Background: In present study, we aim to assess the anticandidal activity of crude extracts and screening of bioactive compounds and their identification by NMR, IR and GC-MS. Results: A total of 192 isolates were isolated from patients having oral and vaginal candidiasis and a total of 134 isolates showed positive results with Gram staining. The selected isolates APKU-2, APKU-3 and APKU-4 were ide...
SPECTROPHOTOMETRIC DETERMINATION OF DRUGS & PHARMACEUTICALS USING N-BROMOSUCCINIMIDE AND RHODAMINE-B COUPLE
Simple, sensitive, and accurate spectrophotometry method one each for estimation of five drugs viz., chloroquine phosphate (CHP), granisetron hydrochloride (GRA), rizatriptan benzoate (RIZ), zoledronic acid (ZOL) and zolmitriptan (ZOT), have been developed. The method depends upon oxidation of each drug by excess N-Bromo succinimide (NS), and subsequent determination of UN reacted NBS by Rhodami...
The most well-known widely used route of administration among all the routes that have been explored for the systemic delivery of drugs is oral drug delivery. Drugs can be delivered in a controlled pattern over a long period of time by the controlled or modified release drug delivery systems. The osmotic-controlled release oral delivery system, OROS, is an advanced drug delivery technology that us...
COMPARATIVE ANALYSIS OF PHYTOCHEMICAL CONSTITUENTS, FREE RADICAL SCAVENGING ACTIVITY AND GC-MS ANALYSIS OF LEAF AND FLOWER EXTRACT OF TITHONIA DIVERSIFOLIA (HEMSL.) A. GRAY
The secondary plant metabolites possess therapeutic value, thus play a significant role in human health and general wellbeing. The present study aimed to estimate the secondary metabolite concentration and to evaluate the antioxidant potential of Tithonia diversifolia leaf and flower extract in methanol. The phytochemical compounds in the extracts were characterized through Gas Chromatography-Mass...
Medicinal plants are a potential source of therapeutic drugs and play a central role in the health care system throughout the world. Plants have been an integral part of the life of many indigenous communities. Snakebite is a neglected tropical disease. Snakebite remains a major health concern throughout the world, especially in India. The highest Morbidity and Mortality occurs in rural and tribal...
Introduction: Reactive oxygen species and nitric oxide play a major role in the physiopathology of inflammatory diseases, neurodegenerative disorders, autoimmune pathologies and immunodeficiency. With this understanding targeting oxidative stress could be a promising approach in new drug discovery. Methodology: Therefore, new compounds that were isolated from methanolic extract of leaves of wild s...
Wear particle evoked lysis limits the long-run survivorship of total joint replacement (TJR) in polygenic disease. Monocyte / macrophages area the key cells of this adverse reaction. The aim of this study was to come up with useful human osteoclasts (OCs) in-vitro from sort a pair of diabetes (T2D) and health management to research the potential osteoclastogenic role of T2D and implant detritus in...
EFFECT OF FUROSEMIDE (LOOP DIURETIC) ON INGESTIVE BEHAVIOR, BODY WEIGHT AND CERTAIN HEMATOLOGICAL PARAMETERS IN ADULT WISTAR RATS
The present experiment was aimed to examine the effect of furosemide (loop diuretic) on ingestive behavior & some hematological parameters. The adult Wistar rats (n=6/ group) were divided into control group (n =6; Group I) and experimental group (n =6; Group II). The experimental group received furosemide intraperitonially (40mg/kg BW) for a duration of 30 days. The control group of rats was...
Zika virus is transmitted to people through aedes mosquito bites. People with Zika virus disease usually have symptoms of mild fever, exanthema (skin rash), joint pain and conjunctivitis that normally last for 2-7 days. There is no specific treatment or vaccine currently available. The best form of prevention is protection against mosquito bites. The virus is known to circulate in Africa, the Amer...
ISOLATION AND CHARACTERIZATION OF SOME PHYTOCHEMICAL COMPOUNDS FROM THE METHANOLIC EXTRACT OF SOLANUM TORVUM SWARTZ FRUITS
Solanum torvum Sw. belonging to the family Solanaceae is locally called as pea eggplant, sundai and cherry egg-plant in India. The fruits of Solanum torvum Sw. used to cure diseases of the diuretic, malaria, stomach aches, problems with the spleen, treat coughs, improve the eyesight, treats headaches which attribute many properties in Ayurveda, siddha, unani and local health traditions. The purpos...