Most Cited
| Year | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total |
|---|---|---|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 549 | 628 | 408 | 376 | 3466 |
| Citations | 2186 | 1048 | 351 | 329 | 66 | 6 | 3986 |
| Projected Impact Factor | 6.64 | 4.43 | 2.15 | 1.07 | 0.58 | 0.38 |
EXERCISE-INDUCED OXIDATIVE STRESS MANAGEMENT BY METHANOLIC EXTRACT OF ZINGIBER OFFICINALIS ON SOME VITAL TISSUES IN MALE RAT
Background: Zingiber officinalis known as ginger, under the family Zingiberaceae, is a popular food spice and occupies an important place in Ayurvedic and traditional medicine. Its rhizome is used as antioxidative, carminative and for chronic diseases. Aims: Study indicated the curative effects of methanolic extract of ginger on severe exercise-induced oxidative damage in vital organs. Materials a...
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A MODIFIED EFFICIENT METHOD FOR ISOLATION OF RHEIN FROM CASSIA ANGUSTIFOLIA (SENNA)
Chemically, rhein is 9, 10-Dihydro-4, 5-dihydroxy-9, 10-dioxo-2-anthracenecarboxylic acid, and use as an intermediate to synthesize diacerein which widely used in the treatment of degenerative diseases like, osteoarthritis, osteoporosis, and rheumatoid arthritis and hence has commercial importance. Rhein occurs in free state in nature in different plant families like Cassia, Rhamnus, and Rheum but...
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ASSESSMENT OF ANTIBACTERIAL AND ANTIOXIDANT ACTIVITY OF WHEY PROTEIN AND QUANTIFICATION BY REVERSE PHASE HPLC
Dairy and milk consumption are habitually included as important essentials in a healthy and balanced diet. It is the principal food for mammals and provides all the essential energy and nutrients to guarantee proper growth and development. Whey protein present in the milk is quickly digested and therefore amino acids are delivered quickly to muscles to help start the muscle-building process. The m...
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CASE REPORT OF RELAPSE ACUTE LYMPHOBLASTIC LEUKAEMIA (ALL) -A DIAGNOSTIC DILEMMA
Acute lymphoblastic leukaemia (ALL) of the B-cell lineage (B-ALL) is a malignant neoplasm identified by the accumulation of immature lymphoid progenitor cells in bone marrow and blood. Numerous chromosomal aberrations have been found to be correlated with disease, relapse and its clinical outcome. The survival and cure rate has been improved drastically with the advent of modern methods of diagnos...
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FORMULATION AND EVALUATION OF MATRIX DIFFUSION CONTROLLED TRANSDERMAL DRUG DELIVERY OF HYDRALAZINE HYDROCHLORIDE FOR THE TREATMENT OF HYPERTENSION
In the present study novel matrix diffusion controlled transdermal patches of Hydralazine hydrochloride, a hypertensive drug to ensure satisfactory drug release were successfully prepared by solvent casting method with optimization of suitable polymeric blend of Eudragit L100 (EL-100), ethyl cellulose (EC), polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), carbopol, hydroxypropyl cellulose (HPC...
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ANTI-INFLAMMATORY, IN-SILICO DOCKING AND ADME ANALYSIS OF SOME ISOLATED COMPOUNDS OF TAGETES ERECTA FLOWER HEADS
Inflammation is a normal, protective response to tissue injury caused by physical trauma, noxious chemicals or microbiological agents. Medicinal plants and their secondary metabolites are progressively used in the treatment of diseases as complementary medicine. In the present study methanolic extract of flower heads of Tagetes erecta was screened for its phytochemical constituents and then subjec...
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DEVELOPMENT AND VALIDATION OF GAS CHROMATOGRAPHY METHOD FOR THE DETERMINATION OF GENOTOXIC IMPURITY, EPICHLOROHYDRIN, IN LINEZOLID DRUG
A sensitive and robust gas chromatography with a flame ionization detector method was developed for the quantification of epichlorohydrin in the linezolid drug substance and validated using guidelines as mentioned in ICH Q2 (R1). Epichlorohydrin was separated on CP-Volamine stationary phase (length 60 m, diameter 0.32 mm, particle size 5 µ) in linear thermal programming using dichloromethane as a...
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DEVELOPMENT OF A LIQUID ORAL IN-SITU GEL OF VORICONAZOLE FOR SUSTAINED RELEASE AND ENHANCED BIOAVAILABILITY: EQUIVALENCE TESTING USING EARTH MOVER’S DISTANCE
Development of a sustained release liquid oral in-situ gel of Voriconazole with improved bioavailability has been the main aim of this project. Complexation of the drug with hydroxypropyl beta-cyclodextrin was done to improve the solubility and stability of the drug. The mucoadhesive polymer carbopol 934P and release retardant HPMC E50 were used as factors and a two-square factorial design was emp...
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SALUTARY ACTIVITY OF BERBERINE AGAINST DIBUTYLTIN DICHLORIDE INDUCED ACUTE PANCREATITIS IN ALBINO WISTAR RATS
Background: Berberine is a natural alkaloid used as traditional Chinese medicine. Objective: The objective of the present study was to evaluate the effect of berberine on dibutyltin dichloride (DBTC) induced acute pancreatitis in albino Wistar rats. Methods: In this study 24 Wistar rats were randomly selected and divided into four groups. Each group consists of 6 animals. Group-1 (-ve control), Gr...
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FORMULATION AND CHARACTERIZATION OF SILVER NANOPARTICLE COATED WITH NATURAL pH STIMULI POLYMER
Carboplatin is the first-line choice of drug for ovarian cancer. In this investigation, we have prepared carboplatin silver nanoparticles (CSNP’s) by electrostatic adsorption. The size range was found to be 53-87 nm and the zeta potential was in the range of -36 to -61. After coating with hyaluronic acid and drug the size was observed to be around 80 nm and zeta potential was -41. After coating ...
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