HYDROXYCHLOROQUINE (HCQ) AS AN EMERGING AND PROMISING DRUG CANDIDATE IN COVID-19 PANDEMIC – A SYSTEMATIC REVIEW
Hydroxychloroquine (HCQ) belongs to the class of 4-aminoquinolines. It is a hydroxylated version of chloroquine with a similar mechanism of action but rather a safe profile. It is primarily an antimalarial drug but has been extensively used for treating rheumatoid arthritis, porphyria, discoid and systemic lupus erythematosus as well. Most recently, this drug has found a place in the treatment of...
PRODUCTION OF EXTRACELLULAR CELLULASE USING BACILLUS SPECIES ISOLATED FROM RED SOIL AND OPTIMIZATION OF CELLULASE ACTIVITY
Enzymes plays a major role in industries like textile, leather, sugar, paper, rubber, tea etc., Microbes plays important role in enzyme production due to their fast growth rate, easy to manipulate for getting highly stable enzymes through genetic engineering and requires shorter time for production and purification steps. In our present study, we concentrated on the enzymes used in textile industr...
BIOSYNTHESIS AND CHARACTERIZATION OF GOLD NANOPARTICLES FROM CEIBA PENTANDRA (L.) GAERTN BARK AND EVALUATION OF ITS ANTIBACTERIAL AND ANTICANCER ACTIVITY
The present investigation was aimed at synthesis, characterization and in-vitro antibacterial and anticancer activities of synthesized gold nanoparticles using bark extract of Ceiba pentandra (L.) Gaertn. The synthesized AuNPs were confirmed by a UV-vis spectrometer through observing the surface plasmon resonance peak at 535 nm. Various other techniques, such as Fourier transform infrared spectros...
Helicobacter pylori is a major etiological agent responsible for several gastric diseases such as gastritis, peptic ulcer disease, and gastric cancer. From the last two decades, standard triple therapy is mostly recommended for H. pylori eradication; however, its efficacy is restricted by antibiotic resistance. Hence, the present study aimed at exploration for novel therapeutic agents being warran...
Averrhoa carambola -L. (Oxalidaceae) has great importance in the Indian traditional system of medicine for controlling diabetes and piles: the combined extracts of leaves as well as fruits of A. carambola are used for the treatment of jaundice, gastric problems and other chronic conditions as well as in food supplements.The objective underlying this experiment is to determine the safety profile of...
The aim of this study was to screen the presence of bioactive compounds through GC-MS analysis and carry out the ant-inflammatory test of the methanolic tissue extract of Murex tribulus, a spiny predatory gastropod that is widespread from the Central Indian Ocean to Western Pacific Ocean. The GC-MS analysis of the methanolic flesh extract revealed the presence of four bioactive compounds, 1, 2 dim...
The research was carried out to formulate and evaluate ophthalmic solutions of Ofloxacin with amino acid transporters and compare the transcorneal permeation of Oflaxacin with that of the standard. In the study three different eye drop formulations were prepared by conjugation of the drug with different amino acids such as Alanine, Glycine and Leucine by solvent evaporation technique, the extent o...
PHYTOCHEMICAL SCREENING, IN-VITRO EVALUATION OF ANTIOXIDANT AND ANTIBACTERIAL EFFICACY OF METHANOLIC LEAF EXTRACT OF CLINOPODIUM NEPETA (L.) KUNTZE
The objective of the present study is to evaluate the phytochemical constituents, antioxidant and antibacterial activities of methanolic leaf extract of Clinopodium nepeta (L.) Kuntze. Total phenolic content of leaf extracts was assessed using Folin-Ciocalteu and AlCl3 reagent. Antioxidant assays were evaluated using DPPH, ABTS radical scavenging, and ferric, reducing antioxidant power (FRAP) meth...
IDENTIFICATION OF AEROTOLERENCE GENE BATA AND BATB IN SUBGINGIVAL MICROFLORA: AGGREGATIBACTER ACTINOMYCETEMCOMITANS, TANNERELLA FORSYTHIA AND PREVOTELLA INTERMEDIA
Subgingival obligate anaerobes present within the biofilm such as Porphyromonas gingivalis, Tannerella forsythia, Prevotella intermedia and Aggregati bacter actinomycetemcomitans have been implicated in the initiation and progression of periodontal disease. Recent documentation has demonstrated that P.gingivalis is capable of maintaining its viability when exposed to oxidative stress by expressing...
SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL METHYLPYRIMIDINE DERIVATIVES AS AN ANTIDIABETIC AND ANTIHYPERLIPIDEMIC AGENTS
Diabetes and hyperlipidemia become a major risk factor for cardiovascular diseases in the world. Hyperlipidemia is a relatively common problem in patients with poorly controlled diabetes. In searching for a new class of antidiabetic and antihyperlipidemic agents, many compounds with pyridine moiety have been found to possess good activity against diabetes and hyperlipidemia. The present study was ...