Most Cited
| Year | 2020 | 2021 | 2022 | Total |
|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 548 | 2053 |
| Citations | 699 | 263 | 21 | 983 |
| Projected Impact Factor | 3.76 | 2 | 0.64 |
SYNTHESIS OF THE HETEROCYCLIC HYDROXAMIC ACID DERIVATIVES FOR PDF INHIBITORS AS A ANTIBIOTICS
Peptide deformylase (PDF) is a mononuclear metal ion protein that is responsible for removing the N-formyl group of nascent proteins found in bacteria and chloroplasts in order for them to become mature proteins. From literature it was found that heterocyclic derivatives containing hydroxamic acid and hydroxyl amine exhibit good antibacterial and PDF inhibitory activity. Heterocycles bearing nitro...
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EVALUATING ADJUNCTIVE ROLE OF PPI AS ANTI INFLAMMATORY AGENT IN KNEE OSTEOARTHARITIS: A PROSPECTIVE STUDY IN TERTIARY CARE HOSPITAL
Osteoarthritis (OA) is one of the main causes of disability worldwide. Patients are mostly treated with NSAIDS with PPI and H2 blockers, analgesics, opoids etc in everyday practice. In addition to anti-secretory effects, PPIs have anti-oxidant and anti-inflammatory actions in vitro. But the role of PPIs as anti-inflammatory agents remains to be explored. Aim: Present study was aimed to compare eff...
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COMPARISON OF ANALGESIC EFFECT OF EPIDURAL ROPIVACAINE (0.2%) AND ROPIVACAINE (0.2%) WITH FENTANYL (4mcg/ml) IN POST OPERATIVE PATIENT OF TOTAL KNEE REPLACEMENT SURGERY
Introduction: Epidural anesthesia is the most commonly used technique for providing not only peri-operative surgical anesthesia but post-operative analgesia in lower abdominal and limb surgeries. Our study aimed to assess the comparison between ropivacaine(Group A) and combination of ropivacaine with fentanyl (Group B) in terms of their analgesic effect, hemodynamic stability, side effects and req...
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ROLE OF DEFERASIROX, AN ORAL IRON CHELATOR IN PREVENTION OF ISCHEMIC REPERFUSION MYOCARDIAL INJURY IN ALBINO RABBITS
An experimental study was carried out after getting approval from institustional animal ethical committee to study the role of oral iron chelator, deferasirox in prevention of myocardial ischemic reperfusion injury in albino rabbits. Albino Rabbits of either sex were divided into two groups control (n=5) and test group (n=5), receiving deferasirox. Experiments were done using isolated heart perf...
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SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME QUINOLINE DERIVATIVES
Cyclocondensation of 5-6 and 7-8 with chloroacetyl chloride in presence of triethylamine give 9-10 and 11-12 respectively. All the synthesized compounds 1-12 have been screened for their antibacterial as well as antifungal activities and compared with reference drugs streptomycin and fusidic acid respectively. These synthesized compounds were screened for their antibacterial activity against S. ...
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SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL 1,8-NAPHTHYRIDINES CONTAINING PYRAZOLINONE, PYRAZOLE, ISOXAZOLINONE, ISOXAZOLE AND PYRIMIDINE-2-ONES
Diazonium salt of 2-(p-aminophenyl)-1,8-naphthyridine (I) was coupled with active methylene compounds to afford the hydrazono-1,8-napthyridinyl (III-V) and azo(VI) derivatives. Hydrazono ethyl acetoacetate (III) and ethyl cyanoacetate (IV) derivatives on treatment with hydrazine and substituted hydrazine’s were later reacted with hydroxylamine HCl in the presence of ethanol followed by cycliza...
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PROTECTIVE EFFECT OF “RAPHANUS SATIVUS” EXTRACT AGAINST COPPER SULPHATE TOXICITY IN “CTENOPHARYNGODON IDELLA” FISH
The living organisms of the aquatic ecosystem have been directly affected by the accumulation of the heavy metals in the aquatic environment 1. Fishes are very good biosensors of aquatic contaminants and as bio-indicator species respond with great sensitivity to changes in the aquatic environment. Copper will accumulate in many different organs in fish and mollusks. In the present study the acute ...
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ASSESSMENT OF VITAMIN D ON METABOLIC DISORDERS IN ARTHRITIC PREDIABETIC PATIENTS- A PHARMACOLOGICAL APPROACH
We planned to clarify the association between the Vitamin D supplementation and predisposition of metabolic syndrome including obesity, diabetes mellitus, hypertension and dyslipidemia in arthritic patient with pre diabetic condition and to assess prediabetes interfere in the disease progression. Retrospective observational study was conducted on 236 patients. Of these, Arthritis patients with no ...
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SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 3-(2′-HYDROXY-3′-NITRO-5′-METHYLPHENYL)-5-(ARYL/HETERYL) PYRAZOLES
Heterocyclic compounds are well known for their different biological activities like anti-inflammatory, antibacterial, antifungal, anticancer, insecticidal, pecticidal, antibiotic, etc. the versatile applications of oxygen, nitrogen and sulphur containing heterocyclic compounds have made this area of extensive research. The present study deals with the synthesis of some new 3-(2'-hydroxy-3'-nitro-...
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PHYSIOCHEMICAL MICROBIAL AND PHARMACOLOGICAL STUDIES OF Zn (II) – 6- THIGUANINE DRUG COMPLEX
A new complex has been synthesized of Zn (II) complex with 6-thioguanine and physicochemical characterized by amperometry, polarography elemental analysis, UV and IR spectroscopy. After Synthesis of metal complex, it was evaluated it for antibacterial activities against various pathogenic microorganisms such as; Streptococcus aureus, Proteus. M., klebsiella pneumonia and Asperginus Niger, Nigrospo...
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