THE SYNTHESIS OF QUINAZOLON-1,3,4-OXADIAZOLE ANALOGUES AND STUDIES OF THEIR ANTIMICROBIAL AND ANTIOXIDANT ACTIVITY
A series of conjugation of two heterocycles 1, 3, 4-oxadiazole and quinazolone were synthesized and screened for antimicrobial as well as antioxidant activity. Compound4-(4-oxo-2-phenyl-quinazoline-3(4H)-yl)-benzohydrazide 3 on cyclization with different aromatic acids in the presence of phosphoryl chloride (POCl3) give different 1, 3, 4-oxadiazole derivatives. Similarly, compound 3 on reaction wi...
ELECTROCHEMICAL STUDY OF INTERACTION OF THE HEAVY METAL IONS IN HYDROXYLATION REACTION OF SALICYLIC ACID ON GLASSY CARBON ELECTRODE
The formation of free hydroxyl radical (˙OH) in oxygen transfers at GCE and the reaction between the electrochemically produced ˙OH and salicylic acid (SA) is studied by cyclic voltammetry method. Experiments showed that ˙OH is formed in the potential range of 1.0-1.4V corresponding to the anodic discharge of H2O at the GCE. The interaction of Cu2+, Hg2+, Cd2+, Mn2+ ions on the hydroxylation re...
FORMULATION DEVELOPMENT AND IN-VITRO CHARACTERIZATION OF FAST DISSOLVING POLYMERIC FILMS OF OLANZAPINE FOR THE MANAGEMENT OF PANIC ATTACK OF SCHIZOPHRENIA
Schizophrenia is a severe and disabling disorder which needs immediate administration of a suitable drug. Olanzapine, a BCS class II atypical antipsychotics drug of thienobenzodiazepine class is frequently prescribed to treat schizophrenia. The aim of the present investigation was to formulate mouth dissolving films of Olanzapine to improve its solubility and patient compliance. An inclusion compl...
Mucositis is a foremost acute complication in the clinical setting, occurring in a large percentage of patients undergoing cytotoxic therapy. One of the major problems with mucositis is that the underlying mechanisms behind its development are not wholly understood, which makes it extremely difficult to develop effective interventions. Animal models provide a critical source of knowledge when samp...
SELF RATED SYMPTOM MEASURE OF VARIOUS MENTAL HEALTH DOMAINS OF UNDERGRADUATE MEDICAL STUDENTS OF TERTIARY CARE TEACHING HOSPITAL
Introduction: Mental disorders account for nearly 12% of the global burden of disease. They are expected to become the second most important cause of disability in the near future. Medical students remain under great academic pressure to pass internal and external exams which continuously keep them under pressure. It is also very important to know how students feel rather than to treat only those ...
ASSESSMENT OF PATIENT SATISFACTION: A STUDY OF CORE AND SECONDARY ATTRIBUTES OF HOSPITAL HEALTHCARE SERVICES
This research evaluates patient satisfaction with the core and secondary attributes of hospital healthcare service, using two conventional methods, stated and derived importance explaining pros and cons related to each method. The study shows the significance of some of the core attributes and secondary attributes are recoverable equally well, regardless of the method. On the other hand, satisfact...
IN-SILICO DESIGN OF ANTIGENIC PEPTIDES AND MOLECULAR CLONING OF CYTOTOXIN ASSOCIATED GENE (cagA) OF H. PYLORI IN AN EXPRESSION VECTOR
Helicobacter pylori (H. pylori) is a spiral, gram-negative pathogen which causes gastric cancer along with MALT lymphoma. It is widespread among the gut microflora and stands first among the pathogens. Cytotoxin-associated gene (cagA) is thought to be the vital protein in the pathogenesis of gastric cancer. Since there are no available vaccines at the moment, and owing to the increasing antibiotic...
INFUSION OF ADRENOMEDULLIN-2 ANTAGONIST INDUCES APOPTOSIS AND CHANGES m-RNA EXPRESSION LEVELS OF ADM2 RECEPTORS IN PLACENTA OF PREGNANT RATS DURING LATE GESTATION AND CAUSES FETOPLACENTAL GROWTH RESTRICTION
Adrenomedullin-2 or Intermedin (ADM2/IMD) is newly identified novel hormone belongs to peptide family like AM, calcitonin, CGRP, amylin and it is widely distributed in various tissues including ovaries, uterus & placenta. The aim of present study was to investigate the role endogenous ADM2 in fetoplacental development in pregnant rats during late gestation period through infusion of ADM2 antag...
GC-MS ANALYSIS OF BIOACTIVE COMPONENTS ON THE FRUIT EXTRACTS OF ARTOCARPUS HIRSUTUS LAM.: A POTENTIAL WILD EDIBLE PLANT
Wild fruits play a significant role in human nutrition, especially as sources of carbohydrates, proteins, vitamins, minerals, dietary fibers, and enormous medicinal potential. Local people in different parts of the country have learned to live on many wild edible fruits available around their localities. Artocarpus hirsutus Lam. is an important wild edible fruit plant belongs to the family Moracea...
The percentage error observed in the claimed standard concentration of cholesterol 200 mg/dl for kits A to D is found to be 0.6, 12.3, 8.96 and 3.76 respectively. As per the guidelines of CLIA 8 allowable error is +10% for cholesterol estimation. Similarly as per the NCEP 9 guidelines + 9 % error is allowable. Therefore, it is noted that kit A is the best kit with an error of just 0.6% followed by...