Posted by admin on Mar 31, 2025 in |
Nanocrystals are crystalline particles having particle size range of 100 to 1000 nm. However, these nano-sized systems are thermodynamically unstable, stabilizers are required to incorporate them. The poorly soluble drugs lead to problems like poor absorption and therapeutic failure. One such method to overcome these solubility problems is the development of nanocrystals. These systems reduce particle size that increases surface area and hence dissolution. Nanoscience technology results in improving solubility, bioavailability and dissolution rate of poorly water-soluble drugs. According to the Noyes-Whitney equation, there is a direct relationship between dissolution rate and surface area of drug particles. Various methods of preparation nanocrystals are Crystallization method, Anti-solvent crystallization, High gravity-controlled precipitation. Evaluation of nanocrystals with different...
Read More
Posted by admin on Mar 31, 2025 in |
Postpartum hemorrhage (PPH) is one of the leading causes of maternal morbidity and mortality, ranking third after throm-boembolism and hypertensive disorders. The primary goal of this study was to determine the effectiveness of balloon tamponade in the prevention and treatment of postpartum hemorrhage. The principle of balloon tamponade is to apply direct pressure to the bleeding vessels of the placental area using the wall of an inflated balloon within the uterus. The basic study included both retrospective and prospective research. The retrospective study group (no balloon tamponade performed) consisted of 72 patients, of whom 34 delivered vaginally and 38 underwent cesarean section. The prospective study group (balloon tamponade performed) included 40 women (20 with vaginal deliveries and 20 with operative deliveries). The effectiveness of the treatment was assessed based on two criteria: the volume of blood loss and the number of hysterectomies performed. In our study, the effectiveness of balloon tamponade was found to be 95%, based on the complete cessation of bleeding and the reduction in the length...
Read More
Posted by admin on Mar 31, 2025 in |
Introduction: Adverse events following immunisation (AEFI) are frequently underreported in India for numerous reasons, ultimately impacting the country’s immunisation program. The current study evaluates the knowledge, attitudes, and reporting practices (KAP) on vaccine vigilance among physicians in our hospital. Objectives: To find out various causes of Under-reporting of adverse events subsequent immunisation. Materials & Methods: Using a standard questionnaire, 200 doctors were interviewed. Responses were documented and analysed. Doctors had 37.8% knowledge while 68.9% had a good attitude but had poor reporting practices 34.6%. Results: Lack of knowledge, difficulty in filling reporting form, time constraints were the common causes for the under-reporting. Conclusion: Enhancing the perspective of AEFI, adequate training, and proactive involvement in reporting by healthcare practitioners could strengthen the nation’s vaccine surveillance...
Read More
Posted by admin on Mar 31, 2025 in |
Candesartan Cilexetil (CC) traditional dosage form has poor bioavailability and quick first pass metabolism, which leads to rapid elimination of the drug from the system and reduced plasma drug concentration during early morning heart attack incidence. The primary purpose of the Candesartan Cilexetil chronotherapeutic formulation is to optimally release the medicine in greater amounts in the early morning hours (when it is most needed) and in lower amounts at night (when it is least needed). Because systolic and diastolic blood pressures increase fast in the early morning by at least 15 to 25 mmHg and peak late in the day, Candesartan Cilexetil was successfully developed as microsponges to enhance its solubility and bioavailability and delivered as the pulsatile release (Pulsincap dosage form) for delivering the drug after the lag time of 5-6 h for the chronomodulated release of the drug. Microsponges and Pulsincap were subjected to various formulation parameters like FTIR, DSC, encapsulation efficiency, SEM, in-vitro dissolution and kinetic study. F9 formulation was selected as best formulation as it...
Read More
Posted by admin on Mar 31, 2025 in |
Drugs taken by humans and animals find their way into rivers, lakes, and even drinking water and can have devastating effects on the environment. This review summarizes the research regarding pharmaceutical industry emissions and the health risks of pharmaceutical wastewater exposure.The present review is prepared by the extensive literature survey using different search engines like google.com, PubMed, SCOPUS, Medline, Ind Med, and the library of Galgotias University, Greater Noida. This review observed the consumption of medicinal products as one of the main sources of environmental contamination due to excretion (urine, feces) and improper disposal of unused or expired medicines (toilet, sink, litter). Some medicinal products, in particular anti-parasiticides, antimycotics, antibiotics, and estrogens, which can all have ecotoxicological effects, pose environmental risks in specific cases. The supervision of pharmaceutical waste poses a great challenge to policy planners, city administrators, medical personnel, and workers in the recycling industry. It is interdisciplinary, involving pharmacy, nursing, environment services, infection control, quality assurance, risk management, etc. According to the most recent data on water quality in...
Read More
