Most Cited
| Year | 2020 | 2021 | 2022 | Total |
|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 548 | 2053 |
| Citations | 699 | 263 | 21 | 983 |
| Projected Impact Factor | 3.76 | 2 | 0.64 |
THE SUCCESS OF DIFFERENT APPROACHES TO THE DEVELOPMENT TO ANTIPLATELET DRUGS
The aim of this research is to precisely discuss and appraise the success of different approaches to the development to antiplatelet drugs. Platelets play a main function in haemostasis and the development of arterial thrombosis that is the final event complicating cardiovascular diseases and peripheral vascular diseases, and antiplatelet drugs improve survival of patients with these diseases. Ant...
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ASSOCIATION BETWEEN ATHEROGENIC RATIO TO FASTING PLASMA GLUCOSE AND HbA1c
Hyperlipidemia is a common finding in uncontrolled Diabetes Mellitus (DM) and patients with DM generally show alteration in lipid profile, notably in triglycerides value. Research done in the past has pointed out the usefulness of Atherogenic Index of Plasma (AIP) as a useful parameter for the diagnosis of Type 2 DM. HbA1c is well established as gold standard to monitor long term diabetic control....
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DEVELOPMENT OF RP-HPLC METHOD FOR THE ESTIMATION OF IN VITRO AND IN VIVO SAMPLES OF KETOPROFEN IN BULK DRUG AND TRANSDERMAL DOSAGE FORM
A simple and accurate Reverse Phase High Performance Liquid Chromatography (RP-HPLC) method has been developed for the estimation of ketoprofen in vitro samples and in vivo samples from bulk drug and from administered transdermal dosage form, using Spherosorb S5 ODS of 10cm X 4.6 mm column, (5μm particle size). Mobile phase for in vitro sample analysis and in vivo plasma samples consists of 0.01 ...
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A STUDY ON THE ROLE OF DIETARY AGENT MOMORDICA CHARANTIA L ON PROTEIN GLYCATION
Protein glycation is a spontaneous post translational modification of proteins by excess sugars causing formation of advanced glycation end products (AGEs) in diabetic individuals and responsible for diabetes complications. A wide variety of anti-glycating agents have been reported & recently there has been interest in natural products with anti-glycation properties. Momordica charantia L (M. ...
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EFFECT OF NUTRIENTS ON LIVER MARKER ENZYMES OF WISTAR RATS
A wide range of compounds are found to be effective against cancer for example Vitamin D3, lysine, proline, gallate, quercetin, etc. Glucosinolates from cabbage are secondary metabolites hydrolyzed by the enzyme myrosinase 1. Their breakdown products such as isothiocyanates, nitriles and thiocyanates, are chemically very reactive, and they are known for their bioactive characteristics, such as a...
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GOLD NANO-CONJUGATES: A LEAP IN CANCER TREATMENT
The use of nanoparticles as drug delivery and targeting agents has led to immense progress in the field of biomedicine and diagnostics. Likewise gold nanoparticles can be conjugated with various molecules, for instance, to plasmid DNA for gene therapy, to various drugs for antibacterial and anticancer properties, to several antibiotics and peptides for immunological and diagnostic purposes. The re...
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TEMPLATE SYNTHESIS AND CHARACTERIZATION OF LANTHANIDE(III) COMPLEXES OF 21-MEMBERED UNSYMMETRICAL PENTAAZA MACROCYCLIC SCHIFF BASES BEARING PENDANT ARM. IDENTICAL FRAME WORK: PART II
A series of discrete mononuclear lanthanide(III) complexes of H2L1 [Ln(H2L1)(NO3)2]NO3.nH2O (Ln = La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Y; n = 1 for Ce; n = 2 for La, Sm, Gd and Y; n = 3 for Pr, Nd, Eu, and Tb) have been prepared by the condensation of Schiff-bases with the precursor compounds namely, 2,6-diformyl-4-methylphenol, 1,5-diamino-3-azamethypentane and 4,5-dimethyl-1,2-phenylenediamin...
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MECHANISMS OF UROLOGIC COMPLICATIONS IN STREPTOZOTOCIN-INDUCED TYPE 1 DIABETES MELLITUS
Patients with DM are often afflicted by debilitating urologic complications. The main aim of this study is to investigate the effect of streptozotocin (STZ)-induced type I diabetes on contractile responses to numerous stimuli, intracellular cation concentrations and morphology in the rat. Adult rats (n=12) were humanely killed and detrusor muscles of urinary bladder located and excised rapidly a...
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A PRAGMATIC APPROACH ON COLONIC DELIVERY OF RIFAXIMIN USING POLYMER COATED MULTI-PARTICULATE SYSTEM
This study aimed to develop and optimize a multi-particulate formulation for colon targeted delivery of rifaximin by application of a functional coat of Eudragit L100 and Eudragit S100 mixture on the drug layered pellets. The rifaximin-excipients compatibility was confirmed with FTIR studies. Functional coat completely restricted drug release in pH 1.2 dissolution medium. Statistical optimizatio...
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AUGMENTATION OF TIL-CD3 IN ORAL CANCER: VARIATIONS IN RELATION TO STAGE AND GRADE OF DISEASE
Oral squamous cell carcinoma (OSCC) is often associated with a lymphocytic infiltrate that is believed to represent an in vivo immune reaction to the tumor cells. In this study, the tumor-infiltrating lymphocytes (TIL) associated with primary OSCC were characterized in hundred newly-diagnosed patients to determine the nature of the immune response to the primary tumor and to correlate it with stag...
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