Aim: To study the relationship between serum Vitamin D levels and insulin resistance in obese and non obese adolescents. Introduction: Vitamin D deficiency in obese adolescent is strongly associated with increased risk for diabetes, hyper tension and metabolic syndrome. Vitamin D insufficiency is a risk factor for developing impaired glucose in childhood obesity and is associated with insulin ...
A series of different 6-Methyl - 4- aryl -5 - (5-aryl -1,3,4-oxadiazole-2-yl ) -1,2,3,4-tetrahydro pyrimidin-2- (1H) - one / thione ( IIIa-g) have been synthesised fromEthyl - 6- methyl- 2- oxo / thioxo – 4-substituted phenyl-1,2,3,4-tetrahydro pyrimidine-5-carboxylate (Ia-g) followed by reaction with hydrazine hydrate in ethanol gave 6 - methyl-2-oxo / thioxo – 4 -substituted phenyl - 1,2...
Proteins are the most essential and versatile macromolecules of life, and the knowledge of their functions is a crucial link in the development of new drugs, better crops, and even the development of synthetic biochemicals such as biofuels. Experimental procedures for protein function prediction are inherently low throughput and are thus unable to annotate a non-trivial fraction of proteins that a...
The objective of the present work was to set up micro-coulometric technique in the laboratory and estimate microgram level quantity of nitrofurantoin in the pharmaceutical tablets. A simple, sensitive, and reproducible manually operated microcoulometric technique has been successfully used for the estimation of nitrofurantoin in pharmaceutical tablets. A potentostat and coulometric cell was used i...
EVALUATION OF SERUM ADIPONECTIN AND ADIPOQ +45 T>G POLYMORPHISM WITH METABOLIC SYNDROME IN TUNISIAN POPULATION
Adiponectin has been schown to protect from insulin resistance, demonstrate anti-inflammatory and anti-atherosclerotic effects and be involved in the pathogenesis of metabolic syndrome (MS). We aimed to assess the association between serum adiponectin concentration, insulin resistance and various risk factors of MS and to investigate the relationship between the single nucleotide polymorphism (S...
Diabetes is a chronic disease caused by inherited or acquired deficiency in insulin secretion and by decreased responsiveness of the organs to secreted insulin. The protective effect of aqueous extract of Plumeria Rubra was studied against streptozotocin (STZ) induced diabetes in rats. Plumeria rubra was administered orally at 3 dose levels (100, 200, 400mg/kg). Plumeria rubra extract and standard...
SIMULTANEOUS DETERMINATION OF ETODOLAC AND PARACETAMOL IN BULK DRUGS AND PHARMACEUTICAL FORMULATION BY HPTLC-DENSITOMETRIC AND UV-DERIVATIVE SPECTROPHOTOMETRY METHODS
In current research work two methods have been developed for simultaneous determination of etodolac and paracetamol in binary mixtures. HPTLC-densitometry was employed for the determination of the mixture for etodolac 50-400 ng band⁻¹ and for paracetamol 50-300 ng band⁻¹. Separation was carried out on a silica gel 60 F254 HPTLC plates, using toluene: acetone: methanol: glacial acetic acid (6...
A topological index is a numeric quantity from the structural graph of a molecule. It has become a very useful tool in the prediction of pharmacological, toxicological and physico - chemical properties of a compound. In this paper, we have computed some topological indices of triangular silicate TsL (n) and triangular oxide TOL (n) networks....
Pluronic lecithin organogels (PLOs) are thermo-dynamically stable, biocompatible, viscoelastic with improve drug permeation and localised action. PLOs have gained much popularity compared with other traditional topical and transdermal drug delivery system owing to their lower cost, flexibility of dose and longer contact time. PLOs enhances the permeability of drugs because of desired drug partitio...
COMPARATIVE EVALUATION OF THE EFFECT OF STANNOUS CHLORIDE (SnCl2) AND DIMETHYLTIN DICHLORIDE (DMTC) ON DIAZOTROPHIC GROWTH AND NITROGEN METABOLISM OF NOSTOC MUSCORUM
Stannous chloride (SnCl2), an inorganic salt and Dimethyltin dichloride (DMTC), the organic species were found to influence the survival and nitrogen assimilatory system of Nostoc muscorum. A difference in the survival fractions suggested for differential susceptibility of the strain to the toxic effects of the either tin species. Growth of the Nostoc muscorum cells, measured as a function of grad...