Most Cited
| Year | 2020 | 2021 | 2022 | Total |
|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 548 | 2053 |
| Citations | 699 | 263 | 21 | 983 |
| Projected Impact Factor | 5.2 | 2.73 | 0.64 |
A COMPREHENSIVE UPDATE ON PYRIMIDINE, COUMARIN AND BENZIMIDAZOLE (PCB)-VERSATILE ANALOGS WITH BIOLOGICAL POTENCY
All three versatile heterocyclic compounds (PCB) are majorly contributing to the field of medicine due to their unique medicinal activities like antimicrobial, anti-inflammatory, anticancer, antioxidant, analgesic, anti-diabetic, anti-viral, anti-ulcer, anti-HIV, and as an anti-protozoal agent (Fig. 1). Many novel PCB analogs are already being used commercially as medicines. Further, the structure...
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BIOSIMILARS: A COMPLETE REVIEW ON MANUFACTURING, FDA APPROVAL, CASE STUDIES
A developing class of medications called biosimilars is created to be used interchangeably with biologics. In living cells, biologics are often large, complicated proteins with a range of potential applications. Biologics are utilised to treat malignancies, endocrine problems, and inflammatory bowel diseases just within the discipline of gastroenterology. Despite the fact that many diseases can be...
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MEROPENEM INDUCED THROMBOCYTOSIS – A RARE ADVERSE DRUG REACTION
Thrombocytosis is defined as platelet count greater than 400, 000/mm3. Thrombocytosis can be either primary or secondary. Meropenem is a parenteral carbapenem antibiotic that has great bactericidal activity against almost all significant aerobes and anaerobes. Common adverse effects such as pain at the injection site, skin rash, transitory metabolic disorders such as increased liver enzyme ...
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ACCIDENTAL INTRATHECAL TRANEXAMIC ACID ADMINISTRATIONS DURING SPINAL ANAESTHESIA AND THEIR REPORTING IN INDIA – A NARRATIVE REVIEW
Look-alike ampoules of tranexamic acid and local anaesthetic heavy bupivacaine are available, leading to accidental administration. We aimed to investigate India-specific incidents of intrathecal tranexamic acid (TXA) administration during spinal anaesthesia to identify manufacturing issues. Our secondary aim was to determine the availability of any national drug error reporting and monitoring sys...
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MITOCHONDRIAL CYTOCHROME C OXIDASE AND SUCCINATE DEHYDROGENASE: EMERGING BIOMARKERS IN CANCER
Mitochondria, renowned as the cell's "powerhouse," plays a pivotal role in cellular metabolism, influencing various physiological and pathological processes, including cancer initiation and progression. This review delves into the significance of mitochondrial enzymes, specifically Succinate Dehydrogenase (SDH) and Cytochrome c Oxidase (CcO), in cancer biology. Alterations in these enzymes' activi...
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ANTIOXIDANT AND ANTITUMOR EFFECTS OF MORINGA OLEIFERA LAM AGAINST EHRLICH’S ASCITES CARCINOMA BEARING MICE
Objectives: Moringa oleifera has enormous attention as the 'natural nutrition of the tropics and an essential food commodity. Antioxidants important in deactivating free radicals having damaging role on biological cells. Polyphenolic compounds are the most prevalent antioxidants seen in plants. Present study aims to evaluate the antioxidant and antitumor effect of ethanolic leaf extract of Moringa...
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FORMULATION AND PROCESS VALIDATION OF MELOXICAM TABLETS
Aim: The aim of present work is to analytical estimation and process validation of conventional tablet dosage form of Meloxicam. Materials and Methods: Tablets were prepared by wet granulation method. Then coating is done as film coating. Results and Discussion: Melting point, pH of drug was measured in triplicate and mean was notedi.e.253°C, 3.9. The maximum absorption was found to be 350 nm by ...
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COMPARING DIFFERENT DOSES OF PENTYLENETETRAZOLE INDUCED EXPERIMENTAL MODEL OF SEIZURE IN MICE
Background: Epilepsy, characterized by repetitive seizures, is studied using pentylenetetrazole (PTZ) in animals. PTZ, a GABA-A inhibitor, is used in various doses in mice to evaluate drug efficacy against seizures. Method: In a PTZ-induced mouse model, different PTZ doses were evaluated: 80 mg/kg i.p., 75 mg/kg i.p., and 80 mg/kg s.c. Seizure behaviors were analyzed, including mortality rates, GT...
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DEVELOPMENT & CHARACTERIZATION OF MOUTH DISSOLVING TABLET OF VOGLIBOSE
The study was aimed at development of voglibose mouth dissolving tablets which can disintegrate or dissolve rapidly once place in the oral cavity. Voglibose is alpha glycosidase inhibitor, drug which is used in a treatment of type 2 diabetes mellitus. The tablets were prepared with different super disintegrant like crospovidone, sodium starch glycolate and lactose at different concentrations. The ...
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SYNTHESIS OF GOLD NANOPARTICLES USING LEAF AQUEOUS EXTRACT OF PHYLLANTHUS VIRGATUS (PHYLLANTHACEAE), ANTIMICROBIAL AND CYTOTOXIC ACTIVITY AGAINST A549 CELL LINE
The local tribes have used Phyllanthus virgatus for Malnutrition, Contagious infections, Inflammations (Gond Tribe), Hepatitis, Cold, Stomach-ache, Gonorrhoea, Fever, Headache, and septic ailments (Chenchus and Yanadis), etc. The gold nanoparticles have a highly specific surface area, and their unique physiochemical characteristics include catalytic activities, optimal properties, antimicrobial ac...
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