Posted by admin on Mar 1, 2013 in |
The effectiveness of topical therapies is limited by minimal drug permeability through the nail plate. Nail permeability is however quite low and limits topical therapy to early/mild disease states such as onychomycosis (fungal infections of the nail). Current research on nail permeation that focuses on altering the nail plate barrier by means of chemical treatments, penetration enhancers as well as physical and mechanical methods is reviewed also the recent research into ungual drug delivery is reviewed, a new method of nail sampling is examined. Topical therapy is worth pursuing however, as local action is required in many nail disorders. Drug transport into the nail plate can be assisted by filing the nail plate before topical application of drug formulations as well as by the use of chemical enhancers. Finally limitations of current ungual drug permeability studies are briefly discussed and the factors, which affect drug uptake and permeation through the nail plate such as solute molecular size, hydrophilicity/hydrophobicity, charge, and the nature of the vehicle, are then discussed, and...
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Posted by admin on Mar 1, 2013 in |
Epilepsy is a common chronic neurological disorder that requires long-term or sometimes lifetime therapy. Anticonvulsant drugs are used in large quantities during long-term antiepileptic therapy and the treatment may be associated with various metabolic abnormalities in connective tissues, endocrine system and the liver. Recent evidence indicates that prolonged use of antiepileptic drugs (AEDs) particularly carbamazepine (CBZ), phenytoin (PHT) might modify some vascular risk factors; however, the influence of AED therapy on the development of atherosclerosis has been the subject of controversy and pretty unclear. Some epidemiological studies have reported a higher prevalence of ischemic vascular disease among epileptic patients on AEDs, while in other studies the mortality due to atherosclerosis-related cardiovascular disease in treated epileptics has been observed to be lower than in the general population. The etiology of atherosclerosis-related vascular diseases in epileptic patients has not been fully clarified. Atherosclerotic vascular alterations may start early in life, this review focuses on major atherogenic risk, including disordered lipid profiles, and increased lipoprotein (a) serum levels among epileptic...
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Posted by admin on Mar 1, 2013 in |
Tinospora cordifolia (Thunb.) Miers, (Guduchi) is an evergreen perennial climber. This deciduous and dioecious plant belongs to the family Menispermaceae. It is a plant of significant medicinal importance in the Indian system and designated as Rasayana. Its efficacy has been also recognized by the modern system of medicine. The whole plant is used medicinally however; the stem is approved for use in medicine. This is due to higher alkaloid content in the stems than in the leaves. This plant has been known to possess immunomodulatory, hypoglycaemic, antioxidant, anti-hyperglycaemic, antiallergic, anti-inflammatory, diabetes...
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Posted by admin on Mar 1, 2013 in |
Background: Leprosy is one of the infectious diseases of public health importance; it is the leading cause of permanent physical disability as aresult of nerve damage. Individuals with leprosy have emotional stress and anxiety, which may lead to both psychological and psychiatric co-morbidity. Objective: This study was conducted to estimate the prevalence of mental distress among leprosy patients attending ALERT Specialized, Addis Ababa, Ethiopia. Method: Institution based cross-sectional study was conducted from April 2011-June 2011. Alternate patients from the daily register of outpatients were interviewed for symptoms of mental distress using the Self Reporting Questionnaire (SRQ-20). This questionnaire was administered by two trained nurses. Data was analyzed using SPSS version 15. Odds ratio were calculated to see the association of dependent variable with each independent variable. P-value <0.05 were considered as statistically significant. Result: The prevalence of mental distress was found to be 30.9%.Physical disability was also associated with mental distress. This study showed that mental distress was significantly higher in patients with leprosy. Conclusion: This piece of study...
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Posted by admin on Mar 1, 2013 in |
Ofloxacin is an antibacterial agent used to treat infections. It is extremely bitter in taste and taste should be masked to formulate it in a palatable form. The purpose of present research work was to formulate tasteless complexes of ofloxacin with indion 204 ion exchange resin. The drug loading onto ion-exchange resin was optimized for mixing time, activation, effect of pH, mode of mixing, ratio of drug: resin and temperature. The resinate was evaluated for taste masking and in vitro drug release. DSC analysis study supported complex formation. ofloxacin- indion 204 complex of ratio 1:1.5 was developed into orodispersible tablet using different superdisintegrants with varying concentration and was evaluated for weight variation, hardness, friability, wetting time, water absorption ratio, content uniformity, disintegration time and dissolution and was found superior over conventional formulation. The F5 batch with disintegration time 19.33 Sec ±3.78 and dissolution within 45 minutes 89.642±2.20 was selected as optimized formulation. By an appropriate selection and combination of excipients, it was possible to obtain orodispersible and taste masked...
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