Solid dispersions have been employed to enhance the dissolution rates of poorly water-soluble drugs. Many approaches have been investigated for the preparation of solid dispersions. This paper reports the various solubility enhancement strategies in solid dispersion. The approaches described are fusion (melting), solvent evaporation, lyophilization (freeze drying), melt agglomeration process, extr...
The aim of the study was to evaluate the circulating antioxidant such as vitamin C, vitamin E and GSH in nickel (Ni) induced toxicity in rats and in vitro free radical scavenging assay. In this investigation nickel sulfate (20 mg/kg body weight (b.w.) was administered intraperitoneally (i.p.) for 20 days to induce toxicity. Naringin was administered orally (80 mg/kg body weight) for 20 days with i...
Recently, controlled and sustained drug delivery has become the standard in modern pharmaceutical design and an intensive research have been undertaken in achieving much better drug product effectiveness, reliability and safety. This interest has been sparked by the advantages shown by in situ gelforming drug delivery systems such as ease of administration and reduced frequency of administration, ...
A VALIDATED RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF AMLODIPINE AND LISINOPRIL IN PHARMACEUTICAL DOSAGE FORM
A reverse phase high performance liquid chromatography (RP-HPLC) method for the simultaneous estimation of amlodipine and lisinopril in marketed formulation is developed. The determination was carried out on a Phenomenex C18 (250 x 4.6 mm, 5 µm) column using a mobile phase of 0.02 M phosphate buffer solution: methanol (75:25v/v, pH 7.0). The flow rate was 1.0ml/min with detection at 212 nm. The ...
HISTOCHEMICAL AND PHYTOCHEMICAL MARKERS FOR THE AUTHENTICATION OF AYURVEDIC RAW DRUG HALLAKAM (KAEMPFERIA ROTUNDA) AND ITS MARKETED ADULTERANT
Comparative pharmacognostic and phytochemical studies are the reliable source to identify the genuine raw drug from its adulterants. This paper deals with the characterization of the repute ayurvedic drug hallakam from its substitute/adulterants. Ayurvedic experts equated rhizomes of Kaempferia rotunda L. of Zingiberaceae as hallakam and in certain market samples Lagenandra toxicaria Dalz. is also...
Nasal drug delivery has occupied an important place in the field of drug delivery technology. Transmucosal nasal delivery is a promising drug delivery option where common drug administration’s (e.g. intravenous, intramuscular, and oral) are inapplicable. This route is also advisable for drugs undergoing extensive first pass effect. The physiology of the nose presents obstacles, but offers a prom...
PHYTOCHEMICAL ANALYSIS OF TINOSPORA CORDIFOLIA (WILLD.) MIERS EX HOOK. F. & THOMS STEM OF VARIED THICKNESS
Tinospora cordifolia (Giloe/Guduchi) belonging to the family menispermaceae, is a large extensively spreading glabrous, perennial deciduous twiner with succulent stems and papery bark. It is widely used in Ayurvedic system of medicine “Rasayanas” to the immune system and the body resistance against infections. In modern medicine, T. cordifolia is used for the treatment of general weakness, fev...
Many herbal remedies have been employed in various medical systems for treatment and management of different diseases. The plant Oxalis corniculata Linn. has been used in different system of traditional medication for the treatment of diseases and ailments of human beings. β-sitosterol, betulin, 4-hydroxybenzoic acid, ethyl gallate, methoxyflavones, apigenin, and 7-O-β-D-glucopyranoside were pre...
PRODUCTION OF REACTIVE OXYGEN SPECIES, ITS EFFECT, DRUGS AND PLANT EXTRACT USED AS AN ANTIOXIDANT, CHELATOR ON THALASSEMIC PATIENT: A REVIEW
β- Thalassemia is an inherited genetic disorder which is caused by different kinds of mutations in the HBB gene in chromosome 11. Due to several types of mutation in β- gene, globin chains cannot synthesise completely and free α-globin is highly unstable and readily precipitates bound heme and iron. In β- thalassemia these precipitated iron, repeated blood transfusion and increased gastroint...
Buccal controlled drug delivery system has been developed since the environment of the oral cavity provides potential sites for drug delivery. The acid hydrolysis and first pass effects can be avoided. The release of drug can be affected by continuous secretion of saliva. The mucin film exists in oral mucosa offers an opportunity to develop mucoadhesive system, which retain at absorption site for ...