products. Additionally, it...
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Posted by admin on Jun 30, 2025 in |
The study investigates the anti-implantation and early abortifacient effects of Luffa acutangula fruit, traditionally claimed by tribals in the Pandharkawada region of Maharashtra, on female albino rats. To evaluate its efficacy, fertile male and female albino rats were paired, and the females were divided into 13 groups, including a control group receiving distilled water and 12 experimental groups administered varying doses (100, 200, 400 mg/kg body weight) of L. acutangula extracts for 1-7 days. On the 10th day of gestation, laparotomy was performed to assess implantation sites and corpora lutea counts. Phytochemical analysis revealed the presence of several bioactive compounds, including alkaloids, flavonoids, and steroids, while no toxicity symptoms were observed in the treated animals. Results indicated significant post-coital antifertility activity, with a reduction in implantation rates ranging from 12.61% to 72% across different extracts. Notably, the chloroform and ethyl acetate extracts yielded higher litter sizes compared to the control group. However, other reproductive metrics, such as litter body weight, total body length, gestation period, and sex ratios, did...
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Posted by admin on Jun 30, 2025 in |
Hypertension is a ubiquitous and serious worldwide health concern, having a dramatic influence on individual health outcomes. In light of this rising worry, Azelnidipine, a third generation long-acting dihydropyridine calcium channel blocker, has emerged as a prospective therapeutic treatment. A vast body of research has indicated that Azelnidipine produces a strong antihypertensive impact, especially in individuals diagnosed with essential hypertension, thus validating its therapeutic usefulness in controlling this prevalent illness. This thorough study strives to give an in-depth overview of the numerous analytical techniques applied for the measurement of Azelnidipine. It covers a variety of techniques, including spectroscopic UV analysis, as well as chromatographic methods such as reversed-phase high-performance liquid chromatography (RP-HPLC), high-performance thin-layer chromatography (HPTLC), and ultra-performance liquid chromatography (UPLC), either alone or in combination with other drugs. These methodologies together give useful insights into the reliable measurement of Azelnidipine in pharmaceutical formulations. These techniques are tested for accuracy, precision, and resilience according to ICH criteria. They are excellent for both bulk medication and tablet dose forms because...
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