ISOLATION, IDENTIFICATION AND SCREENING FOR BIOACTIVE COMPOUNDS WITH ANTIMICROBIAL ACTIVITIES FROM SUB-AERIAL CYANOBACTERIA OF EASTERN REGION, ODISHA
Background and Objectives: Cyanobacteria are rich in various bioactive compounds. This study aims to screen the antimicrobial activity of sub-aerial Cyanobacteria isolated from sub-aerial habitats (Old monuments and building facades). Materials and Methods: Crude aqueous and organic extracts were screened for phytochemical constituents and tested for their antimicrobial efficacy against human path...
Succinimide and its derivatives are important substitutes of many medicinal compounds in the pharmaceutical field. One of the essential objectives in heterocyclic and medicinal chemistry is the synthesis of molecules having importance as therapeutic agents. Heterocyclic compounds and their derivatives contain an imide ring that can easily cross biological membranes in-vivo. Mannich reactions are o...
ASSESSING PHARMACOTHERAPEUTIC MANAGEMENT OF ANEMIA IN VARIOUS STAGES OF CHRONIC KIDNEY DISEASE AND POST RENAL TRANSPLANT PATIENTS
Introduction: Anemia in CKD occurs when the kidneys are damaged or diseased. They cannot make enough EPO, which stimulates the bone marrow to produce RBC. It is associated with increased cardiovascular diseases, hospitalization, reduced quality of life, cognitive impairment, and mortality. Materials and Methods: A prospective observational study was conducted on CKD patients. Demographic details, ...
ANTIALZHEIMER ACTIVITY OF METHANOLIC EXTRACT OF BUCHNANIA LANZAN LEAVES BY USING BEHAVIOUR MODELS ON ALBINO WISTAR RAT
Objective: The key objective of the study is to evaluate the Anti-Alzheimer activity of methanolic extracts of buchnania Lanzan leaves by Aluminum Chloride induced Alzheimer's. Buchanania lanzan Spreng a well-known forest plant of the family Anacardiaceae. It is reported to have numerous uses in the indigenous system of medicine in India. Material and Methods: Albino Wistar rats were administered ...
HPTLC SCREENING OF AMINO ACID PROFILE OF CURCUMA SPECIES FROM MELGHAT FORESTS DIST. AMRAVATI MAHARASHTRA
Genus Curcuma L. ( Zingiberaceae), comprising of 120 species, is distributed throughout South and South-East Asia, with few species extending to China, Australia, and South Pacific. Four species of Curcuma are reported from Melghat. Of these C. longa L. is cultivated while C. inodora Blatt., C. pseudomontana J. Graham and C. decipiens are wild. C. decipiens being rare could not be collected. C...
EVALUATION OF ANTI-INFLAMMATORY AND ANTI-DIABETIC EFFECTS OF DIFFERENT FRACTIONS OF HOLARRHENA PUBESCENS (BUCH.- HAM.) WALL. SEED EXTRACT
Inflammation is a chemical-mediated defense mechanism of body. Inflammatory process is also associated with development of various diseases like rheumatoid arthritis, psoriasis, atherosclerosis, and diabetes. Diabetes mellitus is a most common and life-threatening health problem in today’s date. Several marketed anti-diabetic drugs are characterized with side effects. Hence there is a need to se...
Common chicory (Cichorium intybus L.) plant belonging to sunflower family primarily grown for its root which is used as a coffee substitute but is also widely used in folk medicine to treat various ailments ranging from wounds to diabetes. The plant is a good tonic cooling agent and is useful in headache, throat inflammation, immune stimulation, mutagenic, probiotic, hepatoprotective, antibact...
SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDY OF RARE EARTH COMPLEXES OF SCHIFF BASE DERIVED FROM 4-AMINO-3-HYDROXY BENZOIC ACID
Schiff base was prepared by using 4-amino-3-hydroxy benzoic acid and 4-nitrobenzaldehyde, namely (E)-3-hydroxy-4-((4-nitrobenzylidene) amino)benzoic acid. In the preparation of rare earth complexes, nitrates of lanthanum, Cerium, and Praseodymium were used with Schiff base. Rare earth Schiff base complexes were prepared by using NaOH to maintain the pH of solvent. Synthesized Schiff base ligand an...
A STUDY OF ANALYTICAL METHOD DEVELOPMENT, VALIDATION AND FORCED DEGRADATION FOR SIMULTANEOUS ESTIMATION OF GLYCOPYRROLATE AND FORMOTEROL FUMARATE IN BULK DRUG BY UHPLC METHOD
The present study was proposed to develop a simple, rapid, and economical UHPLC method was described for the method development, validation and forced degradation for the simultaneous estimation of glycopyrrolate and formoterol fumarate in bulk drug. The chromatographic conditions were observed in the column using Zorbax RXC18 (150 × 4.6 mm) 5 µm using a mobile phase composition of Water: Aceton...
TO INVESTIGATE THE EFFECT OF SPAN 60 AND SPAN 80 POLYMER ON RELEASE RATE OF SIMVASTATIN NOISOME IN COMPARISON WITH PURE SIMVASTATIN
The main objective of the present study was to develop and evaluate the simvastatin noisome using different grades of nonionic surfactants. It was hypothesized that niosomes would increase in vitro release of simvastatin in comparison to the API Mumbai. Niosome were prepared by thin-film hydration method and evaluated for particle size, entrapment efficiency, PDI, and in vitro release. The differe...