Posted by admin on Dec 25, 2014 in |
Hemidesmus indicus Linn. R. Br. is a twining shrub traditionally used for the treatment of various diseases and ailments in the rural area of Bangladesh. Different extracts (methanol, hexane, ethyl acetate, n-butanol and water) from the roots of this shrub tested for their antimicrobial, cytotoxicity and free radical scavenging activities. All extracts showed moderate free radical scavenging activity and SC50 values ranging from 24.98µg/mL to 93.14µg/mL, and sufficient potency for their brine shrimp lethality activity and IC50 values from 1.32µg/mL to 8.67µg/mL. The n-hexane extract showed significant antimicrobial activity against all tested organisms, with a zone inhibition ranging from 10 mm to 27 mm at the concentration of 400µg/disc. Bioassay guided fraction of the extracts has led to isolation of two triterpeniods, 3β-O-acetyl β-amyrin, lupeol 3- β -acetate and a phenolic compound, 2-hydroxy-4-methoxy benzaldehyde. The structures of the compounds were elucidated on the basis of spectroscopic methods as well as comparison with available data in the...
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Posted by admin on Dec 25, 2014 in |
Morinda Pubescens belonging to the family rubiaceae has been reported to posses many medicinal properties according to indigenous system of medicine. The search for biologically active compounds from natural sources has always been of great interest to researchers looking for new drugs useful in infectious disease. In the present study, the various extracts of Morinda Pubescens bark was tested for their antibacterial and antifungal activities against gram positive bacteria such as Staphylococcus aureus, Bacillus cereus, gram negative organisms such as Escherichia coli, Pseudomonas aeruginosa and fungi such as Candida albicans, Aspergillus niger respectively by cup plate method. All the extracts were effective against the tested microorganism which was comparable with standard antibiotics. The ethanolic extract showed highest zone of inhibition then other extracts tested. The zone of inhibition of the extracts of Morinda Pubescens indicating that the plant of Morinda Pubescens can fight these microorganism effectively due to the presence of phenol,triterpinoids and tannins it could be better alternative to the modern...
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Posted by admin on Dec 25, 2014 in |
Madhucalongifolia is an economically important medicinal tree growing throughout the subtropical region. This research article deals with the antioxidant and antimicrobial properties of M. longifolia. The antioxidant properties of the seed were determined by hydrogen peroxide scavenging activity and reducing power assay. The methanol extract exhibited more antioxidant activity than water extract. The fungal and bacterial pathogens used for the study were isolated from the skin scraping of infected animals. The methanol and water extracts of M. longifolia seedswere tested for their antimicrobial efficacy against the pathogens. Methanol extract exhibited good antimicrobial property than water extract. From the above findings it is confirmed that the seeds of M. longifolia posses good antioxidant and antimicrobial...
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Posted by admin on Dec 1, 2014 in |
Background: Prescription of drugs which needs to be continuously assessed and refined according to disease progression. It not only reflects the physician’s knowledge about drugs but also know the pathophysiology of diseases and attitude towards rational prescribing. Methods: Retrospective study was carried out by collecting 350 prescriptions containing antimicrobial agents of the indoor patients admitted in the wards of Paediatric department at Sir Sayajirao General (SSG) Hospital, Vadodara. The data was collected by using case record form specially prepared for the study. Results: In our study, total 350 prescriptions containing 690 antimicrobial agents were prescribed during study period. Average number of antimicrobials per prescription was 1.97. 576(83.48%) and 114(16.52%) antimicrobials were prescribed by using generic name and trade name respectively. 599(86.81%)and 91(13.18%) antimicrobial agents were prescribed for parenteral administration as well as oral route respectively. 101(28.85%) prescriptions constitute single antimicrobial agents, while 249(71.14%) prescriptions contain either two or more than two antimicrobial agents. Among all prescriptions 3 % and 11% of them were without the age and address of...
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Posted by admin on Dec 1, 2014 in |
Some new Sb(III) and As(III) complexes of N∩S donor ligands N’-[1-(2-oxo-2H-chrome-3yl-ethylidene] – hydrazinecarbodithionic acid methyl ester (L1H) and N’ – [1-(2-oxo-2H-chrome-3yl – ethylidene] -hydrazinecarbodithionic acid benzyl ester (L2H) have been synthesized. All the synthesized compounds were characterized by elemental analyses, melting point determinations and a combination of electronic, IR, 1H NMR, and X-ray diffraction spectroscopic techniques. These studies showed that the ligands coordinated to organoantimony and organoarsenic in a monobasic bidentate manner through sulfur and nitrogen donor system. Thus, tetra and pentacoordinated environments around the antimony and arsenic atom have been proposed. In order to evaluate the effect of metal ions upon chelation, both the ligands and their complexes have been screened for their antimicrobial activity against the various pathogenic bacterial and fungal strains. The results indicate that the metal complexes are more potent antimicrobial agents than the parent ligands. Further, the ligands and their corresponding metal complexes have been tested for their pesticidal activity against the Corcyra cephalonica. The results of pesticidal screening are quite...
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