Most Cited
| Year | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total |
|---|---|---|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 549 | 628 | 408 | 376 | 3466 |
| Citations | 2186 | 1048 | 351 | 329 | 66 | 6 | 3986 |
| Projected Impact Factor | 6.64 | 4.43 | 2.15 | 1.07 | 0.58 | 0.38 |
ETHANOLIC SEED EXTRACT OF AFRAMOMUM MELEGUETA PROTECTS AND PRESERVES THE FUNCTIONS AND MICROARCHITECTURE OF THE OVARY OF ADULT FEMALE WISTAR RATS AGAINST PARAQUAT INDUCED TOXICITY
Aframomum melegueta (Alligator pepper) is a tropical plant that belongs to the Zingiberaceae (Ginger) family, consumed for its culinary and health benefits. This study investigated the therapeutic efficacy of ethanolic seed extract of Aframomum melegueta at ameliorating paraquat-induced ovarian toxicity in rat models. Thirty female Wistar rats were divided into control and five test groups (n=5). ...
3409
1752
BIOAVAILABILITY ENHANCEMENT OF ACYCLOVIR USING HIGH-DENSITY GASTRO-RETENTIVE PELLETS
The objective of the present study was to improve the oral bioavailability using high-density gastro-retentive pellets containing solid dispersion of acyclovir. Solid dispersion prepared with polyvinylpyrrolidone (PVP K30) and hydroxypropyl methylcellulose (HPMC) using different ratios 1:1, 1:2, 1:3, 1:4, and 1:5 by solvent evaporation method and characterized for solubility study, dissolution stu...
2390
1333
IN-VITRO ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITY OF SALIX ALBA L. ALONG WITH SIMULTANEOUS HPTLC ANALYSIS OF SALICIN AND FERULIC ACID
Now a day’s interest towards natural and has been growing due to the unhealthy consequences of chemicals in the health industry; though, herbal substances possess several quality control and confirm pharmacological action issues. This present study was designed to determine the effects of Salix alba L. methanolic extract (MESAL) for its antioxidant and anti-inflammatory activity in rat models. F...
2063
1107
SYNTHESIS, CHARACTERIZATION AND IN-VITRO ANTICANCER SCREENING OF VITIS VINIFERA SEED ETHANOLIC EXTRACT LOADED CHITOSAN NANOPARTICLES IN H-29 COLON CANCER CELL LINE
Nanotechnology can be applied to deliver and protect antioxidants in order to control the oxidative stress phenomena in several chronic pathologies. Chitosan (CS) and its carboxymethyl derivatives are smart biopolymers that are non-toxic, biocompatible, and biodegradable, and, hence, suitable for various biomedical applications, such as drug delivery gene therapy and tissue engineering. Vitis vini...
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1037
ISOLATION OF PHYTOCONSTITUENTS AND EVALUATION OF JUSTICIA GENDARUSSA LEAF EXTRACTS FOR ANTI PARKINSONIAN ACTIVITY
The present study investigates the anti-parkinsonian activity of various extracts of Justicia gendarussa (JG) leaves in MPTP-induced neurotoxicity mice. Parkinson’s disease (PD) is a neurodegenerative syndrome belongs to a group of motor symptoms disorders. In PD, brain cells degenerated in some parts of the brain which produce dopamine. JG herb is widely distributed in tropical regions of the w...
1884
1058
STRESS STUDIES OF METFORMIN AND GLICLAZIDE BY HPLC METHOD AND EXTENSION OF METHOD APPLICATION FOR ELUTION OF SOME ANTIVIRAL, ANTI-BACTERIAL AND ANTI-INFLAMMATORY DRUGS
A simple reverse phase SI-HPLC method was developed for the simultaneous estimation of antidiabetic combination of metformin and gliclazide. The method was based on HPLC separation on a reversed-phase C18 column using a mobile phase consisting of phosphate buffer: acetonitrile (40:60, v/v) at a flow rate of 0.8 ml/min. UV determination was achieved at 240 nm. The analytes were subjected to various...
1930
1341
DEVELOPMENT OF VALIDATED HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHY DENSITOMETRIC METHOD FOR QUANTIFICATION OF QUERCETIN IN CAPPARIS DECIDUA EDGEW. STEM
Capparis decidua Edgew. (Capparidaceae) is an important medicinal plant widely used in Ayurveda as anti-inflammatory, anti-arthritic, hepatoprotective, diuretic, digestive, laxative, analgesic and anti-asthmatic. In this study, a sensitive and reliable high-performance thin-layer chromatography (HPTLC) method has been developed for the quantification of a flavonol quercetin as an important marker ...
1738
984
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION STUDIES FOR THE ESTIMATION OF NIMESULIDE AND DICYCLOMINE HYDROCHLORIDE IN FIXED DOSE COMBINATION TABLETS
A simple, accurate, and precise reversed-phase high-pressure liquid chromatography (RP-HPLC) method was developed for the simultaneous estimation of nimesulide and dicyclomine hydro-chloride in fixed-dose combination tablets. The developed method was validated as per ICH guidelines Q2(R1). The chromatographic separation was achieved on Hypersil ODS C18 (200 × 4.6 mm 5 μ) column using methanol: p...
2351
1153
PREPARATION AND IN-VIVO EVALUATION OF SIMVASTATIN CRYSTALLO-CO-AGGLOMERATES
The purpose of this research was to obtain directly compressible agglomerates of simvastatin using a crystallo-co-agglomeration technique and determine its in-vivo performance in rats. Simvastatin Dicalcium phosphate co agglomerates were prepared from Dichloromethane: Isopropyl Myristate: Distilled water system containing polyvinyl pyrrolidone (PVP). Dichloromethane acted as a good solvent for si...
1800
1159
SYNTHESIS CYTOTOXIC AND ANTIMICROBIAL EVALUATION OF SOME NOVEL BENZOXAZOLE ANALOGUES
Benzoxazole and its analogues play an important role as therapeutic agents and exhibit good cytotoxic as well as antimicrobial activity. In the present study, benzoxazole analogues have been prepared by synthetic route; their spectroscopic evaluation was carried out, and then the synthesized compounds were screened for their cytotoxic activity by Allium cepa root model as well as antimicrobial act...
2038
1437