Posted by admin on Apr 30, 2025 in |
This review paper provides a comprehensive overview of the role of machine learning (ML) in drug discovery and development within the pharmaceutical industry. It begins by outlining the foundational concepts of machine learning, highlighting its ability to enhance decision-making and improve accuracy through data analysis. The paper emphasizes the growing adoption of ML techniques across the pharmaceutical sector, showcasing their potential to streamline drug discovery processes, reduce costs, and minimize reliance on animal testing. It categorizes various machine learning methods, such as supervised, unsupervised, semi-supervised, and reinforcement learning, and discusses their applications in drug discovery, including predicting drug efficacy, optimizing lead compounds, and validating safety biomarkers. Furthermore, the paper delves into advanced ML techniques like transfer learning, multitask learning, and active learning, which address challenges related to data scarcity and enhance model performance. The discussion also covers specific algorithms such as Support Vector Machines, Decision Trees, and Artificial Neural Networks, illustrating their utility in predicting biological properties and improving drug design. Ultimately, the paper concludes that the integration of...
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Posted by admin on Apr 30, 2025 in |
The kidney is an important organ in waste filtration, plays a central role in maintaining body homeostasis. The management of kidney stones includes several techniques over the period of time which involve Percutaneous Nephrolithotomy (PCNL), Shock wave lithotripsy (SWL) and Ureteroscopy (URS). Ureteroscopy has undergone considerable innovations over the last few decades. Laser technologies have further advancement for kidney stone removal that is Holmium fiber laser technique and thulium fiber laser technique. Holmium laser technique removes the stone by dusting and fragmenting it. The selection of technique depends on stone type, size and location. Thulium fiber laser has higher precision and efficiency due to its shorter wavelengths and continuous-wave emission characteristic. These technological advancements have resulted in more positive patient outcomes due to reduction in recovery times and fewer complications. This review provides complete overview of the physiology of the kidney, composition of kidney stone, factors affecting on their formation and the management techniques with focusing on the development of ureteroscopy and the latest laser technologies for kidney stone...
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Posted by admin on Apr 30, 2025 in |
Objective: Sunitinib malate is an oral, potent multi-targeted TKI that displays antitumor and anti-angiogenic actions. The core focus of the present research work is to establish an innovative QbD-based analytical method for the estimation of Sunitinib malate in solid dosage form by ultra-high performance liquid chromatography (UHPLC). Materials and Methods: The change in independent variables, wavelength, flow rate and Acetonitrile concentration with response to retention time, area and tailing factor were studied using Box-Behnken design. Chromatographic separation was accomplished by using XBridge shield RP18 (50mm x 3mm, 2.5μm) column, flow rate was adjusted to 0.7mL/min. at a temperature of 25ºC. The detection was carried out at 388nm with a run time of 5 min. Results and Discussion: The retention time of Sunitinib malate was found to be 2.391 min. The method is robust, accurate and precise, as depicted by the statistical data of analysis. The correlation coefficient was found to be 0.999. The solution was found to be stable for 24 hours at 250C. Hence the current research work...
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Posted by admin on Apr 30, 2025 in |
This study investigated the efficacy and safety of three herbal decoctions for managing Polycystic Ovary Syndrome (PCOS), a condition affecting 2–26% of women globally and considered incurable within allopathic medicine and offers symptomatic treatments. This randomized, single-blind clinical trial, conducted between February 2022 and June 2024, enrolled 90 PCOS patients diagnosed by the Rotterdam (2003) criteria. Participants were randomly allocated into three intervention groups: Nigella sativa (Arm I), Sesamum indicum (Arm II), and a combination of both (Arm III). Each group received 30 ml of the assigned decoction twice daily over three months. Clinical parameters were assessed using established grading scales, including androgenic alopecia, hirsutism, acne, and acanthosis nigricans. Additionally, ultrasound scans (USS) were performed pre- and post-treatment to evaluate changes in ovarian morphology. Results indicated a significant reduction in ovarian volume for Arms I (P=0.029) and II (P=0.008) and an increase in follicle size across all three arms. The number of participants with polycystic ovarian morphology significantly decreased in Arm I (P=0.016) and II (P=0.004). However, one-way ANOVA...
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Posted by admin on Apr 30, 2025 in |
Background & Objective: India is home to two infectious diseases caused by Salmonella: typhoid and paratyphoid fever. The medication of choice for S. typhi is ceftriaxone, a third-generation cephalosporin. Study was carried out on the Surveillance of Enteric Fever in India to ascertain the prevalence, clinical manifestation, and trajectory of antimicrobial resistance (AMR). This work aimed to examine the antibiogram profiles of Salmonella typhi found in patient blood cultures. Second, to record how often Salmonella typhi infections occur located in Vadodara, the Antibiotic Susceptibility Test is third. Material and Methods: The Retrospective study was carried out over a period of 12 months after obtaining ethical approval. The freshly drawn venous blood was placed in a blood culture vial. Following identification of pathogen isolates, Kirby-Bauer disc diffusion test was employed to determine antibiotic drug susceptibility as per CLSI rules. Results: Total 10,126 blood samples were collected. In 84 samples (0.83%), 83 instances of Salmonella typhi and 1 instance of Para typhi B. The ratio of males to females was 1:2....
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