The transdermal route of drug delivery has attracted researchers due to many biomedical advantages associated with it. However, excellent impervious nature of skin is the greatest challenge that has to be overcome for successfully delivering drug molecules to the systemic circulation by this route. This review describes enhancement techniques based on drug/vehicle optimization such as physical and...
Mosquitoes transmit serious human diseases causing millions of deaths every year. Phytochemistry has proven that there are potential mosquito control agents and also alternatives to synthetic insecticides. The present paper reports Ageratum conyzoides commonly known as Kubhi in Hindi of family Astereacae. The plant after proper identification was collected shade dried and powdered to the fine mesh...
CRINUM; AN ENDLESS SOURCE OF BIOACTIVE PRINCIPLES: A REVIEW. PART 1- CRINUM ALKALOIDS: LYCORINE-TYPE ALKALOIDS
Crinum is an important Amaryllidaceous plant thanks to the valuable biological and therapeutic activities of its chemical constituents, especially alkaloids. Many Crinum species have been commonly used in traditional medicines worldwide. Long ago, they have been subjected to extensive chemical, cytological and pharmacological investigations. Accordingly, this work comprehensively comprises both th...
The oral delivery of lipophilic drugs presents a major challenge because of the low aqueous solubility and less bioavailability. Self-micro emulsifying drug delivery systems (SMEDDSs) have gained exposure for their ability to increase solubility and bioavailability. SMEDDS, which are isotropic mixtures of oils, surfactants, solvents and co-solvents/surfactants, can be used for the design of formul...
A number of prenylated benzoic acids derivatives with interesting biological activities have been previously isolated and characterized from different species of piperaceae family. Several Piper species contained structurally similar compounds with diverse biological activities such as anti-bacterial, anti-fungal, insecticidal as well as anti-parasitic all of which produces compounds that can be c...
The present work aim was “Formulation Strategy for Dissolution Enhancement of Simvastatin”. Simvastatin is lipid lowering drug which is known as HMG CoA reductase. The objective of this study was to increase the solubility of poorly water soluble drug, namely simvastatin, by the formation of solid dispersion and complex and also using the microwave induction technique on these formations. For ...
Artemisia annua L., also known as sweet wormwood, sweet annie, sweet sagewort and annual wormwood (Chinese: qngho), is a common type of wormwood that is native to temperate Asia, but naturalized throughout the world, and that belongs to the family of the Asteraceae. Currently, Artemisia annua is the source for the production of artemisinin and semi-synthetic artemisinin derivatives (including dihy...
COMPARATIVE STUDY OF PHENOLICS AND ANTIOXIDANT ACTIVITY OF PHYTOCHEMICALS OF T.CHEBULA EXTRACTED USING MICROWAVE AND ULTRASONICATION
The extraction of active compounds from plants is one of the most critical steps in the commercial development of natural products for medicinal and health benefits. In view of the large number of plant species potentially available for study, it is essential to have efficient systems for the rapid and efficient extraction of phytochemicals for further investigation on their properties. The presen...
CHEMICALLY FABRICATED SILVER NANOPARTICLES ENHANCES THE ACTIVITY OF ANTIBIOTICS AGAINST SELECTED HUMAN BACTERIAL PATHOGENS
Due to the outbreak of infectious diseases caused by different pathogenic bacteria and the development of antibiotic resistance, the pharmaceutical companies and the researchers are now searching for new unconventional antibacterial agents. Nanotechnology represents a modern and innovative approach to develop new formulations based on metallic nanoparticles with antimicrobial properties. The pot...
ASSESSMENT OF ANTIMICROBIAL AND CYTOTOXIC ACTIVITIES OF ETHANOLIC EXTRACT OF LEAVES OF ACALYPHA HISPIDA
The ethanolic extract of leaves of Acalypha hispida was evaluated for phytochemical, cytotoxic and antibacterial activities. Phytochemical studies revealed the presence of flavonoids, saponins, glycosides, reducing sugars and steroids. Cytotoxic activity was investigated by brine shrimp (Artemia salina) lethality assay. The extract showed potent cytotoxic effect (LC50 19.95µg/ml) which is compara...