ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS DETERMINATION OF ZALTOPROFEN AND PARACETAMOL IN THEIR COMBINED SOLID DOSAGE FORM BYRP-HPLC METHOD
A simple, sensitive, linear, precise and accurate RP-HPLC method for simultaneous estimation of Zaltoprofen and Paracetamol in bulk and tablet formulation was developed and validated. The proposed RP-HPLC method utilizes Phenomenex C18 column (150 ×4.6 mm i.d., 5 µm), optimum mobile phase consisted of isocratic run of Phosphate buffer (pH-4.2): acetonitrile (40:60V/V) with the effluent flow rate...
Natural steroids, the simple mention of the word brings up topics like cheating, unfair advantages. The first misconception is that all steroids are used for muscle building. This is not at all the case, steroids are natural substances with many different effects in the human body, which begin over several days, as even birth control pills are a form of steroids. “Natural Steroids”, are the or...
The current pandemic of the novel coronavirus (SARS-CoV-2) termed as COVID-19 is the third recorded blowback of an animal coronavirus to a human being in the last twenty years. The pandemic is originated from China and currently impacted more than 205 countries worldwide (as on dated 2nd April 2020). This pandemic is not only affecting human life but also has questioned the worldwide status of hea...
Preservatives prolong the shelf-life of food, cosmetics and pharmaceuticals by preventing their spoilage. Antimicrobials such as nitrites, nitrates, benzoates and sulfur dioxide destroy or delay the growth of bacteria, yeast and molds. Anti-oxidants such as butylated hydroxy toluene (BHT), butylated hydroxy anisole (BHA), and propyl gallate slow or stop the breakdown of fats and oils. Anti-enzyma...
UV-VISIBLE SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION OF ASSAY OF PARACETAMOL TABLET FORMULATION
A novel, safe and sensitive method of spectrophotometric estimation in UV-region has been developed for the assay of paracetamol in its tablet formulation. The method have been developed and validated for the assay of paracetamol using Methanol and water as diluents. Which does not shows any interference in spectrophotometric estimations. All the parameters of the analysis were chosen according to...
When designing small molecules to interact with the targets, one should consider stereo selectivity. As considerations for exploring structure space evolve, chirality is increasingly important. Binding affinity for a chiral drug can differ for diastereomers and between enantiomers. For the virtual screening and computational design stage of drug development, this problem can be compounded by incom...
Aim: To evaluate safety and efficacy of diclofenac 75 mg/1ml (Dynapar AQ) administered as IV bolus versus diclofenac 75mg/3ml administered as IV infusion in patients with postoperative pain. Methods: 350 postoperative adult patientswere randomized to receive either treatment. Primary efficacy endpoints were time to onset of analgesia and postoperative pain intensity while secondary efficacy end...
Bryophyllum pinnatum is widely used in ayurvedic system of medicine as astringent, analgesic, carminative and also useful in diarrhoea and vomiting. It is naturalized throughout the hot and moist parts of India. The leaves of B. pinnatum have a variety of uses in the traditional system of medicine in India. They are eaten for diabetes, diuresis, dissolving kidney stones, respiratory tract infect...
The use of herbal drugs for the prevention and treatment of various health ailments has been in practice from time immemorial. Acacia arabica has been reported to be effective against a variety of disease including diabetes, skin disease and most concerning with cancer. The fresh plants parts of Acacia arabica is considered as astringent, demulcent, aphrodisiac, anthelmintic, antimicrobial, anti...
PHYTOCHEMICAL CONSTITUENTS OF ALOE VERA AND THEIR MULTIFUNCTIONAL PROPERTIES: A COMPREHENSIVE REVIEW
Aloe vera belongs to the family Liliaceae commonly known as Ghrit Kumari, is the ever known oldest and the most applied medicinal plant worldwide. Aloe Vera is used for vigor, wellness and medicinal purposes since rigvedic times. Health benefits of Aloe vera include its application in wound healing, treating burns, minimizing frost bite damage, protection against skin damage from x-rays, lung can...