The present work was undertaken to justify that Vigna radiate (green moong bean) is helpful in reversing signs of memory loss in aged mice. Passive Avoidance Paradigm (PAP) and Elevated Plus Maze (EPM) were employed as exteroceptive behavioural models and ageing- induced amnesia served as interoceptive behavioural model. Moong bean sprouts (2% and 4% w/w MBS) were administered to mice along with ...
INHIBITION STUDIES OF TERPENE BASED NATURAL PRODUCTS WITH CYCLIN-DEPENDENT KINASE 4 (CDK4 MIMIC CDK2)
Cyclin dependent kinases (CDKs) are known as cell cycle regulators in eukaryotic cell cycle. Different CDKs (CDK2, CDK4 etc.) are having structure homology among them. Using computer based molecular modeling tools, interactions between naturally occurring terpene based compounds with crystal structure of CDK4 mimic CDK2 enzyme having PDB ID : 1GII. Using In-silico techniques, the binding energies ...
PROTECTIVE EFFECTS OF FERULIC ACID AGAINST LIVER CHOLESTASIS INDUCED BY ETHINYLESTRADIOL IN ADULT FEMALE RATS
The aim of the present article was to examine the protective effect of ferulic acid against liver cholestasis in female rats treated with ethinylestradiol (EE). The daily oral administration of the ferulic acid at a concentration of 40 mg/kg body weight for 15 days to rats treated with EE (100 µg/kg body weight for 5 days) resulted in a significant protection against EE-induced decrease in plasma...
Since 1982, Wnt1 (Wingless int-1) was first identified in mammary carcinoma. Further, Wnt signaling pathway was discovered. Wnt signals were involved in stem cells development, regeneration, cell cycle and repair mechanism. Finally abnormality Wnt signals were stimulated variety of cancers. Especially, non-canonical signaling pathways such as Wnt/PCP and Wnt/Ca2+ pathway were involved in developme...
The occurrence of non-alcoholic fatty liver disease (NAFLD) is around 20-30% in the general population. NAFLD is usually asymptomatic, although a minority of patients may present with evidence of progressive liver injury with complications of cirrhosis, liver failure, and hepatocellular carcinoma. In spite of being common and potentially serious, relatively little is known about the natural histor...
SYNTHESIS AND CHARACTERIZATION OF TRANSITION METAL COMPLEXES OF N’-[(2Z, 3E)-3-(HYDROXYIMINO) BUTAN-2-YLIDENE] BENZOHYDRAZIDE
Synthesis and characterization of Co(II), Ni(II), Cu(II) and Pd(II) complexes of ligand N'-[(2Z,3E)-3-(hydroxyimino) butan-2-ylidene] benzohydrazide are reported. The ligand is monobasic and bidentate in nature. The molar conductivities reveal that all the metal complexes are non-electrolyte. The metal complexes have been characterized on the basis of spectral and magnetic studies. Co(II) ion form...
Ofloxacin is a fluoroquinolone antibiotic considered to be a second-generation fluoroquinolone. Ofloxacin is administered by oral, intravenous or topical (eye and ear drop) route. It is used as antibacterial for the treatment of various diseases like chronic bronchitis, pneumonia, urethritis, cervicitis, urinary tract infections, prostatitis, uncomplicated urethral and cervical gonorrhea. Ofloxaci...
“Soda” is one of the humors in the body which should be in normal level for being healthy. If “soda” increases in the body, some undesirable symptoms appear. In order to eliminate the excess “soda”, at first it should be maturated. There are different formulations in Iranian traditional medicine references as “Monzig-e-soda” which is a way of maturation of black bile. In one of the...
Standartizated plants extracts are new opportunity in addition with standard therapy. Hawthorn extract, Tribulus terrestris extract and magnesium gluconate are forming well balanced nutritional supplement that could benefits people with cardiovascular diseases and diabetes. All three substances are well known in the common herbal medicine in our country and abroad. Their mechanisms’ of actions i...
Aim of study: In this study, we investigate the potential effect of Nyctanthes arbortristis leaf extract in experimentally induced asthma in rats. The leaf has shown the prominent effect against the inflammation. Materials and methods: Asthma was induced experimentally in rats using Sephadex and in another model croton oil was applied on ear of rats; this model also mimics the biological event ...