Volume 1 (2010) - Issue 3, March
OCULAR DRUG DELIVERY: A REVIEW
The route of choice for the treatment of ophthalmic diseases is by the topical route because of the blood ocular barrier. The most commonly utilized conventional preparations of ophthalmic dosage forms are the solutions, suspensions and ointments which are relatively inefficient as therapeutic systems. Following administration, a large proportion of the topically applied drug is immediately dilute...
TRANSFERSOMES ULTRA FLEXIBLE VESICLES FOR TRANSDERMAL DELIVERY
Molecules greater than 500 Da normally do not cross the skin. This prevents epicutaneous delivery of the high molecular weight therapeutics as well as non-invasive transcutaneous immunisation. Transfersomes are a form of elastic or deformable vesicle, which were first introduced in the early 1990s. Elasticity is generated by incorporation of an edge activator in the lipid bilayer structure. The or...
PHYTOCHEMICAL AND PHARMACOLOGICAL POTENTIAL OF NERIUM OLEANDER: A REVIEW
Nerium oleander L. is an important medicinal material in Chinese folk medicine. In early times it is assumed that all parts of the oleander plant are poisonous to humans, animals and certain insects but now a day's numbers of pharmacological activities are determined by different scientists. Its main active constituents are polysaccharides, cardenolides, glycosides, and triterpenoids. The importan...
PROLONG RELEASE BIOADHESIVE VAGINAL FILM OF ANTI-HIV DRUG (ZIDOVUDINE): FORMULATION AND IN- VITRO EVALUATION
The present study concerned with the development and characterization of bioadhesive vaginal film (VF). Zidovudine containing VF were prepared by solvent casting method using different ratios of Acrycoat S 100 (AC) or Ethyl cellulose (EC) to Hydroxy propyl methyl cellulose (HPMC) and di butyl phthalate(DBP) as a plasticizer. The optimized films were found to be transparent, flexible and soft and e...
FORMULATION AND CHARACTERIZATION OF GASTRORETENTIVE FLOATING MICROBALLOONS OF METFORMIN
Gastroretentive dosage forms have potential for use as controlled drug delivery systems. Multiple unit systems avoid the “all-or-none” gastric emptying nature of single unit system. A controlled release system designed to increase its residence time in the stomach without contact with the mucosa was achieved through the preparation of floating microballoons by the emulsion solvent diffusion te...
U.V SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF MESALAZINE IN BULK AND ITS PHARMACEUTICAL DOSAGE FORMS
Mesalazine is used, either orally or rectally, as an anti-inflammatory agent in treating ulcerative colitis and, to a lesser extent, Crohn's disease. Mesalazine is a white to pinkish crystalline powder. It is slightly soluble in cold water and alcohol; more soluble in hot water, soluble in hydrochloric acid. A simple UV spectrophotometric method was developed for the determination of Mesalazine (M...
STUDIES ON WOUND HEALING ACTIVITY OF GEL FORMULATION CONTAINING COW GHEE AND ALOE VERA
ABSTRACT The present study aims to evaluate the wound healing activity of gel containing cow ghee and aloe vera in rats. Incision wounds for tensile strength and excision wounds contraction along with the histopathological examination of the regenerated tissues were employed to investigate the wound healing potential. Topical application of the test formulation alone promoted the tensile streng...
EFFECT OF NATURAL ALMOND GUM AS A BINDER IN THE FORMULATION OF DICLOFENAC SODIUM TABLETS
The present study was undertaken to find out the potential of gum from Almond gum to act as a binder and release retardant in tablet formulations. No significant work has been reported to use it as a tablet binder. The effect of almond gum and pvp on the release of diclofenac sodium was studied. The FT-IR spectroscopic studies of drug, gum and mixture indicated no chemical interaction. Seven formu...
ANTI-DEPRESSANT POTENTIAL OF MUSIC THERAPY
Depression should be recognized as a clinical syndrome that is characterised by a cluster of emotional, behavioural, and cognitive features. The prevalence of depression is consistently high worldwide, and is associated with considerable morbidity. Music is one of the oldest and most basic socio-cognitive domains of the human species. Music Therapy is growing as a profession globally, both in quan...
EVALUATION OF ANTHELMINTIC ACTIVITY OF LEAF EXTRACTS OF BUTEA MONOSPERMA
Butea monosperma (Fabaceae) is distributed all over India and has been used by triable as well a local people widely. Locally it is known as “Markundi” and a cool infusion of the flowers is taken in the treatment of diabetes among the Sahariya of Northwest M.P. Butea monosperma is used in the treatment of leprosy, gout, diarrhea, anti-inflammatory, diuretic and leucorrhoea. In the present work...
ISOLATION OF ACAULOSPORA SPECIES FROM JATROPHA CURCAS L AND PONGAMIA PINNATA PIERRE
Jatropha curcas L. and P. pinnata Pierre is gaining importance as biodiesel crop in India. Jatropha curcas L. a member of the family Euphorbiacea and Pongamia pinnata, a member of the family Leguminoseae. A study was conducted to identify common arbuscular mycorrhizal fungi present in its rhizosphere from different regions of India viz., Jodhpur (Rajasthan), Hissar (Haryana), Jhansi and Lalitpur (...
HYPOGLYCAEMIC EFFECTS OF METHANOLIC EXTRACT OF ANTHOCEPHALUS CADAMBA BARK IN ALLOXAN INDUCED DIABETIC RATS (ROX B) MIQ.
In view of the ethanobotanical and traditional claims of Anthocephalus cadamba plant used as hypoglycemic agent and wide use of its bark, fruits and leaf extract in anti-diabetic activity. Methanolic extract of Anthocephalus cadamba bark in alloxan induce hypoglycemia in rats. In glucose loaded normal rats, hypoglycemia was observed maximum at 120 minutes after administration of ACBE (Anthocephalu...