Posted by admin on Feb 1, 2013 in |
Granisetron hydrochloride is most commonly used as an antiemetic agent in treatment associated with cancer chemotherapy induced nausea and vomiting. If the dosage form is designed in sustain release it provide more advantage for the antiemetic therapy. The purpose of this research was to study mucoadhesive buccal patches of Granisetron hydrochloride using the bioadhesive polymers chitosan and sodium alginate. Patches containing chitosan in 1.5%w/v and sodium alginate 2%w/v had maximum percentage of in vitro drug release and ex vivo drug permeation upto 8 hr. The swelling index was proportional to chitosan and sodium alginate content. The surface pH of all patches was found to be satisfactory (7.0 ± 1.5), close to neutral pH; hence, buccal cavity irritation will not be a problem with these patches. The mechanism of drug release was found to be Higuchi (matrix). The formulation F6 was optimized based on good bioadhesive strength (326.96±0.99 N/M2) and sustained in vitro drug release (95.81% ± 3.21% for 8 hr), ex vivo permeation (96.59% ± 3.69% for 8 ...
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Posted by admin on Feb 1, 2013 in |
The present study evaluates the reactive oxygen species (ROS) scavenging and in vitro antioxidant activities of two species of Cleome, C. viscosa and C. burmanni. The antioxidant potential of the methanol extracts of species of Cleome was tested using different assays such as FRAP, DPPH, ABTS, hydroxyl, superoxide, nitric oxide, and hydrogen peroxide. The extracts gave positive results for all the assays and the radical scavenging ability was detected to be comparable to those of the corresponding standards. Quantitative estimation of antioxidant phytochemicals, such as phenols, flavonoids and proanthocyanidins were also done in both species of Cleome. The results revealed that the phytochemicals content was greater in C. viscosa when compared to C....
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Posted by admin on Feb 1, 2013 in |
Fatty acid composition of six different leafy vegetables of Bangladesh was investigated. The amount of bound fatty acids was found to be higher than the free fatty acids in all the leafy vegetables. Different fatty acids were identified and their relative proportions were determined by GLC from the leafy vegetables....
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Posted by admin on Feb 1, 2013 in |
Hypertension is a chronic increase in blood pressure, characterized as primary and secondary hypertension. The disorder is associated with various risk factors like obesity, diabetes, age, lack of exercise etc. Hypertension is being treated since ancient times by Ayurvedic, Chinese and Unani medicine. Now various allopathic drugs are available which include diuretics, calcium channel blockers, α-blockers, β-blockers, vasodilators, central sympatholytics and ACE-inhibitors. Non-pharmacological treatments include weight reduction, dietary sodium reduction, increased potassium intake and reduction in alcohol consumption. ACE-inhibitors are widely used in the treatment of hypertension by inhibiting the angiotensin converting enzyme responsible for the conversion of angiotensin I to angiotensin II (responsible for vasoconstriction). Various structure activity relationship studies led to the synthesis of ACE-inhibitors, some are under clinical development. This comprehensive review gives various guidelines on classification of hypertension, hypertension therapy including ancient, pharmacological, non-pharmacological therapies, pharmacoeconomics, historical perspectives of ACE, renin, renin angiotensin system (circulating vs local RAS), mechanism of ACE inhibitors, and development of ACE inhibitors. Review also emphasizes on the recent advancements on...
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Posted by admin on Feb 1, 2013 in |
The purpose of the present research work was to develop ophthalmic sol to gel controlled delivery system of brimonidine, for the treatment of bacterial conjunctivitis having improved patient compliance and better therapeutic efficacy. For that purpose various formulations were prepared and evaluated for their quality parameters i.e. rheological, trans-corneal permeation, ocular irritation studies, microbiological study. The in-vitro release was determined by using modified flow through cell apparatus. The formulation X4Y2D shows very good result regarding to all quality parameters as well as shown sustained and satisfactory release over a period of 12...
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