ASSESSING THE GENOTOXIC AND CYTOTOXIC RESPONSES OF THE H-29 CANCER CELL LINES ON THE ETHANOLIC EXTRACTS OF THE OYSTER MUSHROOM, PLEUROTUS OSTREATUS VAR. FLORIDA
Globally, colorectal cancer is the third most common known today. Lack of cheap, rapid, safe and reliable cancer treatments resulted to the continued pursuit to find natural sources of bioactive compounds that can be cytotoxic or damaging to the DNA of cancer cells. One of the potential resource is the edible oyster mushroom (Pleurotus ostreatus var Florida) reported to have medicinal properties. ...
DESIGN OF CONTROLLED RELEASE NON-ERODIBLE POLYMERIC ATENOLOL MATRIX TABLET USING MICROWAVE OVEN-ASSISTED SINTERING TECHNIQUE
The objective of the present study was to evaluate the effect of microwave sintering condition on matrix formation and subsequent drug release from polymer matrix tablet for controlled release. The Atenolol floating SR matrix tablets were prepared by using tragacanth, sodium bicarbonate, Eudragit S-100 and citric acid was incorporated as a gas generating agents. Atenolol controlled release tablets...
Terminalia catappa Linn. belongs to the family Combretraceae found in tropical regions of Asia, Africa and Australia, which is commonly called as Indian almond, sea-almond, tropical almond, wild badam. The fruit is useful in bronchitis and bowels. Juice of leaves is used in the preparation of the ointment for scabies, leprosy, cutaneous diseases and also as analgesic. The root bark is used in dyse...
Bisphenol-A (BPA) is a chemical produced in large volumes worldwide and has large market diffusion in many consumer products. BPA is used mainly as a monomer in the production of polycarbonate plastics and as a precursor of epoxy resins. So the present study was undertaken to examine the toxic effect of BPA on heart function in pregnant rat models. BPA (50 mg/kg.b.wt/day and 500 mg/kg.b.wt/day) wa...
EVALUATION OF ANXIOLYTIC ACTIVITY OF HOMEOPATHIC REMEDY ARGENTUM NITRICUM OF 30 C POTENCY AFTER CHRONIC ADMINISTRATION IN RODENTS
Anxiety affects a large number of the population that creates an economic burden. Various traditional medicines like barbiturates, benzodiazepines and SSRI’s are used as anxiolytics but due to their potential to produce adverse effect on cognition limits their chronic use. Several homeopathic remedies are used for treating anxiety. For the first time this study was designed to determine anxiol...
ANALYSIS OF LIVER FUNCTION TESTS AND RENAL FUNCTION TESTS IN MAJOR DEPRESSIVE PATIENTS ON IMIPRAMINE, SERTRALINE AND ESCITALOPRAM THERAPY: AN OBSERVATIONAL STUDY IN A TERTIARY CARE HOSPITAL, AJMER, RAJASTHAN
Depression is the major cause of disability Worldwide. Antidepressant medications remain a mainstay of treatment for major depressive disorder. Our aim in this study was to analyze the LFT & RFT in patients of major depressive disorder taking imipramine, sertraline and escitalopram. A total of 810 such patients meeting the inclusion and exclusion criteria were randomly divided into three group...
The aim of the study is to investigate the capacity of pyrimidine derivatives like the active ingredient of Xymedon (I) and its derivative, salt-like conjugate with L-ascorbic acid (II) to stimulate liver recovery when damaged by toxic hepatitis. The study was done on out breed white rats. The liver damage was induced by carbon tetrachloride (injected 50% oil solution subcutaneously, once per day,...
ANTIMICROBIAL AND ANTIPLASMODIAL ACTIVITY DISPLAYED BY ACTINOMYCETES ISOLATED FROM SOILS FROM KAVANGO AND HARDAP REGIONS IN NAMIBIA
Plasmodium falciparum and multidrug resistant bacteria such as Mycobacterium avium, Staphylococcus aureus and Escherichia coli are among the top causes of morbidity and mortality especially in developing countries. These pathogens are responsible for the reported antibiotic resistance incidents globally. Due to the increase in antibiotic resistance worldwide, there is an urgent need for new bioact...
QUALITY ASSESSMENT OF SOME BRANDS OF CLARITHROMYCIN AND AZITHROMYCIN TABLETS USING THE CONCEPT OF DISSOLUTION EFFICIENCY AND SIMILARITY FACTOR
Counterfeit and substandard pharmaceutical products circulate widely in developing countries, yet adequate techniques to monitor quality is lacking. We report herein a quick and reliable approach to predict the in-vitro bioequivalence and interchangeability of common antibiotics using nine model drugs; four brands of azithromycin and five brands of clarithromycin tablets marketed in Nigeria. Pharm...
DEVELOPMENT AND VALIDATION OF UV SPECTROSCOPIC METHODS FOR SIMULTANEOUS ESTIMATION OF PARACETAMOL AND ZALTOPROFEN IN BULK AND TABLET FORMULATION
Two methods for simultaneous estimation of Pracetamol and Zaltoprofen in combined tablet dosage form have been developed. The first UV spectrophotometric method was a determination using the simultaneous equation method at 245 nm and 227 nm. The second UV spectrophotometric method is the Q – analysis (absorption ratio) method, which involves the formation of absorbance equation at 237.5 nm (isob...