Solubility of orally administered drug is major challenge of pharmaceutical industry as nearly 35-40% of newly launched drugs possess low aqueous solubility which leads to their poor dissolution and low bioavailability, resulting in high intra & inter subject variability & lack of dose proportionality. This can be increased by different methods like salt formation, solid dispersion and com...
Alzheimer’s disease, a neurodegenerative disorder is characterized by intense memory loss enough to interfere with social and occupational execution.It is the most general form of dementia, affecting more than 20 million people worldwide. The treatments of Alzheimer's disease are through cholinesterase inhibitors or NMDA-receptor antagonists, while doubts remain about the therapeutic efficacy of...
The ethanolic extract of bark of Dalbergia sissoo Roxb. was investigated for its activity against Indian earthworms Pheretima posthuma and nematode Ascardi galli. Various concentrations (10, 20, 50 mg/ml) of ethanolic extract were tested, which involved determination of time of paralysis and time of death of the worms. It was compared with Piperazine citrate (15 mg/ml) and Albendazole (20 mg/ml) a...
Some plants are toxic to living beings including humans, and are widely used all over the world in the treatment of various types of body ailments in traditional medicine, especially in the developing countries, due to theirs economic, social and cultural conditions. These plants are routinely taken for the nourishment of the pregnant women. This may cause the toxicity to the developing foetus, kn...
PATTERNS OF MATERNAL MORTALITY AND ASSOCIATED FACTORS; A CASE-CONTROL STUDY AT PUBLIC HOSPITALS IN TIGRAY REGION, ETHIOPIA, 2012
Background: Maternal mortality is one of the indicators in the millennium development goal that is raising concern in achieving the set target of reducing the rate by three-fourth by 2015. Women who die due to pregnancy-related causes are in the prime of their lives and are responsible for the health and well-being of their families. Objective: To assess patterns of maternal mortality and assoc...
The aim of this research wok is to formulate and evaluate Ciprofloxacin solid dispersions system by using the different techniques. This will increase the solubility of the drug or Ciprofloxacin and give the immediate release of the drug from the formulations. The main objective is to formulate a drug product as immediate release oral solid dosage form of Ciprofloxacin solid dispersion system whic...
Diabetes is a major public health problem. Diabetes mellitus now affects large number of people in many developing countries than western countries where only two or three percent of the population is affected. With on estimated 33 million people in India alone affected by diabetes. It is a major epidemic of the twentieth century. Diabetes is a chronic disorder, which is associated with obesity, h...
GASTRORETENTIVE DRUG DELIVERY SYSTEM: AN APPROACH TO ENHANCE GASTRIC RETENTION FOR PROLONGED DRUG RELEASE
Oral route has been the most convenient and accepted route of drug delivery. Owing to tremendous curative benefits of the oral controlled release dosage forms are being preferred as the interesting topic in pharmaceutical field to achieved improved therapeutics advantages. Gastroretentive drug delivery system is novel drug delivery systems which has an upper hand owing to its ability of prolonged ...
A COMPARATIVE STUDY OF THE ANTIOXIDANT, ANTIMICROBIAL AND THROMBOLYTIC ACTIVITY OF THE BARK AND LEAVES OF LANNEA COROMANDELICA (ANACARDIACEAE)
The present study was designed to compare the antioxidant, antimicrobial and thrombolytic effects of the Lannea coromandelica bark and leave extracts. After the initial phytochemical screening, the ethanolic fractions of the L. coromandelica bark and leaves were partitioned by solvents of different polarity. Methods used to evaluate the antioxidant potential of the extracts were total phenolic con...
Over the past decades, herbal medicine has become a thing of global significance with medicinal and economic implications. Wide spread use of herbs throughout the globe has raised serious concerns over its quality, safety, and efficacy. Our investigation showed that these investigated medicinal plants could prevent ulcer in a dose-dependent manner. Histological studies revealed that these medicina...