Posted by admin on Jul 2, 2014 in |
A simple, accurate, rapid and sensitive high performance thin layer chromatographic method has been developed for the estimation of Tapentadol Hydrochloride in bulk and its tablet dosage form. Chromatographic separation of the drugs was performed on aluminum plates precoated with silica gel 60 F254 as the stationary phase and the solvent system consisted of methanol: toluene (4:1v/v). Densitometric evaluation of the separated zones was performed by UV detector at 272 nm. The drug was satisfactorily resolved with Rf value 0.5 ± 0.02.The method was linear over concentration range of 1500-2000 (1.5-2.0 µL) ng/spot. The analytical percent recovery was found to be 99.92%.The intra and interday precision with percent relative standard deviation (%RSD) values in the range of 0.0895 to 0.0892. The validation of the method was carried as per ICH guidelines. The proposed HPTLC method was successfully employed for routine analysis of bulk drug and its commercial tablet dosage...
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Posted by admin on Jul 2, 2014 in |
Eudragit RS100 microcapsules containing Aspirin as a model drug was prepared using solvent evaporation technique. The drug was dispersed in the organic phase and poured into the aqueous phase with stirring until microcapsules formation. The product was collected by filtration and air dried. The particle size analysis of the products was done and normal distribution curve showed for the same size range of different theoretical drug content, microcapsules had different size distribution. The sphericity of the microcapsule was greatly affected by the theoretical drug loaded. The mean microcapsule size decreased upon increasing the percent of theoretical drug content and then increased again. The surface of spherical microcapsule was smooth and no drug crystals attached to the surface. It was noticed drug crystals in the microcapsule structure. The mean actual drug content was markedly higher than the theoretical one. In the same product prepared with the same theoretical drug content, there was a relationship between the actual drug content and the product particle size. These findings were explained according to...
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Posted by admin on Jul 2, 2014 in |
Three simple, rapid, sensitive, specific and economic spectrophotometric methods were developed and validated for simultaneous quantitation of timolol maleate (TM) and brimonidine tartarate (BT) in bulk powder and eye drops. Vierordt’s and bivariate calibration algorithm spectrophotometric methods were developed for the simultaneous estimation of cited drugs in a binary mixture without previous separation. In the simultaneous equation method (Vierordt’s), TM and BT were quantified using their absorptivity values at selected wavelengths 257 nm and 295 nm, respectively. Also bivariate calibration procedure was successfully applied for simultaneous determination of both drugs. Difference spectrophotometric method was also tried and showed high selectivity for BT determination without any interference from TM or eye drops additives. The accuracy and reproducibility of the proposed methods were statistically validated by recovery studies. The calibration curves were found to be rectilinear over the concentration ranges 5-85 μg/mL for TM in all methods. BT calibration curves were rectilinear over the concentration (2–35 μg/mL) in case of D1 and Vierordt’s methods, while (5–35 μg/mL) in case of bivariate...
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Posted by admin on Jul 2, 2014 in |
Eudragit RS100 microcapsules containing Aspirin as a model drug was prepared using solvent evaporation technique. The drug was dispersed in the organic phase and poured into the aqueous phase with stirring until microcapsules formation. The product was collected by filtration and air dried. The particle size analysis of the products was done and normal distribution curve showed for the same size range of different theoretical drug content, microcapsules had different size distribution. The sphericity of the microcapsule was greatly affected by the theoretical drug loaded. The mean microcapsule size decreased upon increasing the percent of theoretical drug content and then increased again. The surface of spherical microcapsule was smooth and no drug crystals attached to the surface. It was noticed drug crystals in the microcapsule structure. The mean actual drug content was markedly higher than the theoretical one. In the same product prepared with the same theoretical drug content, there was a relationship between the actual drug content and the product particle size. These findings were explained according to...
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Posted by admin on Jul 2, 2014 in |
The aim of the present study was to improve commercial twice-a-day Acebrophylline formulation to once-a-day new formulation to improve patient compliances. The double-layered tablet was composed of the fast release layer (Acebrophylline 50 mg) and sustained release layer (Acebrophylline 150 mg). To develop the double-layered tablet, the fast release and sustained release layers were prepared using polymer, wax, excipients and malic acid. The inclusion of malic acid in sustained release layer in double-layered tablet was showed to decrease release rates in pH 1.2 equal to dissolution rate of pH 6.8. The pharmacokinetic parameters such as AUCt and Cmax of double-layered tablet having fast release and sustained release layer were tested on mini pigs. These results showed similar pharmacokinetic parameters of AUCt and Cmax between Surfolase capsule and double-layered tablet. The 90% confidence intervals of the AUCt ratio and the Cmax ratio for double-layered tablet and Surfolase capsule were log 0.9402 ~ log 1.0245 and log 0.9983 ~ log 1.1542, respectively. This mean show that double-layered tablet using malic acid,...
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