Posted by admin on May 1, 2014 in |
The objective of the present work was to development and validation of stability indicating RP-HPLC assay by applying different stress degradation conditions on lornoxicam in Self Emulsifying Drug Delivery System (SEDDS) formulation. HPLC separation was achieved on analytical technique using C-18 column and mobile phase of Acetonitrile: Methanol (65:35, v/v) at a UV detector. The lornoxicam drug consist in SEDDS formulation was subjected to acid, alkali, oxidation, dry heat and photo degradation treatment apply as stress degradation condition. The method was linear in the drug concentration range of 10-60 μg/ml with a correlation coefficient 0.999. The stress degradation studies showed that Lornoxicam contains in Self Emulsifying Drug Delivery System (SEDDS) formulation undergoes degradation in acid, alkali, oxidation and dry heat condition respectively within the limit as per ICH guidelines and stable in photo-degradation...
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Posted by admin on May 1, 2014 in |
The study aimed to assess the efficacy and safety of Amoxicillin/Clavulanate 625 mg and Amoxicillin/Clavulanate 1 gram in chronic bronchitis patients. Chronic bronchitis, a type of COPD defined by a productive cough that lasts for 3 months or more for at least 2 years, other symptoms include wheezing and breathlessness, upon exertion. It is caused by recurring irritation to the epithelium of bronchi, resulting in chronic inflammation, edema and increased production of mucus by goblet. Clavulanate has high affinity for and binds to certain β-lactamases that generally inactivate amoxicillin by hydrolyzing its β-lactam ring. Combining Clavulanate potassium with amoxicillin extends the antibacterial spectrum of Amoxicillin. The objective is to evaluate the efficacy of monotherapy, adverse drug reaction and perform the comparison of both in Amoxicillin/Clavulanate 625 mg and Amoxicillin/Clavulanate 1 gram. A prospective observational study design was used and the Clinical symptoms, X-ray, PFT (FVC, FEV1, FEF, (FEV1/FVC) and Bacteriologic assessment were assessed to monitor its efficacy and safety. Hence the study concluded that Amoxicillin/Clavulanate 625 mg group was...
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Posted by admin on May 1, 2014 in |
A series of novel L-arginine analogues were synthesized and screened for in-vitro anti-oxidant activity by Nitric oxide (NO) scavenging and 1-1-diphenyl-2-picrylhydrazyl (DPPH) scavenging methods. The purity of the synthesized compounds has been characterized by various analytical techniques such as UV, FTIR and TLC. The synthesized compounds were evaluated for in-vitro anti-oxidant activity by NO scavenging and DPPH scavenging methods. The study concluded that the compounds4, 5, 6, 7, 8, 10, 11 exhibited very significant anti-oxidant action in NO scavenging method and compounds 4, 6, 7, 8, 10, 11 has exhibited significant anti-oxidant activity in DPPH scavenging method when compared with that of the standard Ascorbic...
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Posted by admin on May 1, 2014 in |
The present research work was conducted to formulate and evaluate Anthralin microemulsion gel using Karanj oil with an objective of improving solubility of the Anthralin. The pseudo ternary phase diagrams were developed for combinations of Karanj oil as the oil phase, Span-20 as surfactant and as Capryol 90 as cosurfactant using water titration method. Microemulsions obtained were analyzed for topical permeability of anthralin using Franz diffusion cell through an excised rat skin. Higher in-vitro permeation was observed from Karanj oil based microemulsion (ME1) having ratio of 1:1. Thus it was selected for further formulation studies. The developed microemulsion was characterized for globule size, polydispersibility index and results were found be 50 nm and 0.341 respectively. Centrifugation studies were carried out to confirm the stability of the developed formulation. The formulation was thickened with a gelling agent carbopol 940, to yield a gel with desirable properties facilitating the topical application. The developed microemulsion gel was characterized for pH, spreadability, refractive index and viscosity. Optimized formulation was then subjected to in-vitro...
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Posted by admin on May 1, 2014 in |
A series of novel L-arginine analogues were synthesized characterized and screened for analgesic activity by acetic acid induced analgesia model. The purity of the synthesized compounds has been characterized by various analytical techniques such as UV, FTIR and TLC. The synthesized compounds were evaluated for analgesic activity by acetic acid induced analgesia in mice using paracetamol as the standard drug for comparing the test results. The study concluded that the compound 1, 2, 3 and 4 were found to exhibit significant anti-pyretic...
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