OPTIMIZATION OF ULTRASOUND-ASSISTED EXTRACTION OF PHENOLIC COMPOUNDS FROM AMMI VISNAGA USING RESPONSE SURFACE METHODOLOGY
In this study, response surface methodology (RSM) was used to optimize ultrasound-assisted extraction (UAE) conditions for obtaining the maximum yield and content of phenolic compounds of Ammi visnaga extracts (EAV). Three independent variables including ethanol concentration (%), extraction time (time) and solvent-to-material ration (mL/g) were studied. The results showed that the optimal UAE con...
IN- VITRO ANTIOXIDANT PROPERTIES, ACUTE AND SUBACUTE TOXICITY STUDIES OF TEPHROSIA CALOPHYLLA ON ALBINO WISTAR RATS
The evaluation of acute oral toxicity of chloroform extract of Tephrosia calophylla (CETC) and methanolic extract of Tephrosia calophylla (METC) and sub-acute toxicity of CETC was done on albino Wistar rats. The animals (female) were divided into four groups containing 3 animals in each group normal control, and 200, 400 and 800 mg/kg of freshly prepared extracts respectively, every 24 h orally fo...
Cinnarizine was microencapsulated with Eudragit RS100 using an o/o and o/w emulsion solvent evaporation technique. The effects of three formulation variables including the drug: polymer ratio, emulsifier (polyvinyl alcohol) concentration and volume of external medium on the entrapment efficiency and microspheres size distribution were examined. The drug release rate from prepared microspheres and ...
DUAL ROLE OF ARJUNOLIC ACID AND B12 IN MITIGATING SODIUM ARSENITE INDUCED MALFUNCTION OF FEMALE REPRODUCTIVE ORGANS
The present study was proposed to delineate the curative role of arjunolic acid and vitamin B12 alone or in combination against arsenic induced oxidative stress and female reproductive dysfunction. The Wistar strain adult female rats were treated with sodium arsenite at the dose of 1.0 mg/100 gm body weight orally for first eight days. Next eight days rats were treated with arjunolic acid (1.0 mg/...
ETHNOMEDICINAL PLANTS AND THEIR CONTRIBUTION TO CURE VARIOUS AILMENTS AS HOUSEHOLD REMEDIES IN GARHWAL HIMALAYA, INDIA
The present investigation was carried out in five villages of the marginalized hill area block of Dewal in Chamoli district, regarding the uses of mild and native ethno-medicinal plants, by locals in their traditional health care system. The people residing in this area have been in isolation for centuries and possess good knowledge of phytotherapy. A total of 51 species of medicinal plants (both ...
MOLECULAR DOCKING ANALYSIS OF 3- SUBSTITUTED 5-HYDROXY COUMARIN DERIVATIVES AS VITAMIN K EPOXIDE REDUCTASE INHIBITOR
Warfarin and coumarin containing drugs act on Vitamin K epoxide reductase to show its anti-coagulant activity. In this study, three different series of 5- hydroxy coumarin containing phenyl, furan and pyran substituents at third position were designed. Molecular docking studies were performed to determine binding modes and affinities of ligand molecule towards Vitamin K epoxide reductase. In docki...
ANTIBACTERIAL ACTIVITY OF NIGELLA SATIVA EXTRACTS AGAINST EXTENDED SPECTRUM Β-LACTAMASE PRODUCING ESCHERICHIA COLI ISOLATES
The most striking feature of natural products in connection to their long-lasting importance in drug discovery is their structural diversity that is still largely untapped. Most natural products are not only sterically more complex than synthetic compounds but also differ in regards to the statistical distribution of functionalities. The chemical diversity and unique biological activities of a wid...
Surface disinfectant is the multi-billion-dollar global industry with continuous growth opportunities linked to advancements in technology and innovations. However, innovations and new advancements do not always reach consumers due to the lack of clarity related to the approval process of such innovations and stringent regulations by national health authorities. These regulations can pose challeng...
SIMULTANEOUS EQUATION METHOD AND ABSORPTION CORRECTION METHOD FOR THE ESTIMATION OF PERINDOPRIL ERBUMINE AND AMLODIPINE BESYLATE IN BULK AND IN COMBINED TABLET DOSAGE FORM USING UV SPECTOPHOTOMETRY
In the present work a simple, accurate and precise method has been developed and validated for the simultaneous estimation of Perindopril Erbumine (PDE), Amlodipine Besylate (AMD)and in their combined dosage form by UV Spectrophotometric Methods. The Method A employs estimation of drugs by simultaneous equation method (SEM) using 298.3 nm and 231.9nm i.e. λmax values of PDE and AMD respectively. ...
Background: The association between metabolic syndrome and cognitive impairment is not well established. The aim of the present study was to estimate the prevalence of cognitive impairment in adults with metabolic syndrome (MetS). Methods: Cross-sectional observational study conducted in patients with metabolic syndrome (n=185). All patients were subjected to written informed consent, anthropometr...