EVALUATION OF ANTIDIABETIC POTENTIAL OF METHANOLIC EXTRACT OF COCCINIA INDICA LEAVES IN STREPTOZOTOCIN INDUCED DIABETIC RATS
Coccinia indica is a climbing, herbaceous, branched tropical vine native to tropical Asia, including India. Being a part of Indian traditional medicine for ages, it has been widely used in reducing blood sugar among various other uses. The primary objective of this study was to investigate the reported anti-diabetic potential of methanolic polyherbal extract of Coccinia indica leaves in streptozot...
TO STUDY THE EFFECTS OF SOLVENT AND RELATIVE HUMIDITY ON RHEOLOGICAL AND THERMAL PROPERTIES OF MICROCRYSTALLINE CELLULOSE GRANULES USING HYDROXYPROPYL METHYLCELLULOSE AS BINDER
Solvent used for preparing binder solution in a wet granulation process is one of the major factors which dictate the granule properties. Aim of our current research was to understand the effect of solvents on flow properties of Microcrystalline Cellulose granules prepared using Hydroxypropyl Methylcellulose as a binder by using rheological tools and subsequently studying the effect of relative hu...
ANTIBACTERIAL ACTIVITY, PHYTOCHEMICAL SCREENING AND ANTIOXIDANT ACTIVITY OF STEM OF NICOTIANA TABACUM
The parts of the Nicotiana tabacum plant have been known to possess a wide range of biological activities. The purpose of the present study was to investigate the antibacterial activity, phytochemical screening and the antioxidant activity of aqueous and alcoholic extracts of the stem of Nicotiana tabacum. The antibacterial activity was observed against two gram positive bacteria (Bacillus amyloiq...
IN VITRO EVALUATION OF CYTOTOXIC, ANTIBACTERIAL, ANTIOXIDANT AND PHYTOCHEMICAL SCREENING OF PETROLEUM ETHER EXTRACT OF PHYLLANTHUS ACIDUS
The in vitro activity of the petroleum ether extract of fruit part of Phyllanthus acidus was tested for cytotoxic antibacterial and antioxidant activities as well as for phytochemical screening. The plant was collected from Savar, Dhaka. Phytochemical screening of petroleum extract of phyllanthus acidus revealed the presence of carbohydrate, glycoside and steroid. The extract exhibited antibacteri...
Many drugs exist in crystalline solid form due to reasons of stability and ease of handling during the various stages of drug development. Crystalline solids can exist in the form of polymorphs, solvates or hydrates. Phase transitions such as polymorph inter-conversion, formation of hydrates, desolvation of solvates, and conversion of the crystalline to amorphous form may occur during various phar...
Lawsonia inermis L. (Lawsone) is reported to contain carbohydrates, proteins, flavonoids and phenolic compounds, alkaloids, terpenoids, coumarins, xanthones and fatty acids. The plant has also been reported to have hepatoprotective, anti-inflammatory, antibacterial, antifungal, antiviral, antioxidant and anticancer properties. Lawsone has low bioavailability because it is less soluble in water and...
Ziziphus mauritiana belongs to family Rhamnaceae and commonly known as Indian jujube or ber. The leaves are alternate and elliptic. Flowers are small and bisexual. The leaves are about 2.5 – 3.2 cm long. Commercially it is cultivated in China & India. Ziziphus mauritiana is small to medium sized spiny tree. The chemical compositions of the leaves are proteins & amino acids, flavonoids, a...
DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS DETERMINATION OF CEFPODOXIME PROXETIL AND OFLOXACIN IN TABLETS
The present manuscript describes simple, sensitive, rapid, accurate, precise and economical spectrophotometric method for the simultaneous determination of cefpodoxime proxetil and ofloxacin in combined tablet dosage form. The method is based on the simultaneous equations for analysis of both the drugs using methanol as solvent. Cefpodoxime proxetil has absorabance maxima at 236 nm and ofloxacin h...
Castor (Ricinus communis L, Euphorbiaceous) is needed in the United States to supply caster oil for the hundred of products using this versatile chemurgical raw material. 40-45 thousand tons of castor oil and derivatives are imported each year. Ricinus communis is a common medicinal plant in Ayurveda and is used several part of country for various medicinal properties like the oil of leaf and root...
The proposed method is new, simple, sensitive, reproducible, economical, accurate and precise and can be successfully applied in estimation of Telmisartan (Telmi) from urine. This method can find applications in clinical studies and therapeutic drug monitoring. This method of colorimetric estimation of telmisartan from urine is based on the formation of yellow colored chromogen when it is reacted ...