Posted by admin on Mar 31, 2025 in |
The combination of bioinformatics and AI improves the precision and productivity of medication development. Artificial intelligence (AI)-powered tools such as AlphaFold and Atomwise speed up the discovery process, and natural language processing (NLP) helps with literature mining and medication repurposing. Advanced approaches such as automated drug testing and quantum computing are also being studied. Despite challenges such as legal constraints and data quality difficulties, the report emphasizes the potential for these technologies to alter precision medicine in the future. This review looks at how bioinformatics and artificial intelligence are altering the pharmaceutical sector. Especially for complex diseases such as neurodegenerative disorders, conventional drug development approaches are costly, time-consuming, and yield low-quality results. AI methods such as machine learning (ML) and deep learning (DL) significantly speed up drug discovery by predicting drug-target interactions, optimizing drug design, and analyzing ADMET profiles. Meanwhile, bioinformatics facilitates the understanding of biological data by means of the analysis of proteomic, metabolomic, and genomic data. This allows greater...
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Posted by admin on Mar 31, 2025 in |
This study aimed to design and evaluate a thermoreversible, mucoadhesive intranasal gel formulation of Trazodone HCl for enhanced drug delivery to the brain. Pre-formulation processes involved characterization of the drug using UV spectroscopy, FTIR, and DSC techniques to confirm drug purity and compatibility with excipients. The nasal gel was formulated using Poloxamer 407 (19%) and Carbopol 934P (0.1% – 0.5%) through the cold method. The formulated gels were evaluated for pH, clarity, viscosity, mucoadhesive strength, in-vitro drug release, and ex vivo permeation across goat nasal mucosa. Gelation temperature was optimized to align with physiological nasal temperatures (32–34°C), and results demonstrated effective sol-to-gel transitions. Drug release studies revealed over 85% release from optimized formulation (A4) within 8 hours. Ex-vivo permeation studies confirmed significant drug absorption through the nasal membrane, with A4 exhibiting 78.45% cumulative drug release. Stability studies validated the formulations’ reliability, and no incompatibilities were observed between drug and excipients. This intranasal gel formulation represents a promising, non-invasive approach to improve the bioavailability and therapeutic efficacy of Trazodone HCl...
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Posted by admin on Mar 31, 2025 in |
Eryngium foetidum commonly known as cilantro or spiny coriander is a tropical perennial herb known for its distinctive aroma and medicinal properties. While it is mainly used as a culinary herb, it has long been valued in traditional medicine for a variety of health benefits. The present study was intended to analyse the phytochemicals present in the ethanolic extract of the leaf. Qualitative analysis has revealed the presence of various bioactive compounds and the major classes of phytochemicals typically found in Eryngium foetidum were flavonoids, tri-terpenoids, steroids, tannin, saponin, carbohydrate and phenol. Also, attempt has been made to isolate endophytic bacteria from Eryngium foetidium after performing controlled surface sterilization. The isolated organisms were marked as B1 and B2 and subjected to perform antibacterial and antifungal activities against important pathogenic strains viz; Staphylococcus aureus, Pseudomonas aeroginosa, E. coli, Klebsiella pneumonia & Aspergillus sp. The B1 isolate was however found to be effective with its substantial activities with zone of inhibitions of 18mm, 17mm, 15mm and 17mm respectively along with the...
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Posted by admin on Mar 31, 2025 in |
Introduction: The use of supplements in the fitness industry has experienced a notable surge due to the growing awareness of their potential health benefits. Fat burners, a popular type of supplement, are commonly employed to assist in weight loss. However, it is important to acknowledge that fat burners can have adverse effects on the body. Common side effects include increased heart rate, elevated blood pressure, sleep disturbances, restlessness, heightened anxiety, and digestive issues. They often contain ingredients like green tea extract, herbs, and minerals, which can enhance energy levels and speed up metabolism. Some fat burners also include stimulants like caffeine, ephedrine, and yohimbine, which can lead to additional problems like rapid heart rate, dehydration, and agitation. In certain cases, fat burners may even pose a risk to liver health. Objective: To ensure the safety and accuracy of fat burner supplements, a method known as RP-HPLC (Reversed Phase High-Performance Liquid Chromatography) was developed and validated according to the guidelines established by ICH of Technical Requirements for Pharmaceuticals for Human...
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Posted by admin on Mar 31, 2025 in |
The aim of the present work was to develop clindamycin phosphate-loaded nanosuspension lyophilized powder for axillary osmidrosis caused by bacterial activity in apocrine glands. The formulation prepared using the solvent/antisolvent method included Eudragit L100, PVP K30, and Tween 80. Optimization via central-composite design (CCD) yielded formulation with a particle size of 179 nm and viscosity of 1.35 cps. Characterization confirmed favorable sedimentation volume, drug content and zeta potential with SEM revealing a spherical and porous structure. Lyophilization improved stability and permeability, and in-vitro studies demonstrated 24-hour drug release. Antibacterial testing showed good efficacy against Staphylococcus aureus indicating potential of clindamycin nanosuspension as a promising topical delivery system with enhanced...
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