Posted by admin on Mar 31, 2025 in |
The utility of herbal medicines incresed for curative purposes in the past few years. They serve as a curative alternative for a significant section of the worldwide community. Nonetheless, assessing the reliability of such facilities continues to be challenging in guaranteeing their safe use. Acute and subacute toxicity studies were conducted in a rat model. The cytotoxicity assay and AO/PI staining of HALEPR was carried out in an endometrial cell. Acute toxicity was evaluated in female Charles Foster rats over 14 days, revealing no mortality or severe adverse effects, suggesting a Lethal Dose 50 (LD50) above 2000 mg/kg. Subacute toxicity was assessed over 28 days with no significant changes (P < 0.05) in body weight, feed consumption, water intake, or biochemical parameters. Histological examination of organ tissues indicated no notable differences between treated and control groups. The antiproliferative activity of HALEPR was investigated using primary endometrial cell cultures. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay demonstrated a significant apoptotic effect with an IC50 of 41.46 µg/mL. This result was further confirmed...
Read More
Posted by admin on Mar 31, 2025 in |
Diabetes mellitus is a chronic metabolic disorder characterized by high levels of glucose in blood due to non-secretion of insulin or insulin insensitivity. Diabetes mellitus can cause many complications, acute complications include non ketotic hyperosmolar coma and diabetic ketoacidosis. Different types of diabetes mellitus are available – Type 1 diabetes mellitus (hormone dependent diabetes) and Type 2 diabetes mellitus (non-insulin dependent polygenic disorder mellitus) are now recognized as serious global health problem, growing rapidly worldwide and taking its place one of the main theats to human health in the 21st century. In diabetes history gestational diabetes is the major and big problem, approximately 5 to 10 percent all pregnant women in the India is diagnosed as having gestational diabetes. The main indication of diabetes mellitus is a hyperglycemia in blood which due to in appropriate pancreatic insulin secretion or low insulin directed fostering to glucose by target cells. It is silent and affects millions of people in the world. It is estimated that in 2010 there was globally 300...
Read More
Posted by admin on Mar 31, 2025 in |
Background: This study presents the extraction, fractionation, formulation, and evaluation of transdermal polyherbal films containing Curcumin and Capsaicin for potential anti-inflammatory use. Capsicum annuum extract underwent ethanol-based extraction and fractionation, isolating alkaloids for further study. Results: Phytochemical screening revealed the presence of alkaloids, flavonoids, polyphenols, and terpenoids in both Curcuma longa and Capsicum annuum extracts. Chemical fractionation was done for Capsicum annuum extract, Dichloromethane fraction given the best results for alkaloids. Compatibility studies employing FTIR and DSC demonstrated the compatibility of Curcumin and Capsaicin with excipients, crucial for film formulation. In-silico molecular docking studies elucidated interactions between Capsaicin/Curcumin and Cox-2 protein, hinting at potential anti-inflammatory activity. The films were formulated using chitosan and solid dispersions of Curcuminoids/Capsaicinoids with Eudragit® EPO. Evaluation encompassed various parameters like weight variation, thickness, folding endurance, moisture content, water uptake, drug content, and in-vitro drug release. Further assessment involved a Carrageenan-induced paw edema model in rats, comparing different film formulations with a standard Diclofenac patch for their anti-inflammatory efficacy. Conclusion: This comprehensive approach involving extraction,...
Read More
Posted by admin on Mar 31, 2025 in |
Rheumatoid arthritis (RA) is a chronic inflammation disorder that primarily affects the joints and leads to the progressive destruction of joints, synovial hyperplasia bone, and cartilage degeneration. Globally 1% of the world population was affected by rheumatoid arthritis. The present study focused to identify the bioactive phytocompounds of polyherbal formulation- Erandadi Kwatham and to determine its potential in inhibiting the targets TNF-α and Hk-II, which are associated with rheumatoid arthritis. The 3D structure of the phytocompounds were retrieved and analyzed for its physicochemical properties, toxicity, and drug-likeness were determined using the Qikprop module in maestro Schrodinger software. Among, only six compounds satisfied the ADME properties and followed drug-likeness. Further the phytocompounds triethyl citrate (6506), butanedioic acid, hydroxyl diethyl ester (24197), L-Valine, ethyl ester (87182), phenylacetic acid (97942), 7-trihydroxy-1-methyl – 8 – methylene-1, 4a-lactone-10-methyl (539615), and pectolinarigenin (5320438), were analyzed using molecular docking studies against the protein targets, TNF-α and Hk-II. The compounds triethyl citrate and pectolinarigenin were observed with significant binding efficiency of -3.47 and -5.88 kcal/mol against the...
Read More
Posted by admin on Mar 31, 2025 in |
Psychogenic non-epileptic seizures (PNES), which intently look like epileptic seizures (ES), are regularly set off by mental trouble and address the most pervasive type of change issue experienced in clinical practice. Different states of being can both encourage and support PNES episodes. PNES episodes. Epilepsy, a common neurological disorder, imposes significant emotional and physical burdens, frequently resulting in elevated levels of anxiety and depression. This case report details the clinical course of a 25-year-old female diagnosed with PNES. The patient background of childhood trauma, early marriage, and depression likely predisposed her to the development of PNES upon diagnosing with epilepsy, characterized by seizure and depression, the patient experienced increased anxiety, irritability, loss of consciousness, and required hospitalization. Her treatment regimen of intravenous administration of Injection Levetiracetam 500 mg and oral olanzapine 2.5 mg to her seizures persisted. On evaluation of electroencephalography EEG and CT scan indicated the epilepsy and Panes. Although the surgical intervention was unnecessary, the management of epilepsy with ongoing pharmacotherapy significantly reduced her PNES episodes. This...
Read More
