Posted by admin on Mar 1, 2013 in |
Time dependent density functional theory (TDDFT) calculations have been carried out to study the electronic structure and the UV absorption spectra of Triamterene. The UV spectra have been investigated with inclusion of solvent effect. The B3LYP functional with a 6-31G(d, p) basis sets have been used to compute absorption energies. The solvent effects have been described within the polarizable continuum model (PCM). The geometries are optimized using density functional theory (DFT) with B3LYP functional combined with 6-31G(d, p) basis sets. The vertical absorption energies both in gas phase and in polar solvents such as ethanol, methanol and water were computed. Red-shift of the absorption maximum in the polar solvents is discussed in terms of electrostatic interaction energy, oscillator strength and dipole...
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Posted by admin on Mar 1, 2013 in |
The focus of this exploratory study was to determine if community pharmacists order laboratory tests, why they order the tests, type of tests they order and what they do with the outcome of such tests. Self-administered pre-tested 34-item semi-structured questionnaires were used to carry out this study among superintendent pharmacists’ of registered pharmacy premises in two south-western states in Nigeria. Descriptive statistics (frequency and percentages), Mann-Whitney U and Kruskal-Wallis tests were used to appropriately summarize the data obtained. All the respondents who consented to take part had ordered laboratory tests for patients prior to this study. The types of invasive and non-invasive tests ordered, ranged from simple dipstick pregnancy test to more varied tests like: fasting blood glucose 24(36.9%), blood pressure measurement 58(89.2%), malaria parasite test 47(72.3%), full blood count 16(24.6%), widal reaction test 45(69.2%), urinalysis 10(15.4%) mantoux test 3(4.6%) and hepatitis B & C test 3(4.6%). Some of the perceived benefits derived from interpreting laboratory test results were patient trust and confidence in pharmacists 28(43.1%), job satisfaction and...
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Posted by admin on Mar 1, 2013 in |
A series of some new Isoxazoline derivatives derived from 3-(4’-dimethylamino-phenyl)-1-(2-hydroxyphenyl)-Propenone(chalcone) derivatives using hydroxylamine hydrochloride is reported. These newly synthesized compounds were screened for their antimicrobial potencies which reflect moderate to good activity against different strains of bacteria and fungi employed. The promising feature of this reaction is mild reaction condition and excellent yield with high purity of compounds synthesized. All the synthesized compounds were confirmed by IR, 1HNMR and...
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Posted by admin on Mar 1, 2013 in |
In this study, the antioxidant capacity during UV exposure has been investigated by using a laser-based trace gas detector for the detection of gaseous ethylene as an indicator for lipid peroxidation. Biocream was used as a control and ascorbic acid, butylated hydroxytoluene, phloroglucinol and hydroquinone were added as antioxidants in a mixing concentration of 2.5% (w/w). The experimental results show that there is a decrease in the number of ROS due to the presence of antioxidants, from which ascorbic acid is the most effective. The detection method offers a direct and on-line way to evaluate the capability of antioxidant in reducing the harmful effect of the UV...
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Posted by admin on Mar 1, 2013 in |
Evolution of an existing drug molecule from a conventional form to a novel delivery system can significantly improve its performance in terms of patient compliance, safety and efficacy. In the form of a Novel Drug Delivery System an existing drug molecule can get a new life. An appropriately designed Novel Drug Delivery System can be a major advance for solving the problems related towards the release of the drug at specific site with specific rate. The need for delivering drugs to patients efficiently and with fewer side effects has prompted pharmaceutical companies to engage in the development of new drug delivery system. This article covers the basic information regarding Novel Drug Delivery Systems and also different types of the...
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