Most Cited
| Year | 2020 | 2021 | 2022 | Total |
|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 548 | 2053 |
| Citations | 699 | 263 | 21 | 983 |
| Projected Impact Factor | 3.76 | 2 | 0.64 |
MIR AND NIR SPECTROSCOPY AS RAPID METHOD TO QUANTIFY MOLSIDOMIN IN GENERIC TABLET
This work investigates the potential of Partial Least Square (PLS) regression using two vibrational spectroscopies as mid infrared (MIR) and near infrared (NIR) spectroscopies for the quantification of molsidomin in tablets. Two very simple, rapid, inexpensive and green strategies were applied for this determination. Powder blends containing molsidomin and excipients were prepared. The excipients ...
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IN SILICO EPITOPE PREDICTION AND HOMOLOGY MODELING OF ENVELOPE SURFACE GLYCOPROTEIN GP160, PRECURSOR REGION FROM HUMAN IMMUNO DEFICIENCY VIRUS -1
The development of a highly effective AIDS vaccine will depend on the success of designing immunogens that will elicit immune response against broadly neutralizing antibodies to naturally circulating strains of HIV- can be done by reverse vaccinology. Reverse vaccinology is a good approach for provoking the broadly neutralizing antibody response by identifying the specific epitopes i.e. surface pr...
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ANGIOGENESIS AND CANCER THERAPY
Cancer spreads by metastasis which is the ability of cancer cells to penetrate into lymphatic and blood vessels, circulate through the bloodstream, and then invade and grow in normal tissues elsewhere. It is this ability to spread to other tissues and organs that makes cancer a potentially life-threatening disease. Cancer researchers involve in the study of the conditions necessary for cancer meta...
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SELF EMULSIFYING DRUG DELIVERY SYSTEM: A REVIEW
Solubility of orally administered drug is major challenge of pharmaceutical industry as nearly 35-40% of newly launched drugs possess low aqueous solubility which leads to their poor dissolution and low bioavailability, resulting in high intra & inter subject variability & lack of dose proportionality. This can be increased by different methods like salt formation, solid dispersion and com...
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LIPID BASED PARENTERAL DRUG DELIVERY SYSTEM
Lipid-based drug delivery systems in the form of triglyceride emulsions, micellar systems and liposomes have been used for parenteral administration for the last few decades. Large number of new chemical entities (NCE) presents formulation and bioavailability problems because of the dose and poor solubility in solvent and co-solvent systems. In addition, high drug concentrations can lead to irrita...
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PATHOPHYSIOLOGY OF NEUROPATHIC PAIN: A SYSTEMIC REVIEW
Neuropathic pain is considered as an inappropriate response caused by a lesion or dysfunction in the PNS or CNS). Neuropathic pain can manifest itself as either without a stimulus (stimulus-independent pain) and/ or as pain hypersensitivity elicited after a stimulus (stimulus-evoked pain). Stimulus-independent pain includes symptoms described by the patient such as (a) continuous, burning pain (b)...
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NEW INSIGHTS INTO LATENT TUBERCULOSIS: A PERSISTING GLOBAL HEALTH CHALLENGE
After more than a century, tuberculosis (TB) is still a formidable public health challenge as it contributes considerably to illness and death worldwide, irrespective of continuous advancement in technology and in depth understanding of molecular biology concepts. Mycobacterium tuberculosis persist for longer period in human and animal host in latent state without causing active disease and may re...
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ELECTROCHEMICAL STUDY OF INTERACTION OF THE HEAVY METAL IONS IN HYDROXYLATION REACTION OF SALICYLIC ACID ON GLASSY CARBON ELECTRODE
The formation of free hydroxyl radical (˙OH) in oxygen transfers at GCE and the reaction between the electrochemically produced ˙OH and salicylic acid (SA) is studied by cyclic voltammetry method. Experiments showed that ˙OH is formed in the potential range of 1.0-1.4V corresponding to the anodic discharge of H2O at the GCE. The interaction of Cu2+, Hg2+, Cd2+, Mn2+ ions on the hydroxylation re...
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VIRTUAL SCREENING OF NOVEL HIV-RT NNRT INHIBITORS USING ZINC DATABASE
Non-nucleoside reverse transcriptase inhibitors (NNRTI) are a group of small hydrophobic compounds with diverse structure that specifically inhibit HIV-1 reverse transcriptase (RT) by allosteric bind to change its conformation. NNRTIs interact with HIV-1 RT by binding to a single site on the p66 subunit of the p66/p51 heterodimeric enzyme, termed the NNRTI-binding pocket (NNRTI-BP), binding intera...
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IN VITRO ANTI-INFLAMMATORY ACTIVITY OF VARIOUS EXTRACTS OF LEAF AND BARK OF HOLOPTELIA INTEGRIFOLIA PLANCH
The different extracts of leaf and bark of the plant Holoptelia integrifolia were investigated for in-vitro anti-inflammatory activity by human red blood cell membrane stabilization (HRBC) method. The HRBC membrane stabilization activity of the petroleum ether extract of leaf at the concentration of 200 mg/ml showed 68.12+/-1.05 % and petroleum ether extract of bark at the concentration of...
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