Most Cited
| Year | 2020 | 2021 | 2022 | Total |
|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 548 | 2053 |
| Citations | 699 | 263 | 21 | 983 |
| Projected Impact Factor | 3.76 | 2 | 0.64 |
THE CLINICOPATHOLOGICAL PROFILE IN PATIENTS WITH EPITHELIAL OVARIAN CARCINOMA
The malignant tumors of ovary are a group of disease with varying clinical and biological behavior. It is fifth leading cause of death from cancer in women and the leading cause of death from gynecological cancer. This retrospective study has been undertaken to analyze patients of epithelial ovarian cancers. These cases were analyzed for various features like age, stage at presentation, histologic...
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COMPARATIVE ANALYSIS OF DRUG-INDUCED PARKINSONISM LIKE BEHAVIORS IN C57BL6 BLACK MICE USING A FORCE PLATE ACTIMETER.
This study aims to compare the Parkinsonism behavior induced by two drugs: Tacrine (9-amino-1,2,3,4-tetrahydroaminoacridine hydrochloride hydrate and MPTP (1-methyl, 4-phenyl 1,2,3,6 tetrahydropyrolidine) using a Force Plate Actimeter (FPA). 25 C57BL/6 black mice were equally divided into two groups for 5mg/kg tacrine and 30mg/kg MPTP experiment. Both groups contained sham, 5mg/kg tacrine or 30mg/...
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SATURATION SOLUBILITY OF SCOPOLAMINE IN THIN FILMS OF POLYACRYLATE PRESSURE SENSITIVE ADHESIVES IS TEMPERATURE DEPENDENT
The method of drug uptake from solid solution has been used to measure the saturation solubility of scopolamine base in various pressure sensitive adhesive DURO-TAKs at elevated temperature. The saturation solubility was strongly temperature dependent, being 50 – 100 % larger at 45°C than at 25°C. The higher temperature also caused much more rapid approach to equilibrium distribution of the dr...
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SYNTHESIS OF QUINOLINE DERIVATIVES BY REACTION OF DIMETHYL(2R,3S,4R)-2-PHENYL-4-(PHENYLAMINO)-1,3,4-TRIHYDROQUINOLINE-2,3-DICARBOXYLATE WITH SOME AMINES
In this work, quinoline derivatives were synthesized from reaction of aniline, benzylaldehyde and dimethylacetylene dicarboxylate (DMAD) in sequent steps to provide quinoline derivative dimethyl (2R, 3S, 4R)-2-phenyl-4-(phenylamino)-1, 3, 4-trihydroquinoline-2,3-dicarboxylate (12). Compound (12), was reacted with some amines such as hydrazine hydrate, urea, thiourea, ethylenediamine, diaminoprop...
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TOXICOLOGICAL CHRACTERIZATION OF BRHANMANJISTHADI KVATHA CURNA (BRH) ON THE BASIS OF TOTAL PROTEIN AND ALBUMIN CONTENT, LIPID PROFILE, LIVER FUNCTION, KIDNEY FUNCTION, SERUM URIC ACID AND ENZYMATIC PROPERTY IN RATS’ PLASMA AFTER CHRONIC ADMINISTRATION
Brhanmanjisthadi Kvatha Curna (BRH) an Ayurvedic preparation, is used as a traditional medicine in filariasis in the northern part of the country. After 45 consecutive days of chronic administration of the BRH preparation in rats its toxicological aspects was studied. In the study the total protein content in the plasma was increased (2.80 %) in BRH treated male rats in comparison to their control...
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A PILOT STUDY TO ASSESS THE EFFICACY AND SIDE EFFECTS OF SILYMARIN ALONE AND IN COMBINATION WITH ALENDRONATE IN TREATMENT OF POSTMENOPAUSAL OSTEOPOROSIS
Background: Currently oral bisphosphonates such as alendronate are the preferred therapeutic option for the treatment of postmenopausal osteoporosis by increasing bone mineral density and decreasing both vertebral and non-vertebral fracture risk. Silymarin is mainly used as hepato-protectant but in recent studies on ovariectomized rats, it was found that silymarin can be a promising antiosteoporot...
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3D-QSAR STUDY OF BENZOTHIAZOLE DERIVATIVES AS p56lck INHIBITORS
3D-QSAR models of Comparative of Molecular Field Analysis (CoMFA) and Comparative of Molecular Similarity Indices Analysis (CoMSIA) of 44 potent p56lck inhibitors were performed. The conventional ligand-based 3D-QSAR studies were performed for a series of Benzothiazole derivatives as p56lck inhibitors. The model gave q2 values of 0.710 and 0.642, r2 values of 0.966 and 0.956 for CoMFA and CoMSIA, ...
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ENHANCEMENT OF BIOAVAILABILITY OF NORFLOXACIN MUCOADHESIVE SUSPENSION BY USING DIFFERENT GRADES OF CARBOPOL
Norfloxacin is slightly soluble in water and is a synthetic antimicrobial fluoroquinolone. Absorption of Norfloxacin is slightly impaired when it is administered with food as evidenced by a reduction of approximately 30% in the peak serum concentration. In the present study concept of mucoadhesive suspension is introduced to overcome the limitation of drug that has poor oral bioavailability an...
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IDENTIFICATION AND QUANTIFICATION OF AN UNKNOWN PEAK IN RESIDUAL SOLVENT ANALYSIS BY GC USING RELATIVE RESPONSE FACTOR
Organic solvents are integral part of chemical synthesis in pharmaceutical industry. These are commonly used as reaction media, in separation, purification of synthetic products and also for cleaning of equipment. Some of the solvents degrade to other solvents or unknown impurity either during synthesis or in analytical conditions. In this study, we have investigated formation of a trace level imp...
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THE ROLE OF LAB-ON-A-CHIP DEVICE IN HEALTH CARE
Lab-on-a-chip (LOC), a scaled down microfluidic device for carrying out laboratory operations outside the scope of standard laboratories is a rather appealing development in the field of science and technology for the whole laboratory has been reduced to a small chip capable of carrying out various functions. Keeping to its word, micro, miniaturized volume samples and reagents has ebbed the time t...
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