Most Cited
| Year | 2020 | 2021 | 2022 | Total |
|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 548 | 2053 |
| Citations | 699 | 263 | 21 | 983 |
| Projected Impact Factor | 3.76 | 2 | 0.64 |
COMPUTATIONAL METHODS IN DRUG DISCOVERY
The efficiency of drug discovery and designing process can be increased by effective strategies given by computational methods. Drug designing is an intense, time consuming and an interdisciplinary venture. Traditionally, drugs were discovered by synthesizing compounds in a long-drawn-out and multi-step process. Recent studies have shown an increase in day by day demand of novel and more efficient...
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ASSESSMENT OF FREE RADICAL SCAVENGING ACTIVITY AND ANTIOXIDANT MEDIATED HEPATOPROTECTIVE EFFECTS OF MALLOTUS ROXBURGHIANUS MUELL. IN DOXORUBICIN INDUCED OXIDATIVE STRESS IN SWISS ALBINO MICE
The aim of this study was to investigate the phytochemical constituents and therapeutic potential of various solvent extracts of Mallotus roxburghianus both in-vitro and in-vivo. Free radicals scavenging activities of various extracts were determined in a cell free system and the hepatoprotective effects was investigated in doxorubicin induced oxidative stress in Swiss Albino mice by estimating va...
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IN-SILICO DEVELOPMENT OF EFFICIENT L-ASPARAGINASE ENZYME FOR ACUTE LYMPHOBLASTIC LEUKAEMIA THERAPY
L-asparaginase has been accepted clinically as an anti-tumour agent for the effective treatment of acute lymphoblastic leukaemia and lymphosarcoma. This enzyme also possesses L-glutaminase activity and causes immunological problems. Hence, efforts have been made to develop mutants with lower or no glutaminase activity. In the present study, a homology model of L-asparaginase obtained from Pectobac...
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CHARACTERIZATION AND BIOLOGICAL EVALUATION OF CRUDE POLYSACCHARIDE FROM VITEX NEGUNDO LINN. LEAVES
Naturally occurring non-starch polysaccharides are known for their therapeutic value. This paper describes isolation, characterization and evaluation of glucose lowering potential of one such plant polysaccharide isolated from the leaves of the plant Vitex negundo. It was isolated and characterized using various analytical techniques and biochemical tests which confirmed the presence of carbohydra...
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A STUDY ON THE IN-VITRO ANTIFUNGAL, LARVICIDAL AND ANTIOXIDANT ACTIVITIES OF ROOT AND SHOOT OF BIOPHYTUM SENSITIVUM (LINN.) DC.
The present study assayed the antifungal, larvicidal and antioxidant properties of the aqueous and acetone extracts of root and shoot of Biophytum sensitivum (Linn.) DC. The aqueous extracts of both root and shoot had little activity against the three test fungi such as A. niger, A. flavus and Penicillium. The acetone shoot extract was also ineffective against these fungi. However, the acetone roo...
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SYNTHESIS AND IN-VITRO ANTIPROLIFERATIVE ACTIVITY OF SUBSTITUTED-2, 3-DIMETHYL-N-(3-(4-PHENYL PIPERAZIN-1-YL) PROPYL)-6, 7-DIHYDRO-5H-BENZO [7] ANNULENE-8-CARBOXYLIC ACIDS
Benzosuberones and phenylpiperazinyl moieties are important heterocyclic compounds which constitute many biological activities which include anti bacterial, anti fungal, anti inflammatory, antioxidant, antitubercular and anti cancer activities. A novel series of 2,3-dimethyl-N-(3-(4-phenyl piperazin-1-yl)propyl)-6,7-dihydro-5H-benzo[7] annulene-8-carboxylic acids (5a-e) have been synthesized in go...
1822
779
SYNTHESIS OF SILVER NANOPARTICLES USING SWERTIPUNICOSIDE AND ITS ACTIVITY ON HUMAN BREAST CANCER CELL LINE (MCF-7)
In the current study, synthesis of silver nanoparticles (AgNPs) using swertipunicoside was tested against human breast cancer cell line (MCF-7). The swertipunicoside was tested against the normal cell line such as vero cells to find out the toxicity of the compound. The synthesized AgNPs were characterized using UV-visible spectroscopy, x - ray powder diffraction (XRD), fourier-transform infrared ...
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FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF BACLOFEN
The objective of the present study is to develop a pharmaceutically stable sustained release matrix tablets of Baclofen and perform the pre-compression, post compression and in-vitro evaluation studies of developed formulation. In this study sustained release matrix tablets of Baclofen were prepared by wet granulation method using mannitol, HPMC K4M, sodium alginate, HPMC K15 in various concentrat...
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DEVELOPMENT AND VALIDATIONOF OF STABILITY INDICATING HPLC METHOD FOR DETERMINATION OF ACOTIAMIDE HYROCHLORIDE
A simple and rapid stability indicating HPLC method for acotiamide hydrochloride was developed and validated. The stationary phase used was thermo gold cyno (250 × 4.6 mm) 5 μ with a mobile phase consisting of mixture of acetonitrile and 10 mM KH2PO4 in water in the ratio of 80:20 v/v at a flow rate of 0.8ml/min. Detection was carried at 284 nm. The retention time observed was 8.1 ± 0.2 min. Th...
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BARRIERS IN UPTAKE OF SCREENING OF CERVICAL CANCER
Background: Cervical cancer is the second most common cancer in women worldwide, with over 90% of cases the occurring in developing countries. India attributes to about 15% of the cancer deaths in the world mostly in rural areas. This dangerous disease can be effectively prevented by creating awareness programs and the possibility of effective management with early screening. Methodology: A prospe...
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