Most Cited
| Year | 2020 | 2021 | 2022 | Total |
|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 548 | 2053 |
| Citations | 699 | 263 | 21 | 983 |
| Projected Impact Factor | 3.76 | 2 | 0.64 |
BIOEQUIVALENCE STUDY OF TWO BRANDS OF PHENYTOIN SODIUM 100MG FORMULATIONS IN HEALTHY ADULT MALE RABBITS
The objective of the study was to compare the bioavailability of a single oral 100 mg dose of two brands of phenytoin sodium formulations available in the Nepalese market. Formulation B was taken as test drug and compared with the innovator brand which was taken as reference standard. A randomized, two-way crossover study was done in six healthy adult male rabbits. All six rabbits received a singl...
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FORMULATION AND IN-VITRO EVALUATION OF ACECLOFENAC ORODISPERSIBLE TABLETS
The object of the study was to formulate and evaluate Aceclofenac orodispersible tablets (ODT) by wet granulation method using different super disintegrants in different concentrations. Orodispersible tablets produce rapid dissolution of drug and absorption thereby producing rapid onset of action. Five batches (AFD1, AFD2, AFD3, AFD4, AFD5) of Aceclofenac orodispersible tablets were prepared and c...
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FORMULATION AND IN-VITRO CHARACTERIZATION OF FLOATING TABLET OF ENALAPRIL MALEATE
The present study was aimed at developing an oral floating system for Enalapril maleate with the objective to enhance the oral bioavailability of the drug. As it is a prodrug, oxidizing agent KMnO4 was used with distilled water and observed at 340 nm against a reagent blank, using PC Shimazdu UV Spectrophotometer. The obtained standard graph of drug was a straight line with coefficient correla...
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EFFECT OF CO-ADMINISTRATION OF QUERCETIN ON GOAT INTESTINAL PERMEABILITY OF BERBERINE CHLORIDE
The purpose of the present study was to explore the effect of co-administration of bioenhancer quercetin on membrane permeability of poorly permeable berberine chloride, on goat intestinal membrane model. The effect of co-administration of quercetin was investigated at 2, 6, and 10 mg concentrations. The study revealed a beneficial effect of low concentration of quercetin on % cumulative drug rele...
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SIGNIFICANCE OF PHARMACEUTICAL FACTORS ON SELECTION OF BIOBATCH
Biobatch is usually prepared for the purpose of pharmacokinetic evaluation before NDA or IND filing. There are several critical issues that one has to face during the audit process like equivalence between the Biobatch and proposed commercial production batch. During the development and scale-up of the manufacturing process, various standard operating processes have to be documented to provide lin...
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PREPARATION AND DRUG RELEASE BEHAVIORS OF pH-SENSITIVE MICROCAPSULES
The pH-sensitive microcapsules were prepared by interfacial polymerization, in which caffeine was used as a model drug and hyperbranched poly L-lysine (HBPL) and terephthaloyl chloride as wall-forming materials. The microcapsules were characterized by Malvern particle size analysis, scanning electron microscopy, Fourier transforms infrared spectrophotometry (FTIR) and UV-vis spectrophotometer. Tri...
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DEVELOPMENT AND CHARACTERIZATION OF ORAL DISSOLVING FILM FOR PROMETHAZINE HCL
Promethazine hydrochloride, one of the most effective agents for treating motion sickness, mainly acts as a strong antagonist of H1 receptor (antihistamine) and it blocks the action of acetylcholine on the receptors (anticholinergic effect). The purpose of present work was a development of fast dissolving oral film of promethazine HCl to overcome the limitation of current routes of administration,...
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POSSIBLE MECHANISMS OF METABOLIC CHANGES OF BIOCHEMICAL METABOLISM IN THE CONDITIONS OF EXPERIMENTAL ALLOXAN-INDUCED DIABETES MELLITUS (DM)
Alloxan diabetes mellitus (DM) simulates acute metabolic stress in a different direction, whose starting point is primary lysis of β-cells in the pancreas. Disorders in the system of the major insulin-induced regulatory mechanism occur, initiating imbalance in the system of a living organism generally. Primary changes occur on the level of metabolic ways of the cells of the pancreas and liver: re...
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SCREENING OF 4-([1,3,4]OXADIAZINO[6,5-b] INDOLE-3-YL)ANILINE DERIVATIVES FOR ANTI-BACTERIAL ACTIVITY BY IN-SILICO AND IN-VITRO METHODS
Schiff bases of isatin are investigated overtime for their pharmaceutical properties and have been found to have various activities such as anti-viral, anti-bacterial, anti-inflammatory, analgesic, anti-HIV, anti-depressant, anti-convulsant, fungicidal, etc. Isatins are treated with hydrazine derivatives and cyclized by sulfuric acid. These compounds are alkylated by di alkyl aminoalkyl halides in...
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ACUTE AND 28-DAY REPEATED DOSE TOXICITY OF AVERRHOA CARAMBOLA LEAVES ETHANOLIC EXTRACT IN RODENTS
Averrhoa carambola -L. (Oxalidaceae) has great importance in the Indian traditional system of medicine for controlling diabetes and piles: the combined extracts of leaves as well as fruits of A. carambola are used for the treatment of jaundice, gastric problems and other chronic conditions as well as in food supplements.The objective underlying this experiment is to determine the safety profile of...
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