ANTILITHIATIC ACTIVITY OF ETHANOLIC LEAVES EXTRACT OF DALBERGIA SISSOO LINN. ETHYLENE GLYCOL INDUCED LITHIASIS IN RATS
Aim of the Study: The aim of this study was to investigate the antilithiatic activity of ethanolic leaves extract of Dalbergia sissoo Linn. ethylene glycol induced in rats. Materials and Methods: All the chemicals were analytical grade. Cystone was obtained from from Himalaya Health Care Ltd. The ethanolic extract of plant Dalbergia sissoo Linn. leaves were given with tween 80 as vehicle administe...
ANTIBIOTIC RESISTANCE PATTERNS AND EVALUATION OF TREATMENT IN OUT-PATIENTS WITH URINARY TRACT INFECTIONS IN NEPAL
The study was aimed to investigate the common causative agents of urinary tract infection in community, their resistance pattern to different antibiotics, and the prescribing patterns of antibiotics used for treatment. A total of 200 women attending gynaecology OPD of Tribhuvan University teaching hospital had their urine tested for culture and sensitivity, out of which 85 showed microbial growths...
Polycystic ovary syndrome (PCOS) is one of the most common disorders that occur in women at any age due to the endocrine hormone imbalance. The cause for this disorder is still not identified, but on recent research provided that disorder may be caused by some genetic variation. Predicting and understanding the effects of genetic variation that occurred in the gene are becoming more important for ...
COMPARING GREEN CHEMICAL METHODS AND CHEMICAL METHODS FOR THE SYNTHESIS OF TITANIUM DIOXIDE NANOPARTICLES
Metal nanoparticles are usually synthesized using various chemical methods such as chemical reduction, Solvo-thermal reduction, electrochemical techniques and photochemical reaction in reverse micelles. All these methods are divided into two categories chemical and green chemical. Each having certain advantages and disadvantages. In this study we have tried to give a few examples of these methods ...
SOLID LIPID NANOPARTICAL IN CORPORATED CREAM OF CLOBETASOL-17-PROPIONATE: DEVELOPMENT AND IN-VITRO EVALUATION
The clinical efficacy of glucocorticoids is dependent on its potency and on its ability to be absorbed in to the skin and therefore, reach its site of action. Colloidal drug carriers such as solid lipid nanoparticles could target glucocorticoids to the epidermis, where the anti-inflammatory action takes place. Topical corticosteroids have long been the chronic stage in the treatment of steroid res...
DESIGN OF EXPERIMENT UTILIZATION TO DEVELOP AND VALIDATE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY TECHNIQUE FOR ESTIMATION OF SERTACONAZOLE NITRATE
A novel method of estimation and validation of Sertaconazole nitrate (SER) by Reverse Phase-High Performance Liquid Chromatography coupled with Ultra-violet detection was developed which had high potential in determining drug concentration with more precision and high accuracy. The process of elution was conducted using Phenomenex C18 (250 mm × 4.6 mm i.d., 5.0 μm) using 0.01M monobasic sodium p...
This review summarizes the health benefits of Tender Coconut Water (TCW). TCW is a natural, healthy, nutritious drink from coconut tree widely grown in tropical countries. Indonesia is the larger country with the largest coconut growing country in the world. The active compounds in TCW include methionine, L-arginine, cytokines, selenium, vitamin C, and Zn, Mn and Cu. L-arginine is present in TCW s...
Adipose tissue has immunomodulating effects in rheumatoid arthritis (RA). Previous studies suggested that obesity could negatively affect the response to anti-TNF-α agents. We aimed to determine whether body mass index (BMI) is involved in the response to the anti-CD20 "Rituximab" in RA. In 100 patients with active RA, the BMI was categorized into two groups (<25 kg/m2 and ≥ 25 kg/m2) and ca...
ROLE OF CD4+T CELL SUBSETS IN THE DETERMINATION OF THE CLINICAL OUTCOME OF JAPANESE ENCEPHALITIS INFECTION
Japanese encephalitis is the most common arthropod-borne human encephalitis in the world. JEV clinical outcomes vary from complete recovery to recovery with neuropsychiatric sequelae to death. Contribution of T cells to the control and immunopathology of JEV infection has been reported in various studies. CD4+ T cells were found to be major T cells that has role in protection as well as affecting ...
SCREENING OF PHYTOCHEMICALS AND EVALUATION OF ANTI-MICROBIAL, ANTI-OXIDANT AND IN-VITRO ANTIDIABETIC ACTIVITY OF CRASSULA OVATA LEAVES
The study involved both aqueous extraction and methanolic extraction of the powered leaves, which ensure all plant components are extracted for better results. Phytochemical analysis from the extracts was performed using the standard protocols. The antimicrobial susceptibility of the extracts was tested against E-coli, Pseudomonas and Klebsilla sp using agar disc diffusion method. Antioxidant pr...