A reliable, rapid, simple and accurate high-performance liquid chromatography method with UV detection was developed for the simultaneous quantitative determination of strychnine in a polyherbal formulation prepared from Nux Vomica. Krimimudgara rasa, a herbal dosage form containing Strychnos nux vomica, Apium graveolens, Embellia ribes, Butea monosperma in combination. Separation of the strychnin...
A STUDY OF SPECIALIZED TROCAR OF REMOVING CUFFED CATHETER AMONG PATIENTS SUFFERING FROM HEMODIALYSIS
Background: Permanent cuffed catheter (permcath) is a method used to access the veins in hemodialysis. In those patients with catheter exit indication, a small incision is made on the skin after feeling the cuff under the skin and catheter is removed after disconnecting its tissue-cuff connection. In this study, the whole connection between catheter cuff and tissue is disconnected using a new tool...
METHOD DEVELOPMENT, VALIDATION AND STABILITY INDICATING ASSAY FOR TENELIGLIPTIN HYDROBROMIDE BY RP-UFLC
The study aimed to develop a specific, exact, selective, precise and accurate Reversed Phase Stability Indicating Ultra-fast Liquid Chromatography (RP-UFLC) strategy is created and validated for Teneligliptin hydrobromide in the pure and marketed formulation. The method showed an adequate separation for Teneligliptin hydrobromide from their degradation products. The chromatographic separation was ...
From the beginning of civilization, humans depend on the natural products for their food and as medical treatment. Diversity in various bioactive compounds from marine organisms has been tested for the multiple pharmacological effects. Marine algae are surviving in a competitive environment with developed defense strategies and significant levels of chemical structural diversity with a wide variet...
PROTECTIVE EFFECTS OF ALOE VERA AGAINST RADIATION INDUCED BIOCHEMICAL DISORDERS IN LIVER OF SWISS ALBINO MICE
In this study, radioprotection against radiation-induced hepatic damage in Swiss albino mice has been observed by Aloe vera. When individuals are exposed, the radiation energy is absorbed by the biological systems, which causes radiolysis of tissue water and generates free radicals. Animals were given Aloe vera leaf extract orally 1000 mg/kg body weight/day for 15 consecutive days before radiation...
Lipid-based drug delivery systems in the form of triglyceride emulsions, micellar systems and liposomes have been used for parenteral administration for the last few decades. Large number of new chemical entities (NCE) presents formulation and bioavailability problems because of the dose and poor solubility in solvent and co-solvent systems. In addition, high drug concentrations can lead to irrita...
ESTIMATION OF PROTEINS IN PLANTS OF FORENSIC SIGNIFICANCE (RICINUS COMMUNIS AND CANNABIS SATIVA) BY UV-SPECTROPHOTOMETRY AND GEL ELECTROPHORESIS METHOD
Proteins play a significant role in living beings. In animals, where proteins are involved in the body built, the formation of tissues, organs, etc., in plants, proteins regulate the respiration, photosynthesis, growth, and reproduction. There are some proteins which are specific to the plant or a particular species of plant. Proteomics is a multidisciplinary branch of science that deals with the ...
The present study investigated the protective role of methanolic extract from Anethum graveolense L. (AGME) on bile duct ligation (BDL) produce hepatic fibrosis in the rat. BDL rats were divided into four groups, which received orally distilled water or AGME (200 and 400 mg/kg) for continuously 28 days. The BDL induced hepatic fibrosis by anti-fibrotic effect of AGME in the rats determined by seru...
FORMULATION AND EVALUATION OF SPHERICAL CRYSTALS OF INDOMETHACIN FOR THE IMPROVEMENT OF SOLUBILITY AND MICROMERITIC PROPERTIES
Indomethacin, an anti-inflammatory drug, exhibits poor water solubility and flow properties. Spherical agglomerates were prepared by crystallo-co agglomeration technique. Crystallization medium used for spherical agglomerates of Indomethacin consisted of acetone (good solvent); water (poor solvent); dichloromethane (bridging liquid). HPMC, PVP and PEG6000 this polymer were used in the agglomeratio...
Background: Cervical cancer (CC) is the second leading cause of cancer deaths in women, with more than 80% of these occurring in developing countries that have limited access to screening programs. Therefore there is a need to develop diagnostic and prognostic biomarkers which can be quantifiable and help clinical oncologists at the first interaction with the suspected patients. The aim of this st...