The nanoemulsion is one of the most efficient dispersed nanosystems of droplet size ranging to submicron size. Nanoemulsions/ Sub-micron emulsions (SMEs)/ Mini-emulsions are thermodynamically stable transparent or translucent dispersions of oil and water stabilized by an interfacial film of surfactant and co surfactant molecules having a droplet size of less than 100 nm. This review provides bri...
AN ETHANOLIC EXTRACT FROM LICORICE (GLYCYRRHIZA GLABRA) EXHIBITS ANTI-OBESITY EFFECTS BY DECREASING DIETARY FAT ABSORPTION IN A HIGH FAT DIET-INDUCED OBESITY RAT MODEL
The present study was to investigate the anti-obesity effects of the freeze dried powder of ethanolic extract of Licorice (Glycyrrhiza Glabra) (LP) in a rat model of high-fat diet induced obesity and hyperlipidemia. Male wistar rats were fed with a high-fat diet for 8 weeks to induce obesity and hyperlipidemia. High fat diet induced obese rats exhibited increases in body weight gain, adipose tissu...
TAHLAB (SPIRULINA) AND FEW OTHER MEDICINAL PLANTS HAVING ANTI-OXIDANT & IMMUNOMODULATORY PROPERTIES DESCRIBED IN UNANI MEDICINE – A REVIEW
Antioxidants are substances that may protect cells from the damage caused by unstable molecules known as free radicals; free radicals damage may lead to cancer and other diseases. Some of the example of antioxidants are like β-carotene, lycopene, Vit. C, E & A and other substances which are found in variety of fruits, vegetables, algae (spirulina) & other medicinal plants. Spirulina (Blue...
DEVELOPMENT AND VALIDATION OF SPECTROFLUORIMETRIC METHOD FOR THE ESTIMATION OF VOGLIBOSE IN BULK AND PHARMACEUTICAL DOSAGE FORM
A simple, accurate, sensitive, reproducible and cost – effective spectrofluorimetric method was developed for the estimation of voglibose in bulk and pharmaceutical formulations. The solvent systems, wavelengths of detection (excitation and emission) were optimized in order to maximize the sensitivity and minimize the cost of analysis for voglibose. Derivatization procedure was employed for anal...
A FACTORIAL STUDY ON FORMULATION DEVELOPMENT OF IBUPROFEN TABLETS EMPLOYING STARCH 1500 AND PVP K 30
Ibuprofen, a widely prescribed anti-inflammatory and analgesic drug belongs to class II under BCS and exhibit low and variable oral bioavailability due to its poor aqueous solubility. Solid dispersion of ibuprofen in Starch 1500, a modified starch and polyvinyl pyrrolidone (PVP K 30) was investigated to enhance the dissolution rate and to develop ibuprofen tablets with fast dissolution characteris...
As part of our ongoing study to screen local herbs for their possible usefulness as anti-infectives, we assessed extracts from 16 medicinal plants for their antibacterial properties and their influence on the activity of amoxicillin. The minimum inhibitory concentrations (MIC) of amoxicillin against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli and Salmonella t...
INFUSIBLE PLATELET MEMBRANES IMPROVE HEMOSTASIS IN THROMBOCYTOPENIC RABBITS: STUDIES WITH TWO DIFFERENT INJECTION DOSES
Due to the limited life span of platelets during regular storage in blood banks, we were interested to investigate the both potential hemostatic effect and dose-dependent response properties of non-viable platelet preparations with injection of two high and low doses in experimental animal model. Infusible platelet membrane (IPM) was prepared from outdated platelet concentrates. Platelet concentra...
The bioavailability of some orally administered botanical extracts is erratic and poor due to limited gastro-intestinal absorption. Bioavailability can be improved by using new delivery systems which can enhance the rate and the extent of solubilization into aqueous intestinal fluids and the capacity to cross biomembranes. Phospholipids based drug delivery system have been found promising for bett...
ADVERSE DRUG REACTION MONITORING AND REPORTING: KNOWLEDGE, ATTITUDE AND BELIEF OF PHYSICIANS & PHARMACISTS OF RAS AL KHAIMAH, UNITED ARAB EMIRATES (UAE)
Adverse drug reactions (ADR) contribute significantly in health care cost through increased patient morbidity and mortality. Thus, there is an urgent need to create awareness among health care professionals towards ADR monitoring and reporting. The aim of our study is to assess the knowledge, attitude and belief of physicians and pharmacists towards ADR. This is a prospective cross-sectional surve...
Paracetamol was formulated as lozenges to provide slow release medicament for the management of fever and pain. There are many dosage forms like syrups, tablets, inhalers are available in the market but still there is a need for new dosage forms which acts effectively and locally. So the present investigation has been taken up to design, prepare and evaluated tablet lozenges to meet the need of im...